Morphine Binds Creatine Kinase B and Inhibits Its Activity

Morphine Binds Creatine Kinase B and Inhibits Its Activity

Morphine is an analgesic alkaloid used to relieve severe pain, and irreversible binding of morphine to specific unknown proteins has been previously observed. In the brain, changes in the expression of energy metabolism enzymes contribute to behavioral abnormalities during chronic morphine treatment...

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Bibliographic Details
Main Authors: Ivan Weinsanto, Jinane Mouheiche, Alexis Laux-Biehlmann, François Delalande, Arnaud Marquette, Virginie Chavant, Florian Gabel, Sarah Cianferani, Alexandre Charlet, Marie-Odile Parat, Yannick Goumon
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
morphine
complex
ligand-binding protein
creatine kinase
high affinity
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00464/full

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