Association between new-onset liver cirrhosis and suicide risk in South Korea: A nationwide cohort study
Background/Aims Current evidence suggests that liver cirrhosis (LC) causes severe psychological stress and depression, which are risk factors for suicide. Although previous studies reported the association between LC and suicidal thoughts, little is known of its effect on suicidal deaths. Therefore,...
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of the Liver
2021-04-01
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| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-2020-0227.pdf |
| _version_ | 1818730166209216512 |
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| author | Suk-Yong Jang Woo Sun Rou Seok Hyun Kim Byung Seok Lee Hyuk Soo Eun |
| author_facet | Suk-Yong Jang Woo Sun Rou Seok Hyun Kim Byung Seok Lee Hyuk Soo Eun |
| author_sort | Suk-Yong Jang |
| collection | DOAJ |
| description | Background/Aims Current evidence suggests that liver cirrhosis (LC) causes severe psychological stress and depression, which are risk factors for suicide. Although previous studies reported the association between LC and suicidal thoughts, little is known of its effect on suicidal deaths. Therefore, this study was undertaken to investigate the effect of new-onset LC on suicide. Methods From the National Health Insurance Service-National Sample Cohort of South Korea, 5,809 incident LC patients and 11,618 risk-set controls matched by propensity score were selected for follow-up. The incidence rate of suicide was estimated using a generalized estimating equation with a Poisson distribution. Effect size was presented as a hazard ratio (HR) using Cox’s proportional hazards model. Results The incidence rate of suicide was 143.3 cases per 100,000 person years (95% confidence interval [CI], 100.2–205.1) among the LC cohort. The LC patients were 2.37 times more likely to commit suicide compared with matched controls (HR, 2.37; 95% CI, 1.44–3.88). Increased suicide risk was evident within the first 2 years of the follow-up period (HR, 2.59; 95% CI, 1.20–5.60) and among the 18–49-year-old age group (HR, 3.72; 95% CI, 1.45–9.56). Conclusions Our study found increased risk of suicide in patients with new onset LC, especially during the early period following diagnosis and in younger patients. To decrease this suicide risk, a regular and continuous social support system is required. |
| first_indexed | 2024-12-17T22:57:27Z |
| format | Article |
| id | doaj.art-bcadfc7f1c03440781139d6c83e31b07 |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-12-17T22:57:27Z |
| publishDate | 2021-04-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-bcadfc7f1c03440781139d6c83e31b072022-12-21T21:29:31ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2021-04-0127228329410.3350/cmh.2020.02271582Association between new-onset liver cirrhosis and suicide risk in South Korea: A nationwide cohort studySuk-Yong Jang0Woo Sun Rou1Seok Hyun Kim2Byung Seok Lee3Hyuk Soo Eun4 Department of Preventive Medicine, Eulji University College of Medicine, Daejeon, Korea Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, KoreaBackground/Aims Current evidence suggests that liver cirrhosis (LC) causes severe psychological stress and depression, which are risk factors for suicide. Although previous studies reported the association between LC and suicidal thoughts, little is known of its effect on suicidal deaths. Therefore, this study was undertaken to investigate the effect of new-onset LC on suicide. Methods From the National Health Insurance Service-National Sample Cohort of South Korea, 5,809 incident LC patients and 11,618 risk-set controls matched by propensity score were selected for follow-up. The incidence rate of suicide was estimated using a generalized estimating equation with a Poisson distribution. Effect size was presented as a hazard ratio (HR) using Cox’s proportional hazards model. Results The incidence rate of suicide was 143.3 cases per 100,000 person years (95% confidence interval [CI], 100.2–205.1) among the LC cohort. The LC patients were 2.37 times more likely to commit suicide compared with matched controls (HR, 2.37; 95% CI, 1.44–3.88). Increased suicide risk was evident within the first 2 years of the follow-up period (HR, 2.59; 95% CI, 1.20–5.60) and among the 18–49-year-old age group (HR, 3.72; 95% CI, 1.45–9.56). Conclusions Our study found increased risk of suicide in patients with new onset LC, especially during the early period following diagnosis and in younger patients. To decrease this suicide risk, a regular and continuous social support system is required.http://e-cmh.org/upload/pdf/cmh-2020-0227.pdfliver cirrhosissuicideriskdepressionpsychological distress |
| spellingShingle | Suk-Yong Jang Woo Sun Rou Seok Hyun Kim Byung Seok Lee Hyuk Soo Eun Association between new-onset liver cirrhosis and suicide risk in South Korea: A nationwide cohort study Clinical and Molecular Hepatology liver cirrhosis suicide risk depression psychological distress |
| title | Association between new-onset liver cirrhosis and suicide risk in South Korea: A nationwide cohort study |
| title_full | Association between new-onset liver cirrhosis and suicide risk in South Korea: A nationwide cohort study |
| title_fullStr | Association between new-onset liver cirrhosis and suicide risk in South Korea: A nationwide cohort study |
| title_full_unstemmed | Association between new-onset liver cirrhosis and suicide risk in South Korea: A nationwide cohort study |
| title_short | Association between new-onset liver cirrhosis and suicide risk in South Korea: A nationwide cohort study |
| title_sort | association between new onset liver cirrhosis and suicide risk in south korea a nationwide cohort study |
| topic | liver cirrhosis suicide risk depression psychological distress |
| url | http://e-cmh.org/upload/pdf/cmh-2020-0227.pdf |
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