Recurrence in Plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in South-West India [version 2; peer review: 2 approved]
Background: India is endemic for Plasmodium vivax (Pv) malaria. Despite a decrease in incidence, its elimination is hampered by recurrences. This study aimed to characterize recurrences in Pv malaria and study its association with primaquine (PQ) usage. Methods: Symptomatic adult Pv patients were...
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F1000 Research Ltd
2022-04-01
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| Online Access: | https://f1000research.com/articles/11-279/v2 |
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| author | Vasudeva Guddattu Vishnu Teja Nallapati Divya Gandrala Alekhya Lavu Nitin Gupta Kavitha Saravu |
| author_facet | Vasudeva Guddattu Vishnu Teja Nallapati Divya Gandrala Alekhya Lavu Nitin Gupta Kavitha Saravu |
| author_sort | Vasudeva Guddattu |
| collection | DOAJ |
| description | Background: India is endemic for Plasmodium vivax (Pv) malaria. Despite a decrease in incidence, its elimination is hampered by recurrences. This study aimed to characterize recurrences in Pv malaria and study its association with primaquine (PQ) usage. Methods: Symptomatic adult Pv patients were followed-up for up to 23 months for recurrences. The time to recurrence was compared by the PQ dosage they received using a log-rank test. Results: Of the 294 malaria patients, 206 (70%) patients had Pv infection during the study period. A total of 20 (9.7%) recurrences were seen in 17 (8.2%) patients of Pv. The percentage of first-time recurrences were highest in the no PQ group (25%), followed by the weekly PQ group (20%), low dose daily PQ (8.2%) group, and high dose daily PQ group (3.1%). Conclusions: Recurrence in Pv malaria is common, especially in those who receive an incorrect prescription of primaquine. |
| first_indexed | 2024-12-12T05:56:53Z |
| format | Article |
| id | doaj.art-bc97d3c1f9e345ffbf9f69edba6cc33c |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-12T05:56:53Z |
| publishDate | 2022-04-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-bc97d3c1f9e345ffbf9f69edba6cc33c2022-12-22T00:35:32ZengF1000 Research LtdF1000Research2046-14022022-04-0111123067Recurrence in Plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in South-West India [version 2; peer review: 2 approved]Vasudeva Guddattu0Vishnu Teja Nallapati1Divya Gandrala2Alekhya Lavu3Nitin Gupta4Kavitha Saravu5https://orcid.org/0000-0001-6399-1129Department of Data Science, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaDepartment of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaDepartment of Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaDepartment of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaDepartment of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaDepartment of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaBackground: India is endemic for Plasmodium vivax (Pv) malaria. Despite a decrease in incidence, its elimination is hampered by recurrences. This study aimed to characterize recurrences in Pv malaria and study its association with primaquine (PQ) usage. Methods: Symptomatic adult Pv patients were followed-up for up to 23 months for recurrences. The time to recurrence was compared by the PQ dosage they received using a log-rank test. Results: Of the 294 malaria patients, 206 (70%) patients had Pv infection during the study period. A total of 20 (9.7%) recurrences were seen in 17 (8.2%) patients of Pv. The percentage of first-time recurrences were highest in the no PQ group (25%), followed by the weekly PQ group (20%), low dose daily PQ (8.2%) group, and high dose daily PQ group (3.1%). Conclusions: Recurrence in Pv malaria is common, especially in those who receive an incorrect prescription of primaquine.https://f1000research.com/articles/11-279/v2Primaquine; relapse; severe malariaeng |
| spellingShingle | Vasudeva Guddattu Vishnu Teja Nallapati Divya Gandrala Alekhya Lavu Nitin Gupta Kavitha Saravu Recurrence in Plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in South-West India [version 2; peer review: 2 approved] F1000Research Primaquine; relapse; severe malaria eng |
| title | Recurrence in Plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in South-West India [version 2; peer review: 2 approved] |
| title_full | Recurrence in Plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in South-West India [version 2; peer review: 2 approved] |
| title_fullStr | Recurrence in Plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in South-West India [version 2; peer review: 2 approved] |
| title_full_unstemmed | Recurrence in Plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in South-West India [version 2; peer review: 2 approved] |
| title_short | Recurrence in Plasmodium vivax malaria: a prospective cohort study with long follow-up from a coastal region in South-West India [version 2; peer review: 2 approved] |
| title_sort | recurrence in plasmodium vivax malaria a prospective cohort study with long follow up from a coastal region in south west india version 2 peer review 2 approved |
| topic | Primaquine; relapse; severe malaria eng |
| url | https://f1000research.com/articles/11-279/v2 |
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