Social Cognition Impairments in Association to Clinical, Cognitive, Mood, and Fatigue Features in Multiple Sclerosis: A Study Protocol
Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS), characterized by the diffuse grey and white matter damage. Cognitive impairment (CI) is a frequent clinical feature in patients with MS (PwMS) that can be prevalent even in early disease stages, affecti...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
|
| Series: | Neurology International |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2035-8377/15/3/68 |
| _version_ | 1827724941174243328 |
|---|---|
| author | Triantafyllos K. Doskas Foteini Christidi Kanellos C. Spiliopoulos Dimitrios Tsiptsios George D. Vavougios Anna Tsiakiri Theofanis Vorvolakos Christos Kokkotis Ioannis Iliopoulos Nikolaos Aggelousis Konstantinos Vadikolias |
| author_facet | Triantafyllos K. Doskas Foteini Christidi Kanellos C. Spiliopoulos Dimitrios Tsiptsios George D. Vavougios Anna Tsiakiri Theofanis Vorvolakos Christos Kokkotis Ioannis Iliopoulos Nikolaos Aggelousis Konstantinos Vadikolias |
| author_sort | Triantafyllos K. Doskas |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS), characterized by the diffuse grey and white matter damage. Cognitive impairment (CI) is a frequent clinical feature in patients with MS (PwMS) that can be prevalent even in early disease stages, affecting the physical activity and active social participation of PwMS. Limited information is available regarding the influence of MS in social cognition (SC), which may occur independently from the overall neurocognitive dysfunction. In addition, the available information regarding the factors that influence SC in PwMS is limited, e.g., factors such as a patient’s physical disability, different cognitive phenotypes, mood status, fatigue. Considering that SC is an important domain of CI in MS and may contribute to subjects’ social participation and quality of life, we herein conceptualize and present the methodological design of a cross-sectional study in 100 PwMS of different disease subtypes. The study aims (a) to characterize SC impairment in PwMS in the Greek population and (b) to unveil the relationship between clinical symptoms, phenotypes of CI, mood status and fatigue in PwMS and the potential underlying impairment on tasks of SC. |
| first_indexed | 2024-03-10T22:21:36Z |
| format | Article |
| id | doaj.art-bca1fe05b943418b85e6451ed496cdfa |
| institution | Directory Open Access Journal |
| issn | 2035-8377 |
| language | English |
| last_indexed | 2024-03-10T22:21:36Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj.art-bca1fe05b943418b85e6451ed496cdfa2023-11-19T12:15:57ZengMDPI AGNeurology International2035-83772023-09-011531106111610.3390/neurolint15030068Social Cognition Impairments in Association to Clinical, Cognitive, Mood, and Fatigue Features in Multiple Sclerosis: A Study ProtocolTriantafyllos K. Doskas0Foteini Christidi1Kanellos C. Spiliopoulos2Dimitrios Tsiptsios3George D. Vavougios4Anna Tsiakiri5Theofanis Vorvolakos6Christos Kokkotis7Ioannis Iliopoulos8Nikolaos Aggelousis9Konstantinos Vadikolias10Neurology Department, Athens Naval Hospital, 11521 Athens, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, Athens Naval Hospital, 11521 Athens, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, University of Cyprus, 20537 Nicosia, CyprusNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreecePsychiatry Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceDepartment of Physical Education and Sport Science, Democritus University of Thrace, 69100 Komotini, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceDepartment of Physical Education and Sport Science, Democritus University of Thrace, 69100 Komotini, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceMultiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS), characterized by the diffuse grey and white matter damage. Cognitive impairment (CI) is a frequent clinical feature in patients with MS (PwMS) that can be prevalent even in early disease stages, affecting the physical activity and active social participation of PwMS. Limited information is available regarding the influence of MS in social cognition (SC), which may occur independently from the overall neurocognitive dysfunction. In addition, the available information regarding the factors that influence SC in PwMS is limited, e.g., factors such as a patient’s physical disability, different cognitive phenotypes, mood status, fatigue. Considering that SC is an important domain of CI in MS and may contribute to subjects’ social participation and quality of life, we herein conceptualize and present the methodological design of a cross-sectional study in 100 PwMS of different disease subtypes. The study aims (a) to characterize SC impairment in PwMS in the Greek population and (b) to unveil the relationship between clinical symptoms, phenotypes of CI, mood status and fatigue in PwMS and the potential underlying impairment on tasks of SC.https://www.mdpi.com/2035-8377/15/3/68multiple sclerosissocial cognitionmoodfatiguecognitive impairment |
| spellingShingle | Triantafyllos K. Doskas Foteini Christidi Kanellos C. Spiliopoulos Dimitrios Tsiptsios George D. Vavougios Anna Tsiakiri Theofanis Vorvolakos Christos Kokkotis Ioannis Iliopoulos Nikolaos Aggelousis Konstantinos Vadikolias Social Cognition Impairments in Association to Clinical, Cognitive, Mood, and Fatigue Features in Multiple Sclerosis: A Study Protocol Neurology International multiple sclerosis social cognition mood fatigue cognitive impairment |
| title | Social Cognition Impairments in Association to Clinical, Cognitive, Mood, and Fatigue Features in Multiple Sclerosis: A Study Protocol |
| title_full | Social Cognition Impairments in Association to Clinical, Cognitive, Mood, and Fatigue Features in Multiple Sclerosis: A Study Protocol |
| title_fullStr | Social Cognition Impairments in Association to Clinical, Cognitive, Mood, and Fatigue Features in Multiple Sclerosis: A Study Protocol |
| title_full_unstemmed | Social Cognition Impairments in Association to Clinical, Cognitive, Mood, and Fatigue Features in Multiple Sclerosis: A Study Protocol |
| title_short | Social Cognition Impairments in Association to Clinical, Cognitive, Mood, and Fatigue Features in Multiple Sclerosis: A Study Protocol |
| title_sort | social cognition impairments in association to clinical cognitive mood and fatigue features in multiple sclerosis a study protocol |
| topic | multiple sclerosis social cognition mood fatigue cognitive impairment |
| url | https://www.mdpi.com/2035-8377/15/3/68 |
| work_keys_str_mv | AT triantafylloskdoskas socialcognitionimpairmentsinassociationtoclinicalcognitivemoodandfatiguefeaturesinmultiplesclerosisastudyprotocol AT foteinichristidi socialcognitionimpairmentsinassociationtoclinicalcognitivemoodandfatiguefeaturesinmultiplesclerosisastudyprotocol AT kanelloscspiliopoulos socialcognitionimpairmentsinassociationtoclinicalcognitivemoodandfatiguefeaturesinmultiplesclerosisastudyprotocol AT dimitriostsiptsios socialcognitionimpairmentsinassociationtoclinicalcognitivemoodandfatiguefeaturesinmultiplesclerosisastudyprotocol AT georgedvavougios socialcognitionimpairmentsinassociationtoclinicalcognitivemoodandfatiguefeaturesinmultiplesclerosisastudyprotocol AT annatsiakiri socialcognitionimpairmentsinassociationtoclinicalcognitivemoodandfatiguefeaturesinmultiplesclerosisastudyprotocol AT theofanisvorvolakos socialcognitionimpairmentsinassociationtoclinicalcognitivemoodandfatiguefeaturesinmultiplesclerosisastudyprotocol AT christoskokkotis socialcognitionimpairmentsinassociationtoclinicalcognitivemoodandfatiguefeaturesinmultiplesclerosisastudyprotocol AT ioannisiliopoulos socialcognitionimpairmentsinassociationtoclinicalcognitivemoodandfatiguefeaturesinmultiplesclerosisastudyprotocol AT nikolaosaggelousis socialcognitionimpairmentsinassociationtoclinicalcognitivemoodandfatiguefeaturesinmultiplesclerosisastudyprotocol AT konstantinosvadikolias socialcognitionimpairmentsinassociationtoclinicalcognitivemoodandfatiguefeaturesinmultiplesclerosisastudyprotocol |