Multi-Loop Model of Alzheimer Disease: An Integrated Perspective on the Wnt/GSK3β, α-Synuclein, and Type 3 Diabetes Hypotheses
As the prevalence of Alzheimer disease (AD) continues to rise unabated, new models have been put forth to improve our understanding of this devastating condition. Although individual models may have their merits, integrated models may prove more valuable. Indeed, the reliable failures of monotherapi...
Main Authors: | Nicholas G. Norwitz, Adrian Soto Mota, Sam G. Norwitz, Kieran Clarke |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-07-01
|
Series: | Frontiers in Aging Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2019.00184/full |
Similar Items
-
Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy
by: Yuta Takaichi, et al.
Published: (2020-06-01) -
Multi-loop model of Alzheimer disease: an integrated perspective on the Wnt/GSK3β, α-Synuclein, and type 3 diabetes hypotheses
by: Norwitz, NG, et al.
Published: (2019) -
Morin attenuates tau hyperphosphorylation by inhibiting GSK3β
by: Eun Ji Gong, et al.
Published: (2011-11-01) -
Overexpression of GSK-3β in Adult Tet-OFF GSK-3β Transgenic Mice, and Not During Embryonic or Postnatal Development, Induces Tau Phosphorylation, Neurodegeneration and Learning Deficits
by: Alberto Rodríguez-Matellán, et al.
Published: (2020-09-01) -
Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3β
by: Giulia Povellato, et al.
Published: (2013-11-01)