Immunohistochemical localization of notch signaling molecules in ameloblastomas
<p>Abstract</p> <p>We examined Notch signaling molecules, Notch1 and Jagged1, in serial large cases of typical solid/multicystic ameloblastoma. In general, Notch positive staining products were frequently detected in the cytoplasms of the cells. In the same cells, Jagged positive s...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-06-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | http://www.eurjmedres.com/content/16/6/253 |
| _version_ | 1828419528359411712 |
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| author | Muraki E Nakano K Maeda H Takayama M Jinno M Kubo K Yoshida W Hasegawa H Kawakami T |
| author_facet | Muraki E Nakano K Maeda H Takayama M Jinno M Kubo K Yoshida W Hasegawa H Kawakami T |
| author_sort | Muraki E |
| collection | DOAJ |
| description | <p>Abstract</p> <p>We examined Notch signaling molecules, Notch1 and Jagged1, in serial large cases of typical solid/multicystic ameloblastoma. In general, Notch positive staining products were frequently detected in the cytoplasms of the cells. In the same cells, Jagged positive staining were also frequently observed, while only occasionally positive in peripheral cells, especially in cuboidal cells. The results showed that these morphogenesis regulation factors are closely related to cytological differentiation in neoplastic cells of ameloblastoma. The Notch and Jagged positive-cell ratios were frequently positive, and the ratios were nearly the same between the varied histopathological, cytological patterns. However, the less-differentiated cells were fewer in number than that of well-differentiated cells.</p> |
| first_indexed | 2024-12-10T14:55:02Z |
| format | Article |
| id | doaj.art-bc9d50437cd84ba3820683713c869b72 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-12-10T14:55:02Z |
| publishDate | 2011-06-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-bc9d50437cd84ba3820683713c869b722022-12-22T01:44:20ZengBMCEuropean Journal of Medical Research2047-783X2011-06-0116625310.1186/2047-783X-16-6-253Immunohistochemical localization of notch signaling molecules in ameloblastomasMuraki ENakano KMaeda HTakayama MJinno MKubo KYoshida WHasegawa HKawakami T<p>Abstract</p> <p>We examined Notch signaling molecules, Notch1 and Jagged1, in serial large cases of typical solid/multicystic ameloblastoma. In general, Notch positive staining products were frequently detected in the cytoplasms of the cells. In the same cells, Jagged positive staining were also frequently observed, while only occasionally positive in peripheral cells, especially in cuboidal cells. The results showed that these morphogenesis regulation factors are closely related to cytological differentiation in neoplastic cells of ameloblastoma. The Notch and Jagged positive-cell ratios were frequently positive, and the ratios were nearly the same between the varied histopathological, cytological patterns. However, the less-differentiated cells were fewer in number than that of well-differentiated cells.</p>http://www.eurjmedres.com/content/16/6/253AmeloblastomaNotch signalingNotch JaggedCell differentiationImmunohistochemistry |
| spellingShingle | Muraki E Nakano K Maeda H Takayama M Jinno M Kubo K Yoshida W Hasegawa H Kawakami T Immunohistochemical localization of notch signaling molecules in ameloblastomas European Journal of Medical Research Ameloblastoma Notch signaling Notch Jagged Cell differentiation Immunohistochemistry |
| title | Immunohistochemical localization of notch signaling molecules in ameloblastomas |
| title_full | Immunohistochemical localization of notch signaling molecules in ameloblastomas |
| title_fullStr | Immunohistochemical localization of notch signaling molecules in ameloblastomas |
| title_full_unstemmed | Immunohistochemical localization of notch signaling molecules in ameloblastomas |
| title_short | Immunohistochemical localization of notch signaling molecules in ameloblastomas |
| title_sort | immunohistochemical localization of notch signaling molecules in ameloblastomas |
| topic | Ameloblastoma Notch signaling Notch Jagged Cell differentiation Immunohistochemistry |
| url | http://www.eurjmedres.com/content/16/6/253 |
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