Optofluidic Device Based Microflow Cytometers for Particle/Cell Detection: A Review
Optofluidic devices combining micro-optical and microfluidic components bring a host of new advantages to conventional microfluidic devices. Aspects, such as optical beam shaping, can be integrated on-chip and provide high-sensitivity and built-in optical alignment. Optofluidic microflow cytometers...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-04-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-666X/7/4/70 |
| _version_ | 1818497962781704192 |
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| author | Yushan Zhang Benjamin R. Watts Tianyi Guo Zhiyi Zhang Changqing Xu Qiyin Fang |
| author_facet | Yushan Zhang Benjamin R. Watts Tianyi Guo Zhiyi Zhang Changqing Xu Qiyin Fang |
| author_sort | Yushan Zhang |
| collection | DOAJ |
| description | Optofluidic devices combining micro-optical and microfluidic components bring a host of new advantages to conventional microfluidic devices. Aspects, such as optical beam shaping, can be integrated on-chip and provide high-sensitivity and built-in optical alignment. Optofluidic microflow cytometers have been demonstrated in applications, such as point-of-care diagnostics, cellular immunophenotyping, rare cell analysis, genomics and analytical chemistry. Flow control, light guiding and collecting, data collection and data analysis are the four main techniques attributed to the performance of the optofluidic microflow cytometer. Each of the four areas is discussed in detail to show the basic principles and recent developments. 3D microfabrication techniques are discussed in their use to make these novel microfluidic devices, and the integration of the whole system takes advantage of the miniaturization of each sub-system. The combination of these different techniques is a spur to the development of microflow cytometers, and results show the performance of many types of microflow cytometers developed recently. |
| first_indexed | 2024-12-10T18:51:58Z |
| format | Article |
| id | doaj.art-bc952054bbe34173bbedb49223be47c3 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-12-10T18:51:58Z |
| publishDate | 2016-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-bc952054bbe34173bbedb49223be47c32022-12-22T01:37:17ZengMDPI AGMicromachines2072-666X2016-04-01747010.3390/mi7040070mi7040070Optofluidic Device Based Microflow Cytometers for Particle/Cell Detection: A ReviewYushan Zhang0Benjamin R. Watts1Tianyi Guo2Zhiyi Zhang3Changqing Xu4Qiyin Fang5School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, CanadaArtIC Photonics, 260 Terence Matthews Cres, Ottawa, ON K2M 2C7, CanadaSchool of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, CanadaInformation and Communication Technologies, National Research Council of Canada, 1200 Montreal Road, Ottawa, ON K1A 0R6, CanadaDepartment of Engineering Physics, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, CanadaDepartment of Engineering Physics, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, CanadaOptofluidic devices combining micro-optical and microfluidic components bring a host of new advantages to conventional microfluidic devices. Aspects, such as optical beam shaping, can be integrated on-chip and provide high-sensitivity and built-in optical alignment. Optofluidic microflow cytometers have been demonstrated in applications, such as point-of-care diagnostics, cellular immunophenotyping, rare cell analysis, genomics and analytical chemistry. Flow control, light guiding and collecting, data collection and data analysis are the four main techniques attributed to the performance of the optofluidic microflow cytometer. Each of the four areas is discussed in detail to show the basic principles and recent developments. 3D microfabrication techniques are discussed in their use to make these novel microfluidic devices, and the integration of the whole system takes advantage of the miniaturization of each sub-system. The combination of these different techniques is a spur to the development of microflow cytometers, and results show the performance of many types of microflow cytometers developed recently.http://www.mdpi.com/2072-666X/7/4/70optofluidic devicemicrofluidicsmicroflow cytometermicrofabrication |
| spellingShingle | Yushan Zhang Benjamin R. Watts Tianyi Guo Zhiyi Zhang Changqing Xu Qiyin Fang Optofluidic Device Based Microflow Cytometers for Particle/Cell Detection: A Review Micromachines optofluidic device microfluidics microflow cytometer microfabrication |
| title | Optofluidic Device Based Microflow Cytometers for Particle/Cell Detection: A Review |
| title_full | Optofluidic Device Based Microflow Cytometers for Particle/Cell Detection: A Review |
| title_fullStr | Optofluidic Device Based Microflow Cytometers for Particle/Cell Detection: A Review |
| title_full_unstemmed | Optofluidic Device Based Microflow Cytometers for Particle/Cell Detection: A Review |
| title_short | Optofluidic Device Based Microflow Cytometers for Particle/Cell Detection: A Review |
| title_sort | optofluidic device based microflow cytometers for particle cell detection a review |
| topic | optofluidic device microfluidics microflow cytometer microfabrication |
| url | http://www.mdpi.com/2072-666X/7/4/70 |
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