Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology
Crotalus durissus ruruima is a rattlesnake subspecies mainly found in Roraima, the northernmost state of Brazil. Envenomings caused by this subspecies lead to severe clinical manifestations (e.g. respiratory muscle paralysis, rhabdomyolysis, and acute renal failure) that can lead to the victim’s dea...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.659515/full |
| _version_ | 1818608130991325184 |
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| author | Manuela B. Pucca Paulo Sérgio Bernarde Anderson Maciel Rocha Patrik F. Viana Raimundo Erasmo Souza Farias Felipe A. Cerni Felipe A. Cerni Isadora S. Oliveira Isabela G. Ferreira Eliseu A. Sandri Jacqueline Sachett Jacqueline Sachett Fan Hui Wen Vanderson Sampaio Andreas H. Laustsen Marco A. Sartim Marco A. Sartim Wuelton M. Monteiro Wuelton M. Monteiro |
| author_facet | Manuela B. Pucca Paulo Sérgio Bernarde Anderson Maciel Rocha Patrik F. Viana Raimundo Erasmo Souza Farias Felipe A. Cerni Felipe A. Cerni Isadora S. Oliveira Isabela G. Ferreira Eliseu A. Sandri Jacqueline Sachett Jacqueline Sachett Fan Hui Wen Vanderson Sampaio Andreas H. Laustsen Marco A. Sartim Marco A. Sartim Wuelton M. Monteiro Wuelton M. Monteiro |
| author_sort | Manuela B. Pucca |
| collection | DOAJ |
| description | Crotalus durissus ruruima is a rattlesnake subspecies mainly found in Roraima, the northernmost state of Brazil. Envenomings caused by this subspecies lead to severe clinical manifestations (e.g. respiratory muscle paralysis, rhabdomyolysis, and acute renal failure) that can lead to the victim’s death. In this review, we comprehensively describe C. d. ruruima biology and the challenges this subspecies poses for human health, including morphology, distribution, epidemiology, venom cocktail, clinical envenoming, and the current and future specific treatment of envenomings by this snake. Moreover, this review presents maps of the distribution of the snake subspecies and evidence that this species is responsible for some of the most severe envenomings in the country and causes the highest lethality rates. Finally, we also discuss the efficacy of the Brazilian horse-derived antivenoms to treat C. d. ruruima envenomings in Roraima state. |
| first_indexed | 2024-12-16T14:37:46Z |
| format | Article |
| id | doaj.art-bc90a44de9ed43e1b905440349f20186 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-16T14:37:46Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-bc90a44de9ed43e1b905440349f201862022-12-21T22:28:03ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-06-011210.3389/fimmu.2021.659515659515Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical ToxinologyManuela B. Pucca0Paulo Sérgio Bernarde1Anderson Maciel Rocha2Patrik F. Viana3Raimundo Erasmo Souza Farias4Felipe A. Cerni5Felipe A. Cerni6Isadora S. Oliveira7Isabela G. Ferreira8Eliseu A. Sandri9Jacqueline Sachett10Jacqueline Sachett11Fan Hui Wen12Vanderson Sampaio13Andreas H. Laustsen14Marco A. Sartim15Marco A. Sartim16Wuelton M. Monteiro17Wuelton M. Monteiro18Medical School, Federal University of Roraima, Boa Vista, BrazilLaboratório de Herpetologia, Centro Multidisciplinar, Universidade Federal do Acre, Cruzeiro do Sul, BrazilBiology Department, Cathedral Faculty of Higher Education, Boa Vista, BrazilNational Institute of Amazonian Research, Biodiversity Coordination, Laboratory of Animal Genetics, Manaus, BrazilNational Institute of Amazonian Research, Biodiversity Coordination, Laboratory of Animal Genetics, Manaus, BrazilMedical School, Federal University of Roraima, Boa Vista, BrazilDepartment of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, BrazilDepartment of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, BrazilDepartment of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, BrazilInsikiram Institute of Indigenous Higher Studies, Federal University of Roraima, Boa Vista, BrazilDepartment of Medicine and Nursing, School of Health Sciences, Amazonas State University, Manaus, BrazilDepartment of Teaching and Research, Alfredo da Matta Foundation, Manaus, BrazilAntivenom Production Section, Butantan Institute, São Paulo, Brazil0Department of Teaching and Research, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus, Brazil1Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark0Department of Teaching and Research, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus, Brazil2Institute of Biological Sciences, Amazonas Federal University, Manaus, BrazilDepartment of Medicine and Nursing, School of Health Sciences, Amazonas State University, Manaus, Brazil0Department of Teaching and Research, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus, BrazilCrotalus durissus ruruima is a rattlesnake subspecies mainly found in Roraima, the northernmost state of Brazil. Envenomings caused by this subspecies lead to severe clinical manifestations (e.g. respiratory muscle paralysis, rhabdomyolysis, and acute renal failure) that can lead to the victim’s death. In this review, we comprehensively describe C. d. ruruima biology and the challenges this subspecies poses for human health, including morphology, distribution, epidemiology, venom cocktail, clinical envenoming, and the current and future specific treatment of envenomings by this snake. Moreover, this review presents maps of the distribution of the snake subspecies and evidence that this species is responsible for some of the most severe envenomings in the country and causes the highest lethality rates. Finally, we also discuss the efficacy of the Brazilian horse-derived antivenoms to treat C. d. ruruima envenomings in Roraima state.https://www.frontiersin.org/articles/10.3389/fimmu.2021.659515/fullCrotalus durissusCrotalus durissus ruruimarattlesnakesnakebiteenvenomingvenom |
| spellingShingle | Manuela B. Pucca Paulo Sérgio Bernarde Anderson Maciel Rocha Patrik F. Viana Raimundo Erasmo Souza Farias Felipe A. Cerni Felipe A. Cerni Isadora S. Oliveira Isabela G. Ferreira Eliseu A. Sandri Jacqueline Sachett Jacqueline Sachett Fan Hui Wen Vanderson Sampaio Andreas H. Laustsen Marco A. Sartim Marco A. Sartim Wuelton M. Monteiro Wuelton M. Monteiro Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology Frontiers in Immunology Crotalus durissus Crotalus durissus ruruima rattlesnake snakebite envenoming venom |
| title | Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology |
| title_full | Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology |
| title_fullStr | Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology |
| title_full_unstemmed | Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology |
| title_short | Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology |
| title_sort | crotalus durissus ruruima current knowledge on natural history medical importance and clinical toxinology |
| topic | Crotalus durissus Crotalus durissus ruruima rattlesnake snakebite envenoming venom |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.659515/full |
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