ASSOCIATION OF INTERLEUKIN-10 -592A>C AND -819T>C POLYMORPHISMS WITH GASTRIC CANCER RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS OF 44 CASE-CONTROL STUDIES
ABSTRACT Introduction: A series of studies have evaluated the association between -592A>C and -819T>C polymorphisms in the promoter regions of Interleukin-10 (IL-10) and gastric cancer (GC) risk. However, the results remain inconclusive. Objective: To better understand the association of the...
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| Format: | Article |
| Language: | English |
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Colégio Brasileiro de Cirurgia Digestiva
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| Series: | ABCD: Arquivos Brasileiros de Cirurgia Digestiva |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202019000100500&tlng=en |
| _version_ | 1819180304548495360 |
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| author | Mansour MOGHMI Amir ARJMANDI Kazem AGHILI Mohammadali JAFARI Masoud ZARE-SHEHNEH Shohreh RASTEGAR Seyed Mojtaba ABOLBAGHAEI Hossein NEAMATZADEH |
| author_facet | Mansour MOGHMI Amir ARJMANDI Kazem AGHILI Mohammadali JAFARI Masoud ZARE-SHEHNEH Shohreh RASTEGAR Seyed Mojtaba ABOLBAGHAEI Hossein NEAMATZADEH |
| author_sort | Mansour MOGHMI |
| collection | DOAJ |
| description | ABSTRACT Introduction: A series of studies have evaluated the association between -592A>C and -819T>C polymorphisms in the promoter regions of Interleukin-10 (IL-10) and gastric cancer (GC) risk. However, the results remain inconclusive. Objective: To better understand the association of the polymorphisms with GC risk, we performed a comprehensive meta-analysis. Method: An electronic search was performed of several databases to identify relevant studies up to April 2018. Results: A total of 44 case-control studies, including 26 studies on IL-10 -592A>C (5,332 cases and 8,272 controls) and 18 studies on IL-10 -819T>C (3,431 cases and 6,109 controls) were selected. Overall, -592A>C polymorphism was associated with the risk of GC under the heterozygote model (OR=1.153, 95% CI=1.020-1.305, p=0.023), but not -819T>C polymorphism. When stratified by ethnicity, significant association was only observed in the Asians under the allele model (OR=1.153, 95% CI=1.007-1.320, p=0.040) and the heterozygote model (OR=1.218, 95% CI=1.076-1.379, p=0.002) for -592A>C. Conclusion: The current meta-analysis results inconsistent with previous meta-analyses; showed that the IL-10 -592A>C polymorphism, but not -819T>C polymorphism, may be contributed to the susceptibility of GC in overall and Asian populations. |
| first_indexed | 2024-12-22T22:12:13Z |
| format | Article |
| id | doaj.art-bc90d75813514289ace981d38a2f4e33 |
| institution | Directory Open Access Journal |
| issn | 0102-6720 |
| language | English |
| last_indexed | 2024-12-22T22:12:13Z |
| publisher | Colégio Brasileiro de Cirurgia Digestiva |
| record_format | Article |
| series | ABCD: Arquivos Brasileiros de Cirurgia Digestiva |
| spelling | doaj.art-bc90d75813514289ace981d38a2f4e332022-12-21T18:10:51ZengColégio Brasileiro de Cirurgia DigestivaABCD: Arquivos Brasileiros de Cirurgia Digestiva0102-672010.1590/0102-672020180001e1415ASSOCIATION OF INTERLEUKIN-10 -592A>C AND -819T>C POLYMORPHISMS WITH GASTRIC CANCER RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS OF 44 CASE-CONTROL STUDIESMansour MOGHMIAmir ARJMANDIKazem AGHILIMohammadali JAFARIMasoud ZARE-SHEHNEHShohreh RASTEGARSeyed Mojtaba ABOLBAGHAEIHossein NEAMATZADEHABSTRACT Introduction: A series of studies have evaluated the association between -592A>C and -819T>C polymorphisms in the promoter regions of Interleukin-10 (IL-10) and gastric cancer (GC) risk. However, the results remain inconclusive. Objective: To better understand the association of the polymorphisms with GC risk, we performed a comprehensive meta-analysis. Method: An electronic search was performed of several databases to identify relevant studies up to April 2018. Results: A total of 44 case-control studies, including 26 studies on IL-10 -592A>C (5,332 cases and 8,272 controls) and 18 studies on IL-10 -819T>C (3,431 cases and 6,109 controls) were selected. Overall, -592A>C polymorphism was associated with the risk of GC under the heterozygote model (OR=1.153, 95% CI=1.020-1.305, p=0.023), but not -819T>C polymorphism. When stratified by ethnicity, significant association was only observed in the Asians under the allele model (OR=1.153, 95% CI=1.007-1.320, p=0.040) and the heterozygote model (OR=1.218, 95% CI=1.076-1.379, p=0.002) for -592A>C. Conclusion: The current meta-analysis results inconsistent with previous meta-analyses; showed that the IL-10 -592A>C polymorphism, but not -819T>C polymorphism, may be contributed to the susceptibility of GC in overall and Asian populations.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202019000100500&tlng=enStomach neoplasmsInterleukin-10Polymorphism, geneticMeta-analysis |
| spellingShingle | Mansour MOGHMI Amir ARJMANDI Kazem AGHILI Mohammadali JAFARI Masoud ZARE-SHEHNEH Shohreh RASTEGAR Seyed Mojtaba ABOLBAGHAEI Hossein NEAMATZADEH ASSOCIATION OF INTERLEUKIN-10 -592A>C AND -819T>C POLYMORPHISMS WITH GASTRIC CANCER RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS OF 44 CASE-CONTROL STUDIES ABCD: Arquivos Brasileiros de Cirurgia Digestiva Stomach neoplasms Interleukin-10 Polymorphism, genetic Meta-analysis |
| title | ASSOCIATION OF INTERLEUKIN-10 -592A>C AND -819T>C POLYMORPHISMS WITH GASTRIC CANCER RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS OF 44 CASE-CONTROL STUDIES |
| title_full | ASSOCIATION OF INTERLEUKIN-10 -592A>C AND -819T>C POLYMORPHISMS WITH GASTRIC CANCER RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS OF 44 CASE-CONTROL STUDIES |
| title_fullStr | ASSOCIATION OF INTERLEUKIN-10 -592A>C AND -819T>C POLYMORPHISMS WITH GASTRIC CANCER RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS OF 44 CASE-CONTROL STUDIES |
| title_full_unstemmed | ASSOCIATION OF INTERLEUKIN-10 -592A>C AND -819T>C POLYMORPHISMS WITH GASTRIC CANCER RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS OF 44 CASE-CONTROL STUDIES |
| title_short | ASSOCIATION OF INTERLEUKIN-10 -592A>C AND -819T>C POLYMORPHISMS WITH GASTRIC CANCER RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS OF 44 CASE-CONTROL STUDIES |
| title_sort | association of interleukin 10 592a c and 819t c polymorphisms with gastric cancer risk a systematic review and meta analysis of 44 case control studies |
| topic | Stomach neoplasms Interleukin-10 Polymorphism, genetic Meta-analysis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202019000100500&tlng=en |
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