Combination of shikonin with paclitaxel overcomes multidrug resistance in human ovarian carcinoma cells in a P-gp-independent manner through enhanced ROS generation

Combination of shikonin with paclitaxel overcomes multidrug resistance in human ovarian carcinoma cells in a P-gp-independent manner through enhanced ROS generation

Abstract Background Shikonin (SKN), a naphthoquinone compound, is isolated from Chinese herbal medicine Lithospermum root and has been studied as an anticancer drug candidate in human tumor models. This study is designed to investigate whether SKN can sensitize the therapeutic effect of paclitaxel (...

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Bibliographic Details
Main Authors: Zhu Wang, Jianhua Yin, Mingxing Li, Jing Shen, Zhangang Xiao, Yueshui Zhao, Chengliang Huang, Hanyu Zhang, Zhuo Zhang, Chi Hin Cho, Xu Wu
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Chinese Medicine
Subjects:
Shikonin
Paclitaxel
Multidrug resistance
Reactive oxygen species
Pyruvate kinase M2
P-glycoprotein
Online Access:http://link.springer.com/article/10.1186/s13020-019-0231-3

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