Pulmonary involvement from animal toxins: the cellular mechanisms
Abstract Venomous animals and their venom have always been of human interest because, despite species differences, coevolution has made them capable of targeting key physiological components of our bodies. Respiratory failure from lung injury is one of the serious consequences of envenomation, and t...
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| Format: | Article |
| Language: | English |
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SciELO
2023-09-01
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| Series: | Journal of Venomous Animals and Toxins including Tropical Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992023000100206&lng=en&tlng=en |
| _version_ | 1797681746533154816 |
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| author | Suthimon Thumtecho Suchai Suteparuk Visith Sitprija |
| author_facet | Suthimon Thumtecho Suchai Suteparuk Visith Sitprija |
| author_sort | Suthimon Thumtecho |
| collection | DOAJ |
| description | Abstract Venomous animals and their venom have always been of human interest because, despite species differences, coevolution has made them capable of targeting key physiological components of our bodies. Respiratory failure from lung injury is one of the serious consequences of envenomation, and the underlying mechanisms are rarely discussed. This review aims to demonstrate how toxins affect the pulmonary system through various biological pathways. Herein, we propose the common underlying cellular mechanisms of toxin-induced lung injury: interference with normal cell function and integrity, disruption of normal vascular function, and provocation of excessive inflammation. Viperid snakebites are the leading cause of envenomation-induced lung injury, followed by other terrestrial venomous animals such as scorpions, spiders, and centipedes. Marine species, particularly jellyfish, can also inflict such injury. Common pulmonary manifestations include pulmonary edema, pulmonary hemorrhage, and exudative infiltration. Severe envenomation can result in acute respiratory distress syndrome. Pulmonary involvement suggests severe envenomation, thus recognizing these mechanisms and manifestations can aid physicians in providing appropriate treatment. |
| first_indexed | 2024-03-11T23:49:29Z |
| format | Article |
| id | doaj.art-bc917c9af3fd4427aeecb060e90d4639 |
| institution | Directory Open Access Journal |
| issn | 1678-9199 |
| language | English |
| last_indexed | 2024-03-11T23:49:29Z |
| publishDate | 2023-09-01 |
| publisher | SciELO |
| record_format | Article |
| series | Journal of Venomous Animals and Toxins including Tropical Diseases |
| spelling | doaj.art-bc917c9af3fd4427aeecb060e90d46392023-09-19T07:46:09ZengSciELOJournal of Venomous Animals and Toxins including Tropical Diseases1678-91992023-09-012910.1590/1678-9199-jvatitd-2023-0026Pulmonary involvement from animal toxins: the cellular mechanismsSuthimon Thumtechohttps://orcid.org/0000-0002-8853-6568Suchai SuteparukVisith Sitprijahttps://orcid.org/0000-0002-2842-9381Abstract Venomous animals and their venom have always been of human interest because, despite species differences, coevolution has made them capable of targeting key physiological components of our bodies. Respiratory failure from lung injury is one of the serious consequences of envenomation, and the underlying mechanisms are rarely discussed. This review aims to demonstrate how toxins affect the pulmonary system through various biological pathways. Herein, we propose the common underlying cellular mechanisms of toxin-induced lung injury: interference with normal cell function and integrity, disruption of normal vascular function, and provocation of excessive inflammation. Viperid snakebites are the leading cause of envenomation-induced lung injury, followed by other terrestrial venomous animals such as scorpions, spiders, and centipedes. Marine species, particularly jellyfish, can also inflict such injury. Common pulmonary manifestations include pulmonary edema, pulmonary hemorrhage, and exudative infiltration. Severe envenomation can result in acute respiratory distress syndrome. Pulmonary involvement suggests severe envenomation, thus recognizing these mechanisms and manifestations can aid physicians in providing appropriate treatment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992023000100206&lng=en&tlng=enlung injuryanimal, toxincellular mechanismpulmonary edemapulmonary hemorrhage |
| spellingShingle | Suthimon Thumtecho Suchai Suteparuk Visith Sitprija Pulmonary involvement from animal toxins: the cellular mechanisms Journal of Venomous Animals and Toxins including Tropical Diseases lung injury animal, toxin cellular mechanism pulmonary edema pulmonary hemorrhage |
| title | Pulmonary involvement from animal toxins: the cellular mechanisms |
| title_full | Pulmonary involvement from animal toxins: the cellular mechanisms |
| title_fullStr | Pulmonary involvement from animal toxins: the cellular mechanisms |
| title_full_unstemmed | Pulmonary involvement from animal toxins: the cellular mechanisms |
| title_short | Pulmonary involvement from animal toxins: the cellular mechanisms |
| title_sort | pulmonary involvement from animal toxins the cellular mechanisms |
| topic | lung injury animal, toxin cellular mechanism pulmonary edema pulmonary hemorrhage |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992023000100206&lng=en&tlng=en |
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