Association between radiotherapy and risk of death from cardiovascular diseases in lung and bronchus cancer
BackgroundRadiotherapy plays an important role in the treatment of lung cancer. However, radiation-related deaths from cardiovascular disease (CVD) are a concern in these patients, and few studies have examined CVD-related death associated with lung cancer. We aimed to evaluate the risk of CVD-relat...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1068957/full |
| _version_ | 1828066535613136896 |
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| author | Zhong Yi Yu Zhang Yu Zhang Yu Zhang Yu Zhang Yu Wang Yun Gao Yanhong Wang Xiangnan Li Songwei Ru Na Guo Jingxuan Qiu Meng Zhang |
| author_facet | Zhong Yi Yu Zhang Yu Zhang Yu Zhang Yu Zhang Yu Wang Yun Gao Yanhong Wang Xiangnan Li Songwei Ru Na Guo Jingxuan Qiu Meng Zhang |
| author_sort | Zhong Yi |
| collection | DOAJ |
| description | BackgroundRadiotherapy plays an important role in the treatment of lung cancer. However, radiation-related deaths from cardiovascular disease (CVD) are a concern in these patients, and few studies have examined CVD-related death associated with lung cancer. We aimed to evaluate the risk of CVD-related death after radiotherapy in patients with lung and bronchus cancer.MethodsData were extracted from the surveillance, epidemiology, and end results database. Propensity score matching (PSM) was applied to reduce possible bias between patients who received radiotherapy and those who did not. The Kaplan–Meier method was used to estimate cardiovascular-specific survival (CVSS), and the log-rank test was used to compare CVSS between the radiotherapy and no radiotherapy groups. Cox proportional hazards regression analysis was performed to estimate the hazard ratio (HR) of CVD-related death.ResultsA total of 225,570 patients with lung and bronchus cancer were included, and 201,282 patients remained after PSM. Radiotherapy was identified as an independent risk factor for CVSS among patients with lung and bronchus cancer before PSM (HR: 1.18, P < 0.001) and after PSM (HR: 1.18, P < 0.001). Patients treated with radiotherapy had a significantly worse CVSS than those who did not receive radiotherapy before PSM (25-year CVSS: 49.9 vs. 56.4%, P = 0.002) and after PSM (25-year CVSS: 48.4 vs. 56.7%, P < 0.001). Radiotherapy was associated with more deaths from heart disease before PSM (81.9 vs. 77.2%, P < 0.001) and after PSM (83.0 vs. 78.7%, P < 0.001).ConclusionRadiotherapy is associated with an increased risk of CVD-related death, especially death from heart disease, in patients with lung and bronchus cancer. More efforts are needed to monitor cardiovascular health after radiotherapy. |
| first_indexed | 2024-04-10T23:32:09Z |
| format | Article |
| id | doaj.art-bc9a02630f3d44ef9fae4d053b795d9e |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-10T23:32:09Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-bc9a02630f3d44ef9fae4d053b795d9e2023-01-12T05:33:21ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-01-01910.3389/fcvm.2022.10689571068957Association between radiotherapy and risk of death from cardiovascular diseases in lung and bronchus cancerZhong Yi0Yu Zhang1Yu Zhang2Yu Zhang3Yu Zhang4Yu Wang5Yun Gao6Yanhong Wang7Xiangnan Li8Songwei Ru9Na Guo10Jingxuan Qiu11Meng Zhang12Department of Geriatrics, Aerospace Center Hospital, Beijing, ChinaInstitute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences, Beijing, ChinaComparative Medicine Center, Peking Union Medical College, Beijing, ChinaNational Human Diseases Animal Model Resource Center, Beijing, ChinaNational Health Committee (NHC) Key Laboratory of Human Disease Comparative Medicine, Beijing, ChinaDepartment of Geriatrics, Aerospace Center Hospital, Beijing, ChinaDepartment of Geriatrics, Aerospace Center Hospital, Beijing, ChinaDepartment of Geriatrics, Aerospace Center Hospital, Beijing, ChinaDepartment of Geriatrics, Aerospace Center Hospital, Beijing, ChinaDepartment of Geriatrics, Aerospace Center Hospital, Beijing, ChinaDepartment of Geriatrics, Aerospace Center Hospital, Beijing, ChinaDepartment of Geriatrics, Aerospace Center Hospital, Beijing, ChinaDepartment of Cardiovascular, Aerospace Center Hospital, Beijing, ChinaBackgroundRadiotherapy plays an important role in the treatment of lung cancer. However, radiation-related deaths from cardiovascular disease (CVD) are a concern in these patients, and few studies have examined CVD-related death associated with lung cancer. We aimed to evaluate the risk of CVD-related death after radiotherapy in patients with lung and bronchus cancer.MethodsData were extracted from the surveillance, epidemiology, and end results database. Propensity score matching (PSM) was applied to reduce possible bias between patients who received radiotherapy and those who did not. The Kaplan–Meier method was used to estimate cardiovascular-specific survival (CVSS), and the log-rank test was used to compare CVSS between the radiotherapy and no radiotherapy groups. Cox proportional hazards regression analysis was performed to estimate the hazard ratio (HR) of CVD-related death.ResultsA total of 225,570 patients with lung and bronchus cancer were included, and 201,282 patients remained after PSM. Radiotherapy was identified as an independent risk factor for CVSS among patients with lung and bronchus cancer before PSM (HR: 1.18, P < 0.001) and after PSM (HR: 1.18, P < 0.001). Patients treated with radiotherapy had a significantly worse CVSS than those who did not receive radiotherapy before PSM (25-year CVSS: 49.9 vs. 56.4%, P = 0.002) and after PSM (25-year CVSS: 48.4 vs. 56.7%, P < 0.001). Radiotherapy was associated with more deaths from heart disease before PSM (81.9 vs. 77.2%, P < 0.001) and after PSM (83.0 vs. 78.7%, P < 0.001).ConclusionRadiotherapy is associated with an increased risk of CVD-related death, especially death from heart disease, in patients with lung and bronchus cancer. More efforts are needed to monitor cardiovascular health after radiotherapy.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1068957/fulllung and bronchuscancerradiotherapycardiovascular diseasesdeath |
| spellingShingle | Zhong Yi Yu Zhang Yu Zhang Yu Zhang Yu Zhang Yu Wang Yun Gao Yanhong Wang Xiangnan Li Songwei Ru Na Guo Jingxuan Qiu Meng Zhang Association between radiotherapy and risk of death from cardiovascular diseases in lung and bronchus cancer Frontiers in Cardiovascular Medicine lung and bronchus cancer radiotherapy cardiovascular diseases death |
| title | Association between radiotherapy and risk of death from cardiovascular diseases in lung and bronchus cancer |
| title_full | Association between radiotherapy and risk of death from cardiovascular diseases in lung and bronchus cancer |
| title_fullStr | Association between radiotherapy and risk of death from cardiovascular diseases in lung and bronchus cancer |
| title_full_unstemmed | Association between radiotherapy and risk of death from cardiovascular diseases in lung and bronchus cancer |
| title_short | Association between radiotherapy and risk of death from cardiovascular diseases in lung and bronchus cancer |
| title_sort | association between radiotherapy and risk of death from cardiovascular diseases in lung and bronchus cancer |
| topic | lung and bronchus cancer radiotherapy cardiovascular diseases death |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1068957/full |
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