CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients
You-ting Lin,1 Xue Yang,2 Jing-wei Lv,2 Xue-wu Liu,2,* Sheng-jun Wang2,* 1Department of Neurology, Shandong Provincial Hospital, Shandong University, Ji’nan, People’s Republic of China; 2Department of Neurology, Qilu Hospital, Shandong University, Ji’nan, People&rsq...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-10-01
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| Series: | Neuropsychiatric Disease and Treatment |
| Subjects: | |
| Online Access: | https://www.dovepress.com/cxcl13-is-a-biomarker-of-anti-leucine-rich-glioma-inactivated-protein--peer-reviewed-article-NDT |
| _version_ | 1818853624746344448 |
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| author | Lin Y Yang X Lv J Liu X Wang S |
| author_facet | Lin Y Yang X Lv J Liu X Wang S |
| author_sort | Lin Y |
| collection | DOAJ |
| description | You-ting Lin,1 Xue Yang,2 Jing-wei Lv,2 Xue-wu Liu,2,* Sheng-jun Wang2,* 1Department of Neurology, Shandong Provincial Hospital, Shandong University, Ji’nan, People’s Republic of China; 2Department of Neurology, Qilu Hospital, Shandong University, Ji’nan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Sheng-jun Wang;Xue-wu LiuDepartment of Neurology, Qilu Hospital, Shandong University, 107# Wen Hua Xi Road, Ji’nan 250012, Peoples Republic of ChinaEmail junwang9999@sina.com; qiluliuym66@163.comBackground: Although antibody-mediated immune responses are considered pathogenic and responsible for neural injury in anti-leucine-rich glioma-inactivated protein 1 (anti-LGI1) encephalitis, previous studies have indicated that cytokines and chemokines might play roles in the pathogenic process by serving as B cell enhancers. In this study, we detected the profiles of cytokines and chemokines in the cerebral fluid (CSF) and serum of patients with anti-LGI1 encephalitis to identify potential biomarkers.Methods: Sixteen patients diagnosed with anti-LGI1 encephalitis and nine patients diagnosed with noninflammatory neurologic disorders were included in the study. Cytokines and chemokines including IL-6, IL-10, IL-17, CXCL12, CXCL13, BAFF and HMGB1 in serum and CSF were measured.Results: The serum and CSF levels of CXCL13 were significantly higher in patients with anti-LGI1 encephalitis (36.32±34.71 pg/mL and 2.23±2.41 pg/mL, respectively) than in controls (10.84±5.02 pg/mL and 0.34±0.21 pg/mL, respectively). There was no significant difference in serum or CSF levels of IL-6, IL-10, IL-17, CXCL12, BAFF and HMGB1 between the two groups.Conclusion: CXCL13 is a potential biomarker of active inflammation in anti-LGI1 encephalitis. The distinctive response of cytokines and chemokines might be closely linked to the mechanisms underlying this condition.Keywords: leucine-rich glioma-inactivated protein 1, CXCL13, cytokine, encephalitis, biomarker |
| first_indexed | 2024-12-19T07:39:47Z |
| format | Article |
| id | doaj.art-bcad2b20d19e46ea957cd8118e8661f9 |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-12-19T07:39:47Z |
| publishDate | 2019-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-bcad2b20d19e46ea957cd8118e8661f92022-12-21T20:30:29ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212019-10-01Volume 152909291549065CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis PatientsLin YYang XLv JLiu XWang SYou-ting Lin,1 Xue Yang,2 Jing-wei Lv,2 Xue-wu Liu,2,* Sheng-jun Wang2,* 1Department of Neurology, Shandong Provincial Hospital, Shandong University, Ji’nan, People’s Republic of China; 2Department of Neurology, Qilu Hospital, Shandong University, Ji’nan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Sheng-jun Wang;Xue-wu LiuDepartment of Neurology, Qilu Hospital, Shandong University, 107# Wen Hua Xi Road, Ji’nan 250012, Peoples Republic of ChinaEmail junwang9999@sina.com; qiluliuym66@163.comBackground: Although antibody-mediated immune responses are considered pathogenic and responsible for neural injury in anti-leucine-rich glioma-inactivated protein 1 (anti-LGI1) encephalitis, previous studies have indicated that cytokines and chemokines might play roles in the pathogenic process by serving as B cell enhancers. In this study, we detected the profiles of cytokines and chemokines in the cerebral fluid (CSF) and serum of patients with anti-LGI1 encephalitis to identify potential biomarkers.Methods: Sixteen patients diagnosed with anti-LGI1 encephalitis and nine patients diagnosed with noninflammatory neurologic disorders were included in the study. Cytokines and chemokines including IL-6, IL-10, IL-17, CXCL12, CXCL13, BAFF and HMGB1 in serum and CSF were measured.Results: The serum and CSF levels of CXCL13 were significantly higher in patients with anti-LGI1 encephalitis (36.32±34.71 pg/mL and 2.23±2.41 pg/mL, respectively) than in controls (10.84±5.02 pg/mL and 0.34±0.21 pg/mL, respectively). There was no significant difference in serum or CSF levels of IL-6, IL-10, IL-17, CXCL12, BAFF and HMGB1 between the two groups.Conclusion: CXCL13 is a potential biomarker of active inflammation in anti-LGI1 encephalitis. The distinctive response of cytokines and chemokines might be closely linked to the mechanisms underlying this condition.Keywords: leucine-rich glioma-inactivated protein 1, CXCL13, cytokine, encephalitis, biomarkerhttps://www.dovepress.com/cxcl13-is-a-biomarker-of-anti-leucine-rich-glioma-inactivated-protein--peer-reviewed-article-NDTleucine-rich glioma-inactivated protein 1CXCL13cytokineencephalitisbiomarker |
| spellingShingle | Lin Y Yang X Lv J Liu X Wang S CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients Neuropsychiatric Disease and Treatment leucine-rich glioma-inactivated protein 1 CXCL13 cytokine encephalitis biomarker |
| title | CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients |
| title_full | CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients |
| title_fullStr | CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients |
| title_full_unstemmed | CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients |
| title_short | CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients |
| title_sort | cxcl13 is a biomarker of anti leucine rich glioma inactivated protein 1 encephalitis patients |
| topic | leucine-rich glioma-inactivated protein 1 CXCL13 cytokine encephalitis biomarker |
| url | https://www.dovepress.com/cxcl13-is-a-biomarker-of-anti-leucine-rich-glioma-inactivated-protein--peer-reviewed-article-NDT |
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