Environmental deformations dynamically shift the grid cell spatial metric
In familiar environments, the firing fields of entorhinal grid cells form regular triangular lattices. However, when the geometric shape of the environment is deformed, these time-averaged grid patterns are distorted in a grid scale-dependent and local manner. We hypothesized that this distortion in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-10-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/38169 |
| _version_ | 1811202729949790208 |
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| author | Alexandra T Keinath Russell A Epstein Vijay Balasubramanian |
| author_facet | Alexandra T Keinath Russell A Epstein Vijay Balasubramanian |
| author_sort | Alexandra T Keinath |
| collection | DOAJ |
| description | In familiar environments, the firing fields of entorhinal grid cells form regular triangular lattices. However, when the geometric shape of the environment is deformed, these time-averaged grid patterns are distorted in a grid scale-dependent and local manner. We hypothesized that this distortion in part reflects dynamic anchoring of the grid code to displaced boundaries, possibly through border cell-grid cell interactions. To test this hypothesis, we first reanalyzed two existing rodent grid rescaling datasets to identify previously unrecognized boundary-tethered shifts in grid phase that contribute to the appearance of rescaling. We then demonstrated in a computational model that boundary-tethered phase shifts, as well as scale-dependent and local distortions of the time-averaged grid pattern, could emerge from border-grid interactions without altering inherent grid scale. Together, these results demonstrate that environmental deformations induce history-dependent shifts in grid phase, and implicate border-grid interactions as a potential mechanism underlying these dynamics. |
| first_indexed | 2024-04-12T02:43:22Z |
| format | Article |
| id | doaj.art-bcb05beb4bf24d3b83aa8a659af1aaec |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:43:22Z |
| publishDate | 2018-10-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-bcb05beb4bf24d3b83aa8a659af1aaec2022-12-22T03:51:15ZengeLife Sciences Publications LtdeLife2050-084X2018-10-01710.7554/eLife.38169Environmental deformations dynamically shift the grid cell spatial metricAlexandra T Keinath0https://orcid.org/0000-0003-1622-7835Russell A Epstein1Vijay Balasubramanian2https://orcid.org/0000-0002-6497-3819Department of Psychology, University of Pennsylvania, Pennsylvania, United StatesDepartment of Psychology, University of Pennsylvania, Pennsylvania, United StatesDepartment of Physics, University of Pennsylvania, Pennsylvania, United StatesIn familiar environments, the firing fields of entorhinal grid cells form regular triangular lattices. However, when the geometric shape of the environment is deformed, these time-averaged grid patterns are distorted in a grid scale-dependent and local manner. We hypothesized that this distortion in part reflects dynamic anchoring of the grid code to displaced boundaries, possibly through border cell-grid cell interactions. To test this hypothesis, we first reanalyzed two existing rodent grid rescaling datasets to identify previously unrecognized boundary-tethered shifts in grid phase that contribute to the appearance of rescaling. We then demonstrated in a computational model that boundary-tethered phase shifts, as well as scale-dependent and local distortions of the time-averaged grid pattern, could emerge from border-grid interactions without altering inherent grid scale. Together, these results demonstrate that environmental deformations induce history-dependent shifts in grid phase, and implicate border-grid interactions as a potential mechanism underlying these dynamics.https://elifesciences.org/articles/38169grid cellplace cellhippocampusentorhinal cortexcomputational modeldeformation |
| spellingShingle | Alexandra T Keinath Russell A Epstein Vijay Balasubramanian Environmental deformations dynamically shift the grid cell spatial metric eLife grid cell place cell hippocampus entorhinal cortex computational model deformation |
| title | Environmental deformations dynamically shift the grid cell spatial metric |
| title_full | Environmental deformations dynamically shift the grid cell spatial metric |
| title_fullStr | Environmental deformations dynamically shift the grid cell spatial metric |
| title_full_unstemmed | Environmental deformations dynamically shift the grid cell spatial metric |
| title_short | Environmental deformations dynamically shift the grid cell spatial metric |
| title_sort | environmental deformations dynamically shift the grid cell spatial metric |
| topic | grid cell place cell hippocampus entorhinal cortex computational model deformation |
| url | https://elifesciences.org/articles/38169 |
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