缺血性卒中患者血糖间隙与卒中复发的相关性
Abstract Background Glycemic gap, as a novel index of acute glycemic excursion, is associated with poor prognosis of different diseases. This study aimed to explore the association of the glycemic gap with long‐term stroke recurrence in patients with ischemic stroke. Methods This study included pati...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-09-01
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| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.13432 |
| _version_ | 1797680714472226816 |
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| author | Kang Yuan Mengdi Xie Huajuan Hou Jingjing Chen Xinyi Zhu Huaiming Wang Xiaohao Zhang Yi Xie Min Wu Rui Liu Xinfeng Liu |
| author_facet | Kang Yuan Mengdi Xie Huajuan Hou Jingjing Chen Xinyi Zhu Huaiming Wang Xiaohao Zhang Yi Xie Min Wu Rui Liu Xinfeng Liu |
| author_sort | Kang Yuan |
| collection | DOAJ |
| description | Abstract Background Glycemic gap, as a novel index of acute glycemic excursion, is associated with poor prognosis of different diseases. This study aimed to explore the association of the glycemic gap with long‐term stroke recurrence in patients with ischemic stroke. Methods This study included patients with ischemic stroke from the Nanjing Stroke Registry Program. The glycemic gap was calculated by subtracting the estimated average blood glucose from the blood glucose at admission. Multivariable Cox proportional hazards regression analysis was performed to explore the association between the glycemic gap and the risk of stroke recurrence. The Bayesian hierarchical logistic regression model was used to estimate the effects of the glycemic gap on stroke recurrence stratified by diabetes mellitus and atrial fibrillation. Results Among 2734 enrolled patients, 381 (13.9%) patients experienced stroke recurrence during a median follow‐up of 3.02 years. In multivariate analysis, glycemic gap (high group vs. median group) was associated with significantly increased risk for stroke recurrence (adjusted hazard ratio, 1.488; 95% confidence interval, 1.140–1.942; p = .003) and had varying effects on stroke recurrence depending on atrial fibrillation. The restricted cubic spline curve showed a U‐shaped relationship between the glycemic gap and stroke recurrence (p = .046 for nonlinearity). Conclusion Our study found that the glycemic gap was significantly associated with stroke recurrence in patients with ischemic stroke. The glycemic gap was consistently associated with stroke recurrence across subgroups and had varying effects depending on atrial fibrillation. |
| first_indexed | 2024-03-11T23:34:07Z |
| format | Article |
| id | doaj.art-bc94b2d964df4261898ea88d57560dbd |
| institution | Directory Open Access Journal |
| issn | 1753-0393 1753-0407 |
| language | English |
| last_indexed | 2024-03-11T23:34:07Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj.art-bc94b2d964df4261898ea88d57560dbd2023-09-20T06:15:15ZengWileyJournal of Diabetes1753-03931753-04072023-09-0115971472310.1111/1753-0407.13432缺血性卒中患者血糖间隙与卒中复发的相关性Kang Yuan0Mengdi Xie1Huajuan Hou2Jingjing Chen3Xinyi Zhu4Huaiming Wang5Xiaohao Zhang6Yi Xie7Min Wu8Rui Liu9Xinfeng Liu10Department of Neurology, Nanjing Jinling Hospital Affiliated Hospital of Medical School, Nanjing University Nanjing ChinaDepartment of Neurology, Jinling Hospital Nanjing Medical University Nanjing ChinaDepartment of Neurology, Nanjing Jinling Hospital Affiliated Hospital of Medical School, Nanjing University Nanjing ChinaDepartment of Neurology, Changhai Hospital Navy Medical University Shanghai ChinaDepartment of Neurology, Nanjing Jinling Hospital Affiliated Hospital of Medical School, Nanjing University Nanjing ChinaDepartment of Neurology The 80th Group Army Hospital of The People's Liberation Army Weifang ChinaDepartment of Neurology, Nanjing First Hospital Nanjing Medical University Nanjing ChinaDepartment of Neurology, Nanjing Jinling Hospital Affiliated Hospital of Medical School, Nanjing University Nanjing ChinaDepartment of Neurology, Jinling Hospital Nanjing Medical University Nanjing ChinaDepartment of Neurology, Nanjing Jinling Hospital Affiliated Hospital of Medical School, Nanjing University Nanjing ChinaDepartment of Neurology, Nanjing Jinling Hospital Affiliated Hospital of Medical School, Nanjing University Nanjing ChinaAbstract Background Glycemic gap, as a novel index of acute glycemic excursion, is associated with poor prognosis of different diseases. This study aimed to explore the association of the glycemic gap with long‐term stroke recurrence in patients with ischemic stroke. Methods This study included patients with ischemic stroke from the Nanjing Stroke Registry Program. The glycemic gap was calculated by subtracting the estimated average blood glucose from the blood glucose at admission. Multivariable Cox proportional hazards regression analysis was performed to explore the association between the glycemic gap and the risk of stroke recurrence. The Bayesian hierarchical logistic regression model was used to estimate the effects of the glycemic gap on stroke recurrence stratified by diabetes mellitus and atrial fibrillation. Results Among 2734 enrolled patients, 381 (13.9%) patients experienced stroke recurrence during a median follow‐up of 3.02 years. In multivariate analysis, glycemic gap (high group vs. median group) was associated with significantly increased risk for stroke recurrence (adjusted hazard ratio, 1.488; 95% confidence interval, 1.140–1.942; p = .003) and had varying effects on stroke recurrence depending on atrial fibrillation. The restricted cubic spline curve showed a U‐shaped relationship between the glycemic gap and stroke recurrence (p = .046 for nonlinearity). Conclusion Our study found that the glycemic gap was significantly associated with stroke recurrence in patients with ischemic stroke. The glycemic gap was consistently associated with stroke recurrence across subgroups and had varying effects depending on atrial fibrillation.https://doi.org/10.1111/1753-0407.13432A1C衍生的平均葡萄糖血糖间隙缺血性卒中复发 |
| spellingShingle | Kang Yuan Mengdi Xie Huajuan Hou Jingjing Chen Xinyi Zhu Huaiming Wang Xiaohao Zhang Yi Xie Min Wu Rui Liu Xinfeng Liu 缺血性卒中患者血糖间隙与卒中复发的相关性 Journal of Diabetes A1C衍生的平均葡萄糖 血糖间隙 缺血性卒中 复发 |
| title | 缺血性卒中患者血糖间隙与卒中复发的相关性 |
| title_full | 缺血性卒中患者血糖间隙与卒中复发的相关性 |
| title_fullStr | 缺血性卒中患者血糖间隙与卒中复发的相关性 |
| title_full_unstemmed | 缺血性卒中患者血糖间隙与卒中复发的相关性 |
| title_short | 缺血性卒中患者血糖间隙与卒中复发的相关性 |
| title_sort | 缺血性卒中患者血糖间隙与卒中复发的相关性 |
| topic | A1C衍生的平均葡萄糖 血糖间隙 缺血性卒中 复发 |
| url | https://doi.org/10.1111/1753-0407.13432 |
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