Market penetration of Xpert MTB/RIF in high tuberculosis burden countries: A trend analysis from 2014 - 2016 [version 1; referees: 4 approved]
Background: Xpert® MTB/RIF, a rapid tuberculosis (TB) molecular test, was endorsed by the World Health Organization in 2010. Since then, 34.4 million cartridges have been procured under concessional pricing. Although the roll out of this diagnostic is promising, previous studies showed low market pe...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2018-07-01
|
| Series: | Gates Open Research |
| Online Access: | https://gatesopenresearch.org/articles/2-35/v1 |
| _version_ | 1819204456292548608 |
|---|---|
| author | Danielle Cazabon Tripti Pande Sandra Kik Wayne Van Gemert Hojoon Sohn Claudia Denkinger Zhi Zhen Qin Brenda Waning Madhukar Pai |
| author_facet | Danielle Cazabon Tripti Pande Sandra Kik Wayne Van Gemert Hojoon Sohn Claudia Denkinger Zhi Zhen Qin Brenda Waning Madhukar Pai |
| author_sort | Danielle Cazabon |
| collection | DOAJ |
| description | Background: Xpert® MTB/RIF, a rapid tuberculosis (TB) molecular test, was endorsed by the World Health Organization in 2010. Since then, 34.4 million cartridges have been procured under concessional pricing. Although the roll out of this diagnostic is promising, previous studies showed low market penetration. Methods: To assess 3-year trends of market penetration of Xpert MTB/RIF in the public sector, smear and Xpert MTB/RIF volumes for the year 2016 were assessed and policies from 2014-2016 within 22 high-burden countries (HBCs) were studied. A structured questionnaire was sent to representatives of 22 HBCs. The questionnaires assessed the total smear and Xpert MTB/RIF volumes, number of modules and days of operation of GeneXpert machines in National TB Programs (NTPs). Data regarding the use of NTP GeneXpert machines for other diseases and GeneXpert procurement by other disease control programs were collected. Market penetration was estimated by the ratio of total sputum smear volume for initial diagnosis divided by the number of Xpert MTB/RIF tests procured in the public sector. Results: The survey response rate was 21/22 (95%). Smear/Xpert ratios decreased in 17/21 countries and increased in four countries, since 2014. The median ratio decreased from 32.6 (Q1:14.3, Q3: 58.9) in 2014 to 6.0 (Q1: 1.6, Q3: 17.0) in 2016. Nineteen countries (19/19; 100%) were not using GeneXpert machines to their full capacity, however seven countries (7/19; 37%) were running tests for other diseases on their NTP-procured GeneXpert systems in 2017, such as HIV, hepatitis-C virus (HCV), Chlamydia trachomatis, and Neisseria gonorrhoeae. Five (5/15; 33%) countries reported GeneXpert procurement by HIV or HCV programs in 2016 and/or 2017. Conclusions: Our results show a positive trend for Xpert MTB/RIF market penetration in 21 HBC public sectors. However, GeneXpert machines were under-utilized for TB, and inadequately exploited as a multi disease technology. |
| first_indexed | 2024-12-23T04:36:06Z |
| format | Article |
| id | doaj.art-bc99aa3b4e2740d7b15b049320568e2c |
| institution | Directory Open Access Journal |
| issn | 2572-4754 |
| language | English |
| last_indexed | 2024-12-23T04:36:06Z |
| publishDate | 2018-07-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | Gates Open Research |
| spelling | doaj.art-bc99aa3b4e2740d7b15b049320568e2c2022-12-21T17:59:54ZengF1000 Research LtdGates Open Research2572-47542018-07-01210.12688/gatesopenres.12842.113923Market penetration of Xpert MTB/RIF in high tuberculosis burden countries: A trend analysis from 2014 - 2016 [version 1; referees: 4 approved]Danielle Cazabon0Tripti Pande1Sandra Kik2Wayne Van Gemert3Hojoon Sohn4Claudia Denkinger5Zhi Zhen Qin6Brenda Waning7Madhukar Pai8McGill International TB Centre, McGill University, Montreal, QC, CanadaMcGill International TB Centre, McGill University, Montreal, QC, CanadaFoundation for Innovative New Diagnostics, FIND, Geneva, SwitzerlandStop TB Partnership, Geneva, SwitzerlandBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USAFoundation for Innovative New Diagnostics, FIND, Geneva, SwitzerlandStop TB Partnership, Geneva, SwitzerlandStop TB Partnership, Geneva, SwitzerlandEpidemiology & Biostatistics, McGill University, Montreal, QC, CanadaBackground: Xpert® MTB/RIF, a rapid tuberculosis (TB) molecular test, was endorsed by the World Health Organization in 2010. Since then, 34.4 million cartridges have been procured under concessional pricing. Although the roll out of this diagnostic is promising, previous studies showed low market penetration. Methods: To assess 3-year trends of market penetration of Xpert MTB/RIF in the public sector, smear and Xpert MTB/RIF volumes for the year 2016 were assessed and policies from 2014-2016 within 22 high-burden countries (HBCs) were studied. A structured questionnaire was sent to representatives of 22 HBCs. The questionnaires assessed the total smear and Xpert MTB/RIF volumes, number of modules and days of operation of GeneXpert machines in National TB Programs (NTPs). Data regarding the use of NTP GeneXpert machines for other diseases and GeneXpert procurement by other disease control programs were collected. Market penetration was estimated by the ratio of total sputum smear volume for initial diagnosis divided by the number of Xpert MTB/RIF tests procured in the public sector. Results: The survey response rate was 21/22 (95%). Smear/Xpert ratios decreased in 17/21 countries and increased in four countries, since 2014. The median ratio decreased from 32.6 (Q1:14.3, Q3: 58.9) in 2014 to 6.0 (Q1: 1.6, Q3: 17.0) in 2016. Nineteen countries (19/19; 100%) were not using GeneXpert machines to their full capacity, however seven countries (7/19; 37%) were running tests for other diseases on their NTP-procured GeneXpert systems in 2017, such as HIV, hepatitis-C virus (HCV), Chlamydia trachomatis, and Neisseria gonorrhoeae. Five (5/15; 33%) countries reported GeneXpert procurement by HIV or HCV programs in 2016 and/or 2017. Conclusions: Our results show a positive trend for Xpert MTB/RIF market penetration in 21 HBC public sectors. However, GeneXpert machines were under-utilized for TB, and inadequately exploited as a multi disease technology.https://gatesopenresearch.org/articles/2-35/v1 |
| spellingShingle | Danielle Cazabon Tripti Pande Sandra Kik Wayne Van Gemert Hojoon Sohn Claudia Denkinger Zhi Zhen Qin Brenda Waning Madhukar Pai Market penetration of Xpert MTB/RIF in high tuberculosis burden countries: A trend analysis from 2014 - 2016 [version 1; referees: 4 approved] Gates Open Research |
| title | Market penetration of Xpert MTB/RIF in high tuberculosis burden countries: A trend analysis from 2014 - 2016 [version 1; referees: 4 approved] |
| title_full | Market penetration of Xpert MTB/RIF in high tuberculosis burden countries: A trend analysis from 2014 - 2016 [version 1; referees: 4 approved] |
| title_fullStr | Market penetration of Xpert MTB/RIF in high tuberculosis burden countries: A trend analysis from 2014 - 2016 [version 1; referees: 4 approved] |
| title_full_unstemmed | Market penetration of Xpert MTB/RIF in high tuberculosis burden countries: A trend analysis from 2014 - 2016 [version 1; referees: 4 approved] |
| title_short | Market penetration of Xpert MTB/RIF in high tuberculosis burden countries: A trend analysis from 2014 - 2016 [version 1; referees: 4 approved] |
| title_sort | market penetration of xpert mtb rif in high tuberculosis burden countries a trend analysis from 2014 2016 version 1 referees 4 approved |
| url | https://gatesopenresearch.org/articles/2-35/v1 |
| work_keys_str_mv | AT daniellecazabon marketpenetrationofxpertmtbrifinhightuberculosisburdencountriesatrendanalysisfrom20142016version1referees4approved AT triptipande marketpenetrationofxpertmtbrifinhightuberculosisburdencountriesatrendanalysisfrom20142016version1referees4approved AT sandrakik marketpenetrationofxpertmtbrifinhightuberculosisburdencountriesatrendanalysisfrom20142016version1referees4approved AT waynevangemert marketpenetrationofxpertmtbrifinhightuberculosisburdencountriesatrendanalysisfrom20142016version1referees4approved AT hojoonsohn marketpenetrationofxpertmtbrifinhightuberculosisburdencountriesatrendanalysisfrom20142016version1referees4approved AT claudiadenkinger marketpenetrationofxpertmtbrifinhightuberculosisburdencountriesatrendanalysisfrom20142016version1referees4approved AT zhizhenqin marketpenetrationofxpertmtbrifinhightuberculosisburdencountriesatrendanalysisfrom20142016version1referees4approved AT brendawaning marketpenetrationofxpertmtbrifinhightuberculosisburdencountriesatrendanalysisfrom20142016version1referees4approved AT madhukarpai marketpenetrationofxpertmtbrifinhightuberculosisburdencountriesatrendanalysisfrom20142016version1referees4approved |