18F-FDG-PET/CT can be used to predict distant metastasis in hypopharyngeal squamous cell carcinoma
Abstract Background Hypopharyngeal squamous cell carcinoma (HPSCC) has a high rate of distant metastasis, resulting in poor prognosis. The role of the maximum standardized uptake value (SUVmax), which was assessed via pretreatment 18-fluorodeoxyglucose positron emission tomography (FDG-PET), and com...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40463-022-00568-8 |
| _version_ | 1797970487307927552 |
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| author | Shinsuke Suzuki Satoshi Toyoma Tomoe Abe Tentaro Endo Teppei Kouga Yohei Kaswasaki Takechiyo Yamada |
| author_facet | Shinsuke Suzuki Satoshi Toyoma Tomoe Abe Tentaro Endo Teppei Kouga Yohei Kaswasaki Takechiyo Yamada |
| author_sort | Shinsuke Suzuki |
| collection | DOAJ |
| description | Abstract Background Hypopharyngeal squamous cell carcinoma (HPSCC) has a high rate of distant metastasis, resulting in poor prognosis. The role of the maximum standardized uptake value (SUVmax), which was assessed via pretreatment 18-fluorodeoxyglucose positron emission tomography (FDG-PET), and computed tomography (CT) was examined, for predicting distant metastasis and survival. Methods This study included 121 patients who underwent pretreatment FDG-PET/CT scanning and subsequent treatment for HPSCC. The SUVmax was measured via FDG-PET/CT. A receiver operating characteristic (ROC) curve analysis was used to determine whether the SUVmax was a predictor of distant metastasis and to select the best cutoff value. Univariate and multivariate Cox hazard regression analyses were used in identifying associations between the SUVmax and other clinicopathological factors with distant metastasis-free survival. Results Distant metastases were identified in 33 patients during the median follow-up of 24 months after treatment. The ROC curve analysis determined that SUVmax was predictive of distant metastasis and identified a SUVmax of 13.9 as the best potential cutoff value. The univariate analysis showed that T and N classification, clinical stage, and SUVmax were significantly related to distant metastasis. However, in multivariate analysis, an SUVmax ≥ 13.9 was the only independent predictor of distant metastasis. Patients with high SUVmax values displayed significantly shorter distant metastasis-free survival and overall survival. Conclusions SUVmax determined via pretreatment FDG-PET/CT is useful for predicting distant metastasis, distant metastasis-free survival, and overall survival in patients with HPSCC. Graphical Abstract |
| first_indexed | 2024-04-11T03:18:39Z |
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| id | doaj.art-bca5cbf831a04fc8a3094ca16bc53d10 |
| institution | Directory Open Access Journal |
| issn | 1916-0216 |
| language | English |
| last_indexed | 2024-04-11T03:18:39Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj.art-bca5cbf831a04fc8a3094ca16bc53d102023-01-02T09:41:45ZengBMCJournal of Otolaryngology - Head and Neck Surgery1916-02162022-04-015111810.1186/s40463-022-00568-818F-FDG-PET/CT can be used to predict distant metastasis in hypopharyngeal squamous cell carcinomaShinsuke Suzuki0Satoshi Toyoma1Tomoe Abe2Tentaro Endo3Teppei Kouga4Yohei Kaswasaki5Takechiyo Yamada6Department of Otorhinolaryngology and Head and Neck Surgery, Akita University Graduate School of MedicineDepartment of Otorhinolaryngology and Head and Neck Surgery, Akita University Graduate School of MedicineDepartment of Otorhinolaryngology and Head and Neck Surgery, Akita University Graduate School of MedicineDepartment of Otorhinolaryngology and Head and Neck Surgery, Akita University Graduate School of MedicineDepartment of Otorhinolaryngology and Head and Neck Surgery, Akita University Graduate School of MedicineDepartment of Otorhinolaryngology and Head and Neck Surgery, Akita University Graduate School of MedicineDepartment of Otorhinolaryngology and Head and Neck Surgery, Akita University Graduate School of MedicineAbstract Background Hypopharyngeal squamous cell carcinoma (HPSCC) has a high rate of distant metastasis, resulting in poor prognosis. The role of the maximum standardized uptake value (SUVmax), which was assessed via pretreatment 18-fluorodeoxyglucose positron emission tomography (FDG-PET), and computed tomography (CT) was examined, for predicting distant metastasis and survival. Methods This study included 121 patients who underwent pretreatment FDG-PET/CT scanning and subsequent treatment for HPSCC. The SUVmax was measured via FDG-PET/CT. A receiver operating characteristic (ROC) curve analysis was used to determine whether the SUVmax was a predictor of distant metastasis and to select the best cutoff value. Univariate and multivariate Cox hazard regression analyses were used in identifying associations between the SUVmax and other clinicopathological factors with distant metastasis-free survival. Results Distant metastases were identified in 33 patients during the median follow-up of 24 months after treatment. The ROC curve analysis determined that SUVmax was predictive of distant metastasis and identified a SUVmax of 13.9 as the best potential cutoff value. The univariate analysis showed that T and N classification, clinical stage, and SUVmax were significantly related to distant metastasis. However, in multivariate analysis, an SUVmax ≥ 13.9 was the only independent predictor of distant metastasis. Patients with high SUVmax values displayed significantly shorter distant metastasis-free survival and overall survival. Conclusions SUVmax determined via pretreatment FDG-PET/CT is useful for predicting distant metastasis, distant metastasis-free survival, and overall survival in patients with HPSCC. Graphical Abstracthttps://doi.org/10.1186/s40463-022-00568-8Hypopharyngeal squamous cell carcinomaDistant metastasis18F-FDG-PET/CTMaximum standardized uptake valueSurvival |
| spellingShingle | Shinsuke Suzuki Satoshi Toyoma Tomoe Abe Tentaro Endo Teppei Kouga Yohei Kaswasaki Takechiyo Yamada 18F-FDG-PET/CT can be used to predict distant metastasis in hypopharyngeal squamous cell carcinoma Journal of Otolaryngology - Head and Neck Surgery Hypopharyngeal squamous cell carcinoma Distant metastasis 18F-FDG-PET/CT Maximum standardized uptake value Survival |
| title | 18F-FDG-PET/CT can be used to predict distant metastasis in hypopharyngeal squamous cell carcinoma |
| title_full | 18F-FDG-PET/CT can be used to predict distant metastasis in hypopharyngeal squamous cell carcinoma |
| title_fullStr | 18F-FDG-PET/CT can be used to predict distant metastasis in hypopharyngeal squamous cell carcinoma |
| title_full_unstemmed | 18F-FDG-PET/CT can be used to predict distant metastasis in hypopharyngeal squamous cell carcinoma |
| title_short | 18F-FDG-PET/CT can be used to predict distant metastasis in hypopharyngeal squamous cell carcinoma |
| title_sort | 18f fdg pet ct can be used to predict distant metastasis in hypopharyngeal squamous cell carcinoma |
| topic | Hypopharyngeal squamous cell carcinoma Distant metastasis 18F-FDG-PET/CT Maximum standardized uptake value Survival |
| url | https://doi.org/10.1186/s40463-022-00568-8 |
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