Information Theoretical Study of Cross-Talk Mediated Signal Transduction in MAPK Pathways
Biochemical networks having similar functional pathways are often correlated due to cross-talk among the homologous proteins in the different networks. Using a stochastic framework, we address the functional significance of the cross-talk between two pathways. A theoretical analysis on generic MAPK...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-09-01
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| Series: | Entropy |
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| Online Access: | https://www.mdpi.com/1099-4300/19/9/469 |
| _version_ | 1798002517400879104 |
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| author | Alok Kumar Maity Pinaki Chaudhury Suman K. Banik |
| author_facet | Alok Kumar Maity Pinaki Chaudhury Suman K. Banik |
| author_sort | Alok Kumar Maity |
| collection | DOAJ |
| description | Biochemical networks having similar functional pathways are often correlated due to cross-talk among the homologous proteins in the different networks. Using a stochastic framework, we address the functional significance of the cross-talk between two pathways. A theoretical analysis on generic MAPK pathways reveals cross-talk is responsible for developing coordinated fluctuations between the pathways. The extent of correlation evaluated in terms of the information theoretic measure provides directionality to net information propagation. Stochastic time series suggest that the cross-talk generates synchronisation in a cell. In addition, the cross-interaction develops correlation between two different phosphorylated kinases expressed in each of the cells in a population of genetically identical cells. Depending on the number of inputs and outputs, we identify signal integration and signal bifurcation motif that arise due to inter-pathway connectivity in the composite network. Analysis using partial information decomposition, an extended formalism of multivariate information calculation, also quantifies the net synergy in the information propagation through the branched pathways. Under this formalism, signature of synergy or redundancy is observed due to the architectural difference in the branched pathways. |
| first_indexed | 2024-04-11T11:53:21Z |
| format | Article |
| id | doaj.art-bc8e7d49243a4f2aa40e6c6958e5f6af |
| institution | Directory Open Access Journal |
| issn | 1099-4300 |
| language | English |
| last_indexed | 2024-04-11T11:53:21Z |
| publishDate | 2017-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Entropy |
| spelling | doaj.art-bc8e7d49243a4f2aa40e6c6958e5f6af2022-12-22T04:25:15ZengMDPI AGEntropy1099-43002017-09-0119946910.3390/e19090469e19090469Information Theoretical Study of Cross-Talk Mediated Signal Transduction in MAPK PathwaysAlok Kumar Maity0Pinaki Chaudhury1Suman K. Banik2Department of Chemistry, University of Calcutta, 92 Acharya Prafulla Chandra Road, Kolkata 700009, IndiaDepartment of Chemistry, University of Calcutta, 92 Acharya Prafulla Chandra Road, Kolkata 700009, IndiaDepartment of Chemistry, Bose Institute, 93/1 Acharya Prafulla Chandra Road, Kolkata 700009, IndiaBiochemical networks having similar functional pathways are often correlated due to cross-talk among the homologous proteins in the different networks. Using a stochastic framework, we address the functional significance of the cross-talk between two pathways. A theoretical analysis on generic MAPK pathways reveals cross-talk is responsible for developing coordinated fluctuations between the pathways. The extent of correlation evaluated in terms of the information theoretic measure provides directionality to net information propagation. Stochastic time series suggest that the cross-talk generates synchronisation in a cell. In addition, the cross-interaction develops correlation between two different phosphorylated kinases expressed in each of the cells in a population of genetically identical cells. Depending on the number of inputs and outputs, we identify signal integration and signal bifurcation motif that arise due to inter-pathway connectivity in the composite network. Analysis using partial information decomposition, an extended formalism of multivariate information calculation, also quantifies the net synergy in the information propagation through the branched pathways. Under this formalism, signature of synergy or redundancy is observed due to the architectural difference in the branched pathways.https://www.mdpi.com/1099-4300/19/9/469Mutual informationpartial information decompositionnet synergyLangevin equation |
| spellingShingle | Alok Kumar Maity Pinaki Chaudhury Suman K. Banik Information Theoretical Study of Cross-Talk Mediated Signal Transduction in MAPK Pathways Entropy Mutual information partial information decomposition net synergy Langevin equation |
| title | Information Theoretical Study of Cross-Talk Mediated Signal Transduction in MAPK Pathways |
| title_full | Information Theoretical Study of Cross-Talk Mediated Signal Transduction in MAPK Pathways |
| title_fullStr | Information Theoretical Study of Cross-Talk Mediated Signal Transduction in MAPK Pathways |
| title_full_unstemmed | Information Theoretical Study of Cross-Talk Mediated Signal Transduction in MAPK Pathways |
| title_short | Information Theoretical Study of Cross-Talk Mediated Signal Transduction in MAPK Pathways |
| title_sort | information theoretical study of cross talk mediated signal transduction in mapk pathways |
| topic | Mutual information partial information decomposition net synergy Langevin equation |
| url | https://www.mdpi.com/1099-4300/19/9/469 |
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