Cytotoxic and Cytolytic Cnidarian Venoms. A Review on Health Implications and Possible Therapeutic Applications
The toxicity of Cnidaria is a subject of concern for its influence on human activities and public health. During the last decades, the mechanisms of cell injury caused by cnidarian venoms have been studied utilizing extracts from several Cnidaria that have been tested in order to evaluate some funda...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-12-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6651/6/1/108 |
| _version_ | 1817996595579322368 |
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| author | Gian Luigi Mariottini Luigi Pane |
| author_facet | Gian Luigi Mariottini Luigi Pane |
| author_sort | Gian Luigi Mariottini |
| collection | DOAJ |
| description | The toxicity of Cnidaria is a subject of concern for its influence on human activities and public health. During the last decades, the mechanisms of cell injury caused by cnidarian venoms have been studied utilizing extracts from several Cnidaria that have been tested in order to evaluate some fundamental parameters, such as the activity on cell survival, functioning and metabolism, and to improve the knowledge about the mechanisms of action of these compounds. In agreement with the modern tendency aimed to avoid the utilization of living animals in the experiments and to substitute them with in vitro systems, established cell lines or primary cultures have been employed to test cnidarian extracts or derivatives. Several cnidarian venoms have been found to have cytotoxic properties and have been also shown to cause hemolytic effects. Some studied substances have been shown to affect tumour cells and microorganisms, so making cnidarian extracts particularly interesting for their possible therapeutic employment. The review aims to emphasize the up-to-date knowledge about this subject taking in consideration the importance of such venoms in human pathology, the health implications and the possible therapeutic application of these natural compounds. |
| first_indexed | 2024-04-14T02:25:50Z |
| format | Article |
| id | doaj.art-bc9d5204d84d4990a43071718931c83b |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-14T02:25:50Z |
| publishDate | 2013-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-bc9d5204d84d4990a43071718931c83b2022-12-22T02:17:54ZengMDPI AGToxins2072-66512013-12-016110815110.3390/toxins6010108toxins6010108Cytotoxic and Cytolytic Cnidarian Venoms. A Review on Health Implications and Possible Therapeutic ApplicationsGian Luigi Mariottini0Luigi Pane1Department of Earth, Environment and Life Sciences, University of Genova, Viale Benedetto XV 5, Genova I-16132, ItalyDepartment of Earth, Environment and Life Sciences, University of Genova, Viale Benedetto XV 5, Genova I-16132, ItalyThe toxicity of Cnidaria is a subject of concern for its influence on human activities and public health. During the last decades, the mechanisms of cell injury caused by cnidarian venoms have been studied utilizing extracts from several Cnidaria that have been tested in order to evaluate some fundamental parameters, such as the activity on cell survival, functioning and metabolism, and to improve the knowledge about the mechanisms of action of these compounds. In agreement with the modern tendency aimed to avoid the utilization of living animals in the experiments and to substitute them with in vitro systems, established cell lines or primary cultures have been employed to test cnidarian extracts or derivatives. Several cnidarian venoms have been found to have cytotoxic properties and have been also shown to cause hemolytic effects. Some studied substances have been shown to affect tumour cells and microorganisms, so making cnidarian extracts particularly interesting for their possible therapeutic employment. The review aims to emphasize the up-to-date knowledge about this subject taking in consideration the importance of such venoms in human pathology, the health implications and the possible therapeutic application of these natural compounds.http://www.mdpi.com/2072-6651/6/1/108Cnidariavenomcytotoxicitycell cultures |
| spellingShingle | Gian Luigi Mariottini Luigi Pane Cytotoxic and Cytolytic Cnidarian Venoms. A Review on Health Implications and Possible Therapeutic Applications Toxins Cnidaria venom cytotoxicity cell cultures |
| title | Cytotoxic and Cytolytic Cnidarian Venoms. A Review on Health Implications and Possible Therapeutic Applications |
| title_full | Cytotoxic and Cytolytic Cnidarian Venoms. A Review on Health Implications and Possible Therapeutic Applications |
| title_fullStr | Cytotoxic and Cytolytic Cnidarian Venoms. A Review on Health Implications and Possible Therapeutic Applications |
| title_full_unstemmed | Cytotoxic and Cytolytic Cnidarian Venoms. A Review on Health Implications and Possible Therapeutic Applications |
| title_short | Cytotoxic and Cytolytic Cnidarian Venoms. A Review on Health Implications and Possible Therapeutic Applications |
| title_sort | cytotoxic and cytolytic cnidarian venoms a review on health implications and possible therapeutic applications |
| topic | Cnidaria venom cytotoxicity cell cultures |
| url | http://www.mdpi.com/2072-6651/6/1/108 |
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