Glycemic Control Potential of Chemically Characterized Extract from <i>Withania frutescens</i> L. Roots in Severe Diabetes-Induced Mice
Diabetes mellitus is a metabolic syndrome that causes impairment, mortality, and many other complications. Insulin and several synthetic medications are currently used in the treatment of diabetes. However, these pharmaceutical drugs are costly, and therefore medicines place priority on alternatives...
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MDPI AG
2021-04-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/9/3998 |
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| author | Abdelfattah El Moussaoui Hamza Mechchate Mohammed Bourhia Imane Es-safi Ahmad Mohammad Salamatullah Mohammed Saeed Alkaltham Heba Khalil Alyahya Dalila Bousta Amina Bari |
| author_facet | Abdelfattah El Moussaoui Hamza Mechchate Mohammed Bourhia Imane Es-safi Ahmad Mohammad Salamatullah Mohammed Saeed Alkaltham Heba Khalil Alyahya Dalila Bousta Amina Bari |
| author_sort | Abdelfattah El Moussaoui |
| collection | DOAJ |
| description | Diabetes mellitus is a metabolic syndrome that causes impairment, mortality, and many other complications. Insulin and several synthetic medications are currently used in the treatment of diabetes. However, these pharmaceutical drugs are costly, and therefore medicines place priority on alternatives to fight this lethal disease. This modest study aims to investigate the chemical composition, antidiabetic and antihyperglycemic potentials along with subacute toxicity (bodyweight change and biochemical parameters) of hydroethanol extract from <i>Withania frutescens</i> L. roots (WFRE). The chemical analysis was carried out using GC–MS after extract silylation. The chemical analysis identified many potentially active compounds that may determine the antidiabetic results of WFRE. The antidiabetic effect of WFRE was evaluated in mice with severe diabetes using oral administration of doses up to 400 mg/kg for 28 days. The results of the antidiabetic and antihyperglycemic tests indicate that WFRE possesses promising glucose-lowering effects and, as a result, it may serve as an antidiabetic alternative for long-term use. The 4-week treatments with different doses of plant extract did not alter the bodyweight appearance of the diabetic mice nor their biochemical parameters (AST and ALT). The findings obtained indicate that the studied plant extract controlled severe diabetes in mice. Therefore, <i>Withania frutescens</i> L. can serve society as it provides natural agents to control diabetes. |
| first_indexed | 2024-03-10T11:53:22Z |
| format | Article |
| id | doaj.art-bcab41c0fbb44ddab232f125795b1024 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T11:53:22Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-bcab41c0fbb44ddab232f125795b10242023-11-21T17:32:25ZengMDPI AGApplied Sciences2076-34172021-04-01119399810.3390/app11093998Glycemic Control Potential of Chemically Characterized Extract from <i>Withania frutescens</i> L. Roots in Severe Diabetes-Induced MiceAbdelfattah El Moussaoui0Hamza Mechchate1Mohammed Bourhia2Imane Es-safi3Ahmad Mohammad Salamatullah4Mohammed Saeed Alkaltham5Heba Khalil Alyahya6Dalila Bousta7Amina Bari8Laboratory of Biotechnology, Environment, Agrifood, and Health, Faculté of science-Fez, University of Sidi Mohamed Ben Abdellah, Fez 30050, MoroccoLaboratory of Biotechnology, Environment, Agrifood, and Health, Faculté of science-Fez, University of Sidi Mohamed Ben Abdellah, Fez 30050, MoroccoLaboratory of Chemistry, Biochemistry, Nutrition, and Environment, Faculty of Medicine and Pharmacy, University Hassan II, Casablanca 20000, MoroccoLaboratory of Biotechnology, Environment, Agrifood, and Health, Faculté of science-Fez, University of Sidi Mohamed Ben Abdellah, Fez 30050, MoroccoDepartment of Food Science & Nutrition, College of Food and Agricultural Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi ArabiaDepartment of Food Science & Nutrition, College of Food and Agricultural Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi ArabiaDepartment of Food Science & Nutrition, College of Food and Agricultural Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi ArabiaLaboratory of Biotechnology, Environment, Agrifood, and Health, Faculté of science-Fez, University of Sidi Mohamed Ben Abdellah, Fez 30050, MoroccoLaboratory of Biotechnology, Environment, Agrifood, and Health, Faculté of science-Fez, University of Sidi Mohamed Ben Abdellah, Fez 30050, MoroccoDiabetes mellitus is a metabolic syndrome that causes impairment, mortality, and many other complications. Insulin and several synthetic medications are currently used in the treatment of diabetes. However, these pharmaceutical drugs are costly, and therefore medicines place priority on alternatives to fight this lethal disease. This modest study aims to investigate the chemical composition, antidiabetic and antihyperglycemic potentials along with subacute toxicity (bodyweight change and biochemical parameters) of hydroethanol extract from <i>Withania frutescens</i> L. roots (WFRE). The chemical analysis was carried out using GC–MS after extract silylation. The chemical analysis identified many potentially active compounds that may determine the antidiabetic results of WFRE. The antidiabetic effect of WFRE was evaluated in mice with severe diabetes using oral administration of doses up to 400 mg/kg for 28 days. The results of the antidiabetic and antihyperglycemic tests indicate that WFRE possesses promising glucose-lowering effects and, as a result, it may serve as an antidiabetic alternative for long-term use. The 4-week treatments with different doses of plant extract did not alter the bodyweight appearance of the diabetic mice nor their biochemical parameters (AST and ALT). The findings obtained indicate that the studied plant extract controlled severe diabetes in mice. Therefore, <i>Withania frutescens</i> L. can serve society as it provides natural agents to control diabetes.https://www.mdpi.com/2076-3417/11/9/3998<i>Withania frutescens</i> L.rootsdiabetes mellitusglibenclamideantidiabeticantihyperglycemic |
| spellingShingle | Abdelfattah El Moussaoui Hamza Mechchate Mohammed Bourhia Imane Es-safi Ahmad Mohammad Salamatullah Mohammed Saeed Alkaltham Heba Khalil Alyahya Dalila Bousta Amina Bari Glycemic Control Potential of Chemically Characterized Extract from <i>Withania frutescens</i> L. Roots in Severe Diabetes-Induced Mice Applied Sciences <i>Withania frutescens</i> L. roots diabetes mellitus glibenclamide antidiabetic antihyperglycemic |
| title | Glycemic Control Potential of Chemically Characterized Extract from <i>Withania frutescens</i> L. Roots in Severe Diabetes-Induced Mice |
| title_full | Glycemic Control Potential of Chemically Characterized Extract from <i>Withania frutescens</i> L. Roots in Severe Diabetes-Induced Mice |
| title_fullStr | Glycemic Control Potential of Chemically Characterized Extract from <i>Withania frutescens</i> L. Roots in Severe Diabetes-Induced Mice |
| title_full_unstemmed | Glycemic Control Potential of Chemically Characterized Extract from <i>Withania frutescens</i> L. Roots in Severe Diabetes-Induced Mice |
| title_short | Glycemic Control Potential of Chemically Characterized Extract from <i>Withania frutescens</i> L. Roots in Severe Diabetes-Induced Mice |
| title_sort | glycemic control potential of chemically characterized extract from i withania frutescens i l roots in severe diabetes induced mice |
| topic | <i>Withania frutescens</i> L. roots diabetes mellitus glibenclamide antidiabetic antihyperglycemic |
| url | https://www.mdpi.com/2076-3417/11/9/3998 |
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