Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling

Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling

Sanguinarine (SNG), a benzophenanthridine alkaloid, has displayed various anticancer abilities in several vivo and in vitro studies. However, the anticancer potential of SNG is yet to be established in multiple myeloma (MM), a mostly incurable malignancy of plasma cells. In this study, we aimed to i...

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Bibliographic Details
Main Authors: Sabah Akhtar, Iman W. Achkar, Kodappully S. Siveen, Shilpa Kuttikrishnan, Kirti S. Prabhu, Abdul Q. Khan, Eiman I. Ahmed, Fairooz Sahir, Jayakumar Jerobin, Afsheen Raza, Maysaloun Merhi, Hesham M. Elsabah, Ruba Taha, Halima El Omri, Hatem Zayed, Said Dermime, Martin Steinhoff, Shahab Uddin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Oncology
Subjects:
apoptosis
caspases
STAT3
sanguinarine
multiple myeloma
hematological malignancy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00285/full

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