Association of Atherogenic Index of Plasma with Cardiometabolic Risk Factors and Markers in Lean 14-to-20-Year-Old Individuals: A Cross-Sectional Study
Cardiometabolic risk factors at a young age pose a significant risk for developing atherosclerotic cardiovascular disease in adulthood. Atherogenic dyslipidemia is highly associated with obesity and metabolic syndrome already in young age. It remains unclear whether cardiometabolic risk factors asso...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Online Access: | https://www.mdpi.com/2227-9067/10/7/1144 |
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| author | Katarína Šebeková Radana Gurecká Melinda Csongová Ivana Koborová Peter Celec |
| author_facet | Katarína Šebeková Radana Gurecká Melinda Csongová Ivana Koborová Peter Celec |
| author_sort | Katarína Šebeková |
| collection | DOAJ |
| description | Cardiometabolic risk factors at a young age pose a significant risk for developing atherosclerotic cardiovascular disease in adulthood. Atherogenic dyslipidemia is highly associated with obesity and metabolic syndrome already in young age. It remains unclear whether cardiometabolic risk factors associate with the atherogenic index of plasma (AIP = log (TAG/HDL-C) in lean subjects with low atherogenic risk. As both the AIP and markers of cardiometabolic risk are continuous variables, we expected their association to be linear before the manifestation of obesity and atherogenic dyslipidemia. We analyzed the prevalence of increased atherogenic risk (AIP ≥ 0.11) in 2012 lean 14-to-20-year-old subjects (55% females) and the trends of cardiometabolic risk factors across the quartiles (Q) of AIP in a subgroup of 1947 (56% females) subjects with low atherogenic risk (AIP < 0.11). The prevalence of AIP ≥ 0.11 reached 3.6% in females and 8.5% in males. HDL-C, non-HDL-C, triglycerides, and the continuous metabolic syndrome score showed a stepwise worsening across the AIP quartiles in both sexes. Measures of obesity and insulin resistance were worse in Q4 vs. Q1 groups, and leukocyte counts were higher in Q4 and Q3 vs. Q1. Females in Q4 presented with a higher C-reactive protein and lower adiponectin, estradiol, and testosterone levels. The multivariate regression model selected non-HDL-C, QUICKI, and erythrocyte counts as significant predictors of AIP in males; and non-HDL-C and C-reactive protein in females. A question arises whether the lean individuals on the upper edge of low atherogenic risk are prone to earlier manifestation of metabolic syndrome and shift to the higher AIP risk group. |
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| language | English |
| last_indexed | 2024-03-11T01:11:59Z |
| publishDate | 2023-06-01 |
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| record_format | Article |
| series | Children |
| spelling | doaj.art-bc8ceb09cc9f4a3685069cac5c13ca162023-11-18T18:48:48ZengMDPI AGChildren2227-90672023-06-01107114410.3390/children10071144Association of Atherogenic Index of Plasma with Cardiometabolic Risk Factors and Markers in Lean 14-to-20-Year-Old Individuals: A Cross-Sectional StudyKatarína Šebeková0Radana Gurecká1Melinda Csongová2Ivana Koborová3Peter Celec4Institute of Molecular BioMedicine, Faculty of Medicine, Comenius University, 81108 Bratislava, SlovakiaInstitute of Molecular BioMedicine, Faculty of Medicine, Comenius University, 81108 Bratislava, SlovakiaInstitute of Molecular BioMedicine, Faculty of Medicine, Comenius University, 81108 Bratislava, SlovakiaInstitute of Molecular BioMedicine, Faculty of Medicine, Comenius University, 81108 Bratislava, SlovakiaInstitute of Molecular BioMedicine, Faculty of Medicine, Comenius University, 81108 Bratislava, SlovakiaCardiometabolic risk factors at a young age pose a significant risk for developing atherosclerotic cardiovascular disease in adulthood. Atherogenic dyslipidemia is highly associated with obesity and metabolic syndrome already in young age. It remains unclear whether cardiometabolic risk factors associate with the atherogenic index of plasma (AIP = log (TAG/HDL-C) in lean subjects with low atherogenic risk. As both the AIP and markers of cardiometabolic risk are continuous variables, we expected their association to be linear before the manifestation of obesity and atherogenic dyslipidemia. We analyzed the prevalence of increased atherogenic risk (AIP ≥ 0.11) in 2012 lean 14-to-20-year-old subjects (55% females) and the trends of cardiometabolic risk factors across the quartiles (Q) of AIP in a subgroup of 1947 (56% females) subjects with low atherogenic risk (AIP < 0.11). The prevalence of AIP ≥ 0.11 reached 3.6% in females and 8.5% in males. HDL-C, non-HDL-C, triglycerides, and the continuous metabolic syndrome score showed a stepwise worsening across the AIP quartiles in both sexes. Measures of obesity and insulin resistance were worse in Q4 vs. Q1 groups, and leukocyte counts were higher in Q4 and Q3 vs. Q1. Females in Q4 presented with a higher C-reactive protein and lower adiponectin, estradiol, and testosterone levels. The multivariate regression model selected non-HDL-C, QUICKI, and erythrocyte counts as significant predictors of AIP in males; and non-HDL-C and C-reactive protein in females. A question arises whether the lean individuals on the upper edge of low atherogenic risk are prone to earlier manifestation of metabolic syndrome and shift to the higher AIP risk group.https://www.mdpi.com/2227-9067/10/7/1144atherogenic index of plasmaleanyoung adultscardiometabolic risk factorscontinuous metabolic syndrome scoreblood count |
| spellingShingle | Katarína Šebeková Radana Gurecká Melinda Csongová Ivana Koborová Peter Celec Association of Atherogenic Index of Plasma with Cardiometabolic Risk Factors and Markers in Lean 14-to-20-Year-Old Individuals: A Cross-Sectional Study Children atherogenic index of plasma lean young adults cardiometabolic risk factors continuous metabolic syndrome score blood count |
| title | Association of Atherogenic Index of Plasma with Cardiometabolic Risk Factors and Markers in Lean 14-to-20-Year-Old Individuals: A Cross-Sectional Study |
| title_full | Association of Atherogenic Index of Plasma with Cardiometabolic Risk Factors and Markers in Lean 14-to-20-Year-Old Individuals: A Cross-Sectional Study |
| title_fullStr | Association of Atherogenic Index of Plasma with Cardiometabolic Risk Factors and Markers in Lean 14-to-20-Year-Old Individuals: A Cross-Sectional Study |
| title_full_unstemmed | Association of Atherogenic Index of Plasma with Cardiometabolic Risk Factors and Markers in Lean 14-to-20-Year-Old Individuals: A Cross-Sectional Study |
| title_short | Association of Atherogenic Index of Plasma with Cardiometabolic Risk Factors and Markers in Lean 14-to-20-Year-Old Individuals: A Cross-Sectional Study |
| title_sort | association of atherogenic index of plasma with cardiometabolic risk factors and markers in lean 14 to 20 year old individuals a cross sectional study |
| topic | atherogenic index of plasma lean young adults cardiometabolic risk factors continuous metabolic syndrome score blood count |
| url | https://www.mdpi.com/2227-9067/10/7/1144 |
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