Brain-derived neurotrophic factor in patients with advanced age-related macular degeneration
<b>AIM:</b> To investigate the serum level of the brain-derived neurotrophic factor (BDNF) in age-related macular degeneration (AMD) and healthy control subjects. The disruption in the tight balance of neuroinflammatory and neuroprotective processes in an immune-privileged site like reti...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2015-10-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.cn/en_publish/2015/5/20150525.pdf |
| _version_ | 1811203570171641856 |
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| author | Mehrdad Afarid Mohammad Torabi-Nami Alijan Nemati Amir Khosravi Mahyar Malekzadeh |
| author_facet | Mehrdad Afarid Mohammad Torabi-Nami Alijan Nemati Amir Khosravi Mahyar Malekzadeh |
| author_sort | Mehrdad Afarid |
| collection | DOAJ |
| description | <b>AIM:</b> To investigate the serum level of the brain-derived neurotrophic factor (BDNF) in age-related macular degeneration (AMD) and healthy control subjects. The disruption in the tight balance of neuroinflammatory and neuroprotective processes in an immune-privileged site like retina is proposed to contribute to the pathogenesis of AMD. One of the main neuroprotective mediators in the central nervous system is BDNF with its serum level notably affected in several neurodegenerative disorders.<b>METHODS</b>:Thirty-six patients with AMD and 36 age-matched controls were enrolled in this study. The serum level of BDNF was measured using the enzyme-linked immunosorbent assay method. Results were analyzed to compare case and control values. Comparisons were also made between the BDNF level of wet- <i>vs</i> dry-AMD, and male <i>vs</i> female patients and controls. Analysis of variance (ANOVA) and Student’s<i> t</i>-test were employed to analyze the data.<b>RESULTS:</b> The mean BDNF levels in AMD group were significantly higher than the control group. Furthermore, our analysis revealed greater BDNF values in all AMD subgroups compared to controls (<i>P</i>=0.004, 0.005, 0.001 and 0.02 for male wet-AMD, male dry-AMD, female wet-AMD and female dry-AMD <i>vs</i> controls, respectively). The BDNF level however did not vary between wet- and dry-AMD patients (<i>P</i>=0.74). While within-group comparisons in males and females of AMD and control groups did not show any difference in BDNF (<i>P</i>=0.16, 0.64 and 0.85 for wet-AMD, dry-AMD and control groups, respectively), between-group data showed a higher mean BDNF in both male and female AMD subjects than their peer controls.<b>CONCLUSION:</b> This study demonstrated that the serum BDNF level is different in patients with AMD as compared to subjects without AMD. Future attempts should be done to unravel beneficial or deleterious effect of this neurotrophin in the pathogenesis of AMD. |
| first_indexed | 2024-04-12T02:57:34Z |
| format | Article |
| id | doaj.art-bcaa45c96e984dd1aa7ee26e9c5c18d7 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-12T02:57:34Z |
| publishDate | 2015-10-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-bcaa45c96e984dd1aa7ee26e9c5c18d72022-12-22T03:50:45ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982015-10-018599199510.3980/j.issn.2222-3959.2015.05.25Brain-derived neurotrophic factor in patients with advanced age-related macular degenerationMehrdad Afarid0Mohammad Torabi-Nami1Alijan Nemati2Amir Khosravi3Mahyar Malekzadeh4Department of Ophthalmology, Poostchi Eye Research Center, School of Medicine , Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran<br>Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran<br>Poostchi Eye Research Center, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran<br>Student Research Committee, Shiraz University of Medical Sciences and Poostchi Eye Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran<br>Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran<b>AIM:</b> To investigate the serum level of the brain-derived neurotrophic factor (BDNF) in age-related macular degeneration (AMD) and healthy control subjects. The disruption in the tight balance of neuroinflammatory and neuroprotective processes in an immune-privileged site like retina is proposed to contribute to the pathogenesis of AMD. One of the main neuroprotective mediators in the central nervous system is BDNF with its serum level notably affected in several neurodegenerative disorders.<b>METHODS</b>:Thirty-six patients with AMD and 36 age-matched controls were enrolled in this study. The serum level of BDNF was measured using the enzyme-linked immunosorbent assay method. Results were analyzed to compare case and control values. Comparisons were also made between the BDNF level of wet- <i>vs</i> dry-AMD, and male <i>vs</i> female patients and controls. Analysis of variance (ANOVA) and Student’s<i> t</i>-test were employed to analyze the data.<b>RESULTS:</b> The mean BDNF levels in AMD group were significantly higher than the control group. Furthermore, our analysis revealed greater BDNF values in all AMD subgroups compared to controls (<i>P</i>=0.004, 0.005, 0.001 and 0.02 for male wet-AMD, male dry-AMD, female wet-AMD and female dry-AMD <i>vs</i> controls, respectively). The BDNF level however did not vary between wet- and dry-AMD patients (<i>P</i>=0.74). While within-group comparisons in males and females of AMD and control groups did not show any difference in BDNF (<i>P</i>=0.16, 0.64 and 0.85 for wet-AMD, dry-AMD and control groups, respectively), between-group data showed a higher mean BDNF in both male and female AMD subjects than their peer controls.<b>CONCLUSION:</b> This study demonstrated that the serum BDNF level is different in patients with AMD as compared to subjects without AMD. Future attempts should be done to unravel beneficial or deleterious effect of this neurotrophin in the pathogenesis of AMD.http://www.ijo.cn/en_publish/2015/5/20150525.pdfage-related macular degenerationbrain-derived neurotrophic factorserum levelpathogenesis |
| spellingShingle | Mehrdad Afarid Mohammad Torabi-Nami Alijan Nemati Amir Khosravi Mahyar Malekzadeh Brain-derived neurotrophic factor in patients with advanced age-related macular degeneration International Journal of Ophthalmology age-related macular degeneration brain-derived neurotrophic factor serum level pathogenesis |
| title | Brain-derived neurotrophic factor in patients with advanced age-related macular degeneration |
| title_full | Brain-derived neurotrophic factor in patients with advanced age-related macular degeneration |
| title_fullStr | Brain-derived neurotrophic factor in patients with advanced age-related macular degeneration |
| title_full_unstemmed | Brain-derived neurotrophic factor in patients with advanced age-related macular degeneration |
| title_short | Brain-derived neurotrophic factor in patients with advanced age-related macular degeneration |
| title_sort | brain derived neurotrophic factor in patients with advanced age related macular degeneration |
| topic | age-related macular degeneration brain-derived neurotrophic factor serum level pathogenesis |
| url | http://www.ijo.cn/en_publish/2015/5/20150525.pdf |
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