GM1 ganglioside exerts protective effects against glutamate‐excitotoxicity via its oligosaccharide in wild‐type and amyotrophic lateral sclerosis motor neurons

GM1 ganglioside exerts protective effects against glutamate‐excitotoxicity via its oligosaccharide in wild‐type and amyotrophic lateral sclerosis motor neurons

Alterations in glycosphingolipid metabolism have been linked to the pathophysiological mechanisms of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons. Accordingly, administration of GM1, a sialic acid‐containing glycosphingolipid, is protective against neurona...

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Bibliographic Details
Main Authors: Giulia Lunghi, Erika Di Biase, Emma Veronica Carsana, Alexandre Henriques, Noelle Callizot, Laura Mauri, Maria Grazia Ciampa, Luigi Mari, Nicoletta Loberto, Massimo Aureli, Sandro Sonnino, Michael Spedding, Elena Chiricozzi, Maria Fazzari
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:FEBS Open Bio
Subjects:
amyotrophic lateral sclerosis
excitotoxicity
GM1 ganglioside
GM1 oligosaccharide
intracellular aggregates
mitochondria
Online Access:https://doi.org/10.1002/2211-5463.13727

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