Cathepsin B-Deficient Mice Resolve Leishmania major Inflammation Faster in a T Cell-Dependent Manner.

Cathepsin B-Deficient Mice Resolve Leishmania major Inflammation Faster in a T Cell-Dependent Manner.

A critical role for intracellular TLR9 has been described in recognition and host resistance to Leishmania parasites. As TLR9 requires endolysosomal proteolytic cleavage to achieve signaling functionality, we investigated the contribution of different proteases like asparagine endopeptidase (AEP) or...

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Bibliographic Details
Main Authors: Orhan Rasid, Véronique Mériaux, Erin M Khan, Chloé Borde, Ioana S Ciulean, Catherine Fitting, Bénédicte Manoury, Jean-Marc Cavaillon, Noëlle Doyen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-05-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4868322?pdf=render

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