Correlation of Interleukin-6 Level with Neutrophil to Lymphocyte Ratio and Disease Severity in COVID-19 Patients
Coronavirus disease 2019 (COVID-19) causes severe acute respiratory disease in humans and has spread rapidly worldwide since its first identification in December 2019. The neutrophil-to-lymphocyte ratio (NLR) describes the balance between the severity of inflammation and the immune system to be used...
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| Format: | Article |
| Language: | English |
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Universitas Islam Bandung
2023-04-01
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| Series: | Global Medical & Health Communication |
| Subjects: | |
| Online Access: | https://ejournal.unisba.ac.id/index.php/gmhc/article/view/9643 |
| _version_ | 1797352447152226304 |
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| author | Hendrastutik Apriningsih Nurhasan Agung Prabowo Reviono Reviono Brigitta Devi Anindita Risalina Myrtha Desy Puspa Putri Berty Denny Hermawati |
| author_facet | Hendrastutik Apriningsih Nurhasan Agung Prabowo Reviono Reviono Brigitta Devi Anindita Risalina Myrtha Desy Puspa Putri Berty Denny Hermawati |
| author_sort | Hendrastutik Apriningsih |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) causes severe acute respiratory disease in humans and has spread rapidly worldwide since its first identification in December 2019. The neutrophil-to-lymphocyte ratio (NLR) describes the balance between the severity of inflammation and the immune system to be used as an important systemic inflammatory marker. Rapid progression of clinical deterioration is characterized by severe respiratory symptoms related to high levels of pro-inflammatory cytokines, like interleukin-6 (IL-6), indicating that the occurrence of cytokine storms leads to increased mortality. This study aims to assess the correlation between IL-6 and NLR in predicting the severity of COVID-19. This prospective cohort study was conducted at the COVID-19 ward of Universitas Sebelas Maret Hospital in August–September 2021. This study involved 66 COVID-19 patients >18 years old with asymptomatic to critical degree and Charlson Comorbidity Index (CCI) value ≤3. Examination of laboratory parameters and serum IL-6 was carried out when the patient entered the Emergency Room. Statistical test with Pearson’s correlation test, significant if p<0.05. There is no significant correlation between IL-6 and NLR with p=0.56 and r=0.08, and a strong correlation between IL-6 and disease severity with p=0.000 and r=0.454. The conclusion is that IL-6 does not correlate with NLR and strongly correlates with disease severity in COVID-19 patients. |
| first_indexed | 2024-03-08T13:16:39Z |
| format | Article |
| id | doaj.art-bc9131da81e64e24b4349ce205b885a7 |
| institution | Directory Open Access Journal |
| issn | 2301-9123 2460-5441 |
| language | English |
| last_indexed | 2024-03-08T13:16:39Z |
| publishDate | 2023-04-01 |
| publisher | Universitas Islam Bandung |
| record_format | Article |
| series | Global Medical & Health Communication |
| spelling | doaj.art-bc9131da81e64e24b4349ce205b885a72024-01-18T06:45:54ZengUniversitas Islam BandungGlobal Medical & Health Communication2301-91232460-54412023-04-0111110.29313/gmhc.v11i1.96434765Correlation of Interleukin-6 Level with Neutrophil to Lymphocyte Ratio and Disease Severity in COVID-19 PatientsHendrastutik Apriningsih0Nurhasan Agung Prabowo1Reviono Reviono2Brigitta Devi Anindita3Risalina Myrtha4Desy Puspa Putri5Berty Denny Hermawati6Faculty of Medicine, Universitas Sebelas Maret, SurakartaFaculty of Medicine, Universitas Sebelas Maret, SurakartaFaculty of Medicine, Universitas Sebelas Maret, SurakartaFaculty of Medicine, Universitas Sebelas Maret, SurakartaFaculty of Medicine, Universitas Sebelas Maret, SurakartaFaculty of Medicine, Universitas Sebelas Maret, SurakartaFaculty of Medicine, Universitas Sebelas Maret, SurakartaCoronavirus disease 2019 (COVID-19) causes severe acute respiratory disease in humans and has spread rapidly worldwide since its first identification in December 2019. The neutrophil-to-lymphocyte ratio (NLR) describes the balance between the severity of inflammation and the immune system to be used as an important systemic inflammatory marker. Rapid progression of clinical deterioration is characterized by severe respiratory symptoms related to high levels of pro-inflammatory cytokines, like interleukin-6 (IL-6), indicating that the occurrence of cytokine storms leads to increased mortality. This study aims to assess the correlation between IL-6 and NLR in predicting the severity of COVID-19. This prospective cohort study was conducted at the COVID-19 ward of Universitas Sebelas Maret Hospital in August–September 2021. This study involved 66 COVID-19 patients >18 years old with asymptomatic to critical degree and Charlson Comorbidity Index (CCI) value ≤3. Examination of laboratory parameters and serum IL-6 was carried out when the patient entered the Emergency Room. Statistical test with Pearson’s correlation test, significant if p<0.05. There is no significant correlation between IL-6 and NLR with p=0.56 and r=0.08, and a strong correlation between IL-6 and disease severity with p=0.000 and r=0.454. The conclusion is that IL-6 does not correlate with NLR and strongly correlates with disease severity in COVID-19 patients.https://ejournal.unisba.ac.id/index.php/gmhc/article/view/9643covid-19disease severityinterleukin-6neutrophil-to-lymphocyte ratio |
| spellingShingle | Hendrastutik Apriningsih Nurhasan Agung Prabowo Reviono Reviono Brigitta Devi Anindita Risalina Myrtha Desy Puspa Putri Berty Denny Hermawati Correlation of Interleukin-6 Level with Neutrophil to Lymphocyte Ratio and Disease Severity in COVID-19 Patients Global Medical & Health Communication covid-19 disease severity interleukin-6 neutrophil-to-lymphocyte ratio |
| title | Correlation of Interleukin-6 Level with Neutrophil to Lymphocyte Ratio and Disease Severity in COVID-19 Patients |
| title_full | Correlation of Interleukin-6 Level with Neutrophil to Lymphocyte Ratio and Disease Severity in COVID-19 Patients |
| title_fullStr | Correlation of Interleukin-6 Level with Neutrophil to Lymphocyte Ratio and Disease Severity in COVID-19 Patients |
| title_full_unstemmed | Correlation of Interleukin-6 Level with Neutrophil to Lymphocyte Ratio and Disease Severity in COVID-19 Patients |
| title_short | Correlation of Interleukin-6 Level with Neutrophil to Lymphocyte Ratio and Disease Severity in COVID-19 Patients |
| title_sort | correlation of interleukin 6 level with neutrophil to lymphocyte ratio and disease severity in covid 19 patients |
| topic | covid-19 disease severity interleukin-6 neutrophil-to-lymphocyte ratio |
| url | https://ejournal.unisba.ac.id/index.php/gmhc/article/view/9643 |
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