Exploring the Diverse Immune and Genetic Landscape of Psoriatic Arthritis
Psoriatic arthritis (PsA) is characterized by delays in diagnosis and modest effect of treatment in terms of joint response. An understanding of molecular pathomechanisms may aid in developing diagnostic and prognostic models. Genetic susceptibility (e.g., HLA class I genes, IL-23-related genes) can...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/10/24/5926 |
| _version_ | 1797503467723423744 |
|---|---|
| author | Bogdan Batko |
| author_facet | Bogdan Batko |
| author_sort | Bogdan Batko |
| collection | DOAJ |
| description | Psoriatic arthritis (PsA) is characterized by delays in diagnosis and modest effect of treatment in terms of joint response. An understanding of molecular pathomechanisms may aid in developing diagnostic and prognostic models. Genetic susceptibility (e.g., HLA class I genes, IL-23-related genes) can be responsible for the pattern of psoriatic manifestations and affinity for tissue involvement. Gene expression analysis indicates an inflammatory profile that is distinct for PsA, but disparate across tissues. This has clinical implications, as for example, dual blockade of IL-17A and IL-17F can lead to superior clinical effects if there is differential expression of IL-17 receptors in tissues. Structural and functional impairment of barrier tissue, including host-microbiome interactions, may be the source of immune activation. Interplay between different cell populations of innate and adaptive immunity is emerging, potentially providing a link between the transition of skin-to-joint disease. Th17 subsets, IL-17A, IL-17F and IL-23 are crucial in PsA pathogenesis, with both clinical and experimental evidence suggesting a differential molecular landscape in cutaneous and articular compartments. |
| first_indexed | 2024-03-10T03:51:06Z |
| format | Article |
| id | doaj.art-bc9c3ae871914175b5653c3fff65bfcb |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T03:51:06Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-bc9c3ae871914175b5653c3fff65bfcb2023-11-23T08:58:13ZengMDPI AGJournal of Clinical Medicine2077-03832021-12-011024592610.3390/jcm10245926Exploring the Diverse Immune and Genetic Landscape of Psoriatic ArthritisBogdan Batko0Department of Rheumatology and Immunology, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski University, 30-705 Krakow, PolandPsoriatic arthritis (PsA) is characterized by delays in diagnosis and modest effect of treatment in terms of joint response. An understanding of molecular pathomechanisms may aid in developing diagnostic and prognostic models. Genetic susceptibility (e.g., HLA class I genes, IL-23-related genes) can be responsible for the pattern of psoriatic manifestations and affinity for tissue involvement. Gene expression analysis indicates an inflammatory profile that is distinct for PsA, but disparate across tissues. This has clinical implications, as for example, dual blockade of IL-17A and IL-17F can lead to superior clinical effects if there is differential expression of IL-17 receptors in tissues. Structural and functional impairment of barrier tissue, including host-microbiome interactions, may be the source of immune activation. Interplay between different cell populations of innate and adaptive immunity is emerging, potentially providing a link between the transition of skin-to-joint disease. Th17 subsets, IL-17A, IL-17F and IL-23 are crucial in PsA pathogenesis, with both clinical and experimental evidence suggesting a differential molecular landscape in cutaneous and articular compartments.https://www.mdpi.com/2077-0383/10/24/5926psoriatic arthritisinflammationinterleukin-17interleukin-23pathomechanismmodulation |
| spellingShingle | Bogdan Batko Exploring the Diverse Immune and Genetic Landscape of Psoriatic Arthritis Journal of Clinical Medicine psoriatic arthritis inflammation interleukin-17 interleukin-23 pathomechanism modulation |
| title | Exploring the Diverse Immune and Genetic Landscape of Psoriatic Arthritis |
| title_full | Exploring the Diverse Immune and Genetic Landscape of Psoriatic Arthritis |
| title_fullStr | Exploring the Diverse Immune and Genetic Landscape of Psoriatic Arthritis |
| title_full_unstemmed | Exploring the Diverse Immune and Genetic Landscape of Psoriatic Arthritis |
| title_short | Exploring the Diverse Immune and Genetic Landscape of Psoriatic Arthritis |
| title_sort | exploring the diverse immune and genetic landscape of psoriatic arthritis |
| topic | psoriatic arthritis inflammation interleukin-17 interleukin-23 pathomechanism modulation |
| url | https://www.mdpi.com/2077-0383/10/24/5926 |
| work_keys_str_mv | AT bogdanbatko exploringthediverseimmuneandgeneticlandscapeofpsoriaticarthritis |