Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system
Encapsulation and controlled release of substances using polymeric nanoparticles require that these have a high reproducibility, homogeneity, and control over their properties, especially when they are to be used in medical, pharmaceutical or nutritional applications among others. This work shows a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Universidad Nacional de Colombia
2018-01-01
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| Series: | Dyna |
| Subjects: | |
| Online Access: | https://revistas.unal.edu.co/index.php/dyna/article/view/62292 |
| _version_ | 1811265395140591616 |
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| author | Gabriel Jaime Colmenares-Roldan Liliana Maria Agudelo-Gomez Rodolfo Pinal Lina Marcela Hoyos Palacio |
| author_facet | Gabriel Jaime Colmenares-Roldan Liliana Maria Agudelo-Gomez Rodolfo Pinal Lina Marcela Hoyos Palacio |
| author_sort | Gabriel Jaime Colmenares-Roldan |
| collection | DOAJ |
| description | Encapsulation and controlled release of substances using polymeric nanoparticles require that these have a high reproducibility, homogeneity, and control over their properties, especially when they are to be used in medical, pharmaceutical or nutritional applications among others. This work shows a high productivity system to synthesize nanoparticles in an easy, fast and controlled way. This study shows the effect of molecular weight of the polymer, the type of surfactant and the relationship between the volumes of the aqueous and the organic phases. It was found that the first two variables have a statistically significant effect on the diameter of the nanoparticles while the relationship between the volume of the aqueous phase and the organic phase does not significantly affect the diameter of the nanoparticles. Additionally, it was found that none of the three variables significantly affects the polydispersity index (PI) of the nanoparticles. |
| first_indexed | 2024-04-12T20:21:52Z |
| format | Article |
| id | doaj.art-bca0bf8b1cd14d14a19c32d08e7c7814 |
| institution | Directory Open Access Journal |
| issn | 0012-7353 2346-2183 |
| language | English |
| last_indexed | 2024-04-12T20:21:52Z |
| publishDate | 2018-01-01 |
| publisher | Universidad Nacional de Colombia |
| record_format | Article |
| series | Dyna |
| spelling | doaj.art-bca0bf8b1cd14d14a19c32d08e7c78142022-12-22T03:17:58ZengUniversidad Nacional de ColombiaDyna0012-73532346-21832018-01-018520427728210.15446/dyna.v85n204.6229247796Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating systemGabriel Jaime Colmenares-Roldan0Liliana Maria Agudelo-Gomez1Rodolfo Pinal2Lina Marcela Hoyos Palacio3Universidad Pontificia BolivarianaUniversidad Pontificia BolivarianaPurdue UniversityUniversidad Pontificia BolivarianaEncapsulation and controlled release of substances using polymeric nanoparticles require that these have a high reproducibility, homogeneity, and control over their properties, especially when they are to be used in medical, pharmaceutical or nutritional applications among others. This work shows a high productivity system to synthesize nanoparticles in an easy, fast and controlled way. This study shows the effect of molecular weight of the polymer, the type of surfactant and the relationship between the volumes of the aqueous and the organic phases. It was found that the first two variables have a statistically significant effect on the diameter of the nanoparticles while the relationship between the volume of the aqueous phase and the organic phase does not significantly affect the diameter of the nanoparticles. Additionally, it was found that none of the three variables significantly affects the polydispersity index (PI) of the nanoparticles.https://revistas.unal.edu.co/index.php/dyna/article/view/62292nanoparticlespolycaprolactonenanoprecipitationencapsulationdelivery |
| spellingShingle | Gabriel Jaime Colmenares-Roldan Liliana Maria Agudelo-Gomez Rodolfo Pinal Lina Marcela Hoyos Palacio Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system Dyna nanoparticles polycaprolactone nanoprecipitation encapsulation delivery |
| title | Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system |
| title_full | Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system |
| title_fullStr | Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system |
| title_full_unstemmed | Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system |
| title_short | Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system |
| title_sort | production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system |
| topic | nanoparticles polycaprolactone nanoprecipitation encapsulation delivery |
| url | https://revistas.unal.edu.co/index.php/dyna/article/view/62292 |
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