Early- and intermediate-term outcome of transarterial embolization for symptomatic hepatic focal nodular hyperplasia
ABSTRACT: Purpose: To evaluate the early- and intermediate-term outcome in patients with symptomatic hepatic focal nodular hyperplasia (FNH) treated with transarterial embolization using bleomycin-iodinated oil and polyvinyl alcohol (PVA) particles.Materials and methods: In this two-center retrospec...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2018-05-01
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| Series: | Journal of Interventional Medicine |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2096360219300213 |
| _version_ | 1818283665774346240 |
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| author | Guodong Zhang Maoqiang Wang Feng Duan Kai Yuan Jieyu Yan Zhongfei Chang |
| author_facet | Guodong Zhang Maoqiang Wang Feng Duan Kai Yuan Jieyu Yan Zhongfei Chang |
| author_sort | Guodong Zhang |
| collection | DOAJ |
| description | ABSTRACT: Purpose: To evaluate the early- and intermediate-term outcome in patients with symptomatic hepatic focal nodular hyperplasia (FNH) treated with transarterial embolization using bleomycin-iodinated oil and polyvinyl alcohol (PVA) particles.Materials and methods: In this two-center retrospective study between January 2005 and December 2013, 27 consecutive patients with symptomatic hepatic FNH underwent superselective catheterization by microcatheter techniques and embolization using bleomycin-iodinated oil combined with PVA. Early-term (3–41 months) follow-up of TAE was performed in terms of symptom control, changes in lesion size, and complications. Intermediate-term (45–112 months) follow-up was carried out to assess symptom control and reinterventions for recurrence.Results: Embolization was performed in 27 patients with 31 lesions. Technical success was achieved in all cases. The follow-up period ranged from three to 112 months. At early-term follow-up, mean lesion diameters were decreased significantly from 6.4±2.7 cm pre-intervention to 3.6±1.8 cm at 3-9 months after embolization (P<0.001). A total of 7 lesions had complete resolution during the whole follow-up period. At intermediate-term follow-up, local recurrence was found in 1 treated lesion at 54-months. Contrast-enhanced scans showed complete lack of residual arterial blood supply in the majority of lesions during the follow-up period. There was no major complication associated with the procedure.Conclusion: Transarterial embolization using bleomycin-iodinated oil and PVA is a feasible, safe and effective alternative in both early- and intermediate-terms for the treatment of symptomatic hepatic FNH. Keywords:: Focal nodular hyperplasia, therapeutic embolization, radiology, interventional, bleomycin |
| first_indexed | 2024-12-13T00:40:31Z |
| format | Article |
| id | doaj.art-bc982e7d5f7542a79fb34b9fea91ed65 |
| institution | Directory Open Access Journal |
| issn | 2096-3602 |
| language | English |
| last_indexed | 2024-12-13T00:40:31Z |
| publishDate | 2018-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Interventional Medicine |
| spelling | doaj.art-bc982e7d5f7542a79fb34b9fea91ed652022-12-22T00:05:08ZengKeAi Communications Co., Ltd.Journal of Interventional Medicine2096-36022018-05-01128691Early- and intermediate-term outcome of transarterial embolization for symptomatic hepatic focal nodular hyperplasiaGuodong Zhang0Maoqiang Wang1Feng Duan2Kai Yuan3Jieyu Yan4Zhongfei Chang5Department of Interventional Radiology, Chinese PLA General Hospital, 28# Fuxing RD, Beijing 100853, China; Department of Interventional Radiology, Shandong medical imaging research institute, Shandong University, 324# Jingwu Rd, Jinan 250021, ChinaDepartment of Interventional Radiology, Chinese PLA General Hospital, 28# Fuxing RD, Beijing 100853, China; Correspondence: Wang MQ, M.D., Department of Interventional Radiology, Chinese PLA General Hospital, Beijing 100853, P.R. China. Email: wangmq@vip.sina.comDepartment of Interventional Radiology, Chinese PLA General Hospital, 28# Fuxing RD, Beijing 100853, ChinaDepartment of Interventional Radiology, Chinese PLA General Hospital, 28# Fuxing RD, Beijing 100853, ChinaDepartment of Interventional Radiology, Chinese PLA General Hospital, 28# Fuxing RD, Beijing 100853, ChinaDepartment of Interventional Radiology, Chinese PLA General Hospital, 28# Fuxing RD, Beijing 100853, ChinaABSTRACT: Purpose: To evaluate the early- and intermediate-term outcome in patients with symptomatic hepatic focal nodular hyperplasia (FNH) treated with transarterial embolization using bleomycin-iodinated oil and polyvinyl alcohol (PVA) particles.Materials and methods: In this two-center retrospective study between January 2005 and December 2013, 27 consecutive patients with symptomatic hepatic FNH underwent superselective catheterization by microcatheter techniques and embolization using bleomycin-iodinated oil combined with PVA. Early-term (3–41 months) follow-up of TAE was performed in terms of symptom control, changes in lesion size, and complications. Intermediate-term (45–112 months) follow-up was carried out to assess symptom control and reinterventions for recurrence.Results: Embolization was performed in 27 patients with 31 lesions. Technical success was achieved in all cases. The follow-up period ranged from three to 112 months. At early-term follow-up, mean lesion diameters were decreased significantly from 6.4±2.7 cm pre-intervention to 3.6±1.8 cm at 3-9 months after embolization (P<0.001). A total of 7 lesions had complete resolution during the whole follow-up period. At intermediate-term follow-up, local recurrence was found in 1 treated lesion at 54-months. Contrast-enhanced scans showed complete lack of residual arterial blood supply in the majority of lesions during the follow-up period. There was no major complication associated with the procedure.Conclusion: Transarterial embolization using bleomycin-iodinated oil and PVA is a feasible, safe and effective alternative in both early- and intermediate-terms for the treatment of symptomatic hepatic FNH. Keywords:: Focal nodular hyperplasia, therapeutic embolization, radiology, interventional, bleomycinhttp://www.sciencedirect.com/science/article/pii/S2096360219300213 |
| spellingShingle | Guodong Zhang Maoqiang Wang Feng Duan Kai Yuan Jieyu Yan Zhongfei Chang Early- and intermediate-term outcome of transarterial embolization for symptomatic hepatic focal nodular hyperplasia Journal of Interventional Medicine |
| title | Early- and intermediate-term outcome of transarterial embolization for symptomatic hepatic focal nodular hyperplasia |
| title_full | Early- and intermediate-term outcome of transarterial embolization for symptomatic hepatic focal nodular hyperplasia |
| title_fullStr | Early- and intermediate-term outcome of transarterial embolization for symptomatic hepatic focal nodular hyperplasia |
| title_full_unstemmed | Early- and intermediate-term outcome of transarterial embolization for symptomatic hepatic focal nodular hyperplasia |
| title_short | Early- and intermediate-term outcome of transarterial embolization for symptomatic hepatic focal nodular hyperplasia |
| title_sort | early and intermediate term outcome of transarterial embolization for symptomatic hepatic focal nodular hyperplasia |
| url | http://www.sciencedirect.com/science/article/pii/S2096360219300213 |
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