Influence of light–dark cycle on delayed recovery from isoflurane anesthesia induced by hypnotics in mice
We previously reported that brotizolam, but not suvorexant, delayed recovery from isoflurane anesthesia in mice. However, the effects of hypnotics may be altered by the circadian rhythm. Locomotor activity was measured using sighted (ICR and C57BL/6J) and blind (FVB/N and C3H/HeN) mice, and the effe...
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Elsevier
2021-04-01
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| Series: | Journal of Pharmacological Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861321000141 |
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| author | Atsunobu Sugano Hiroki Murai Syunpei Horiguchi Yuma Yoshimoto Yuki Amano Tomoki Kimura Yoshinori Iba |
| author_facet | Atsunobu Sugano Hiroki Murai Syunpei Horiguchi Yuma Yoshimoto Yuki Amano Tomoki Kimura Yoshinori Iba |
| author_sort | Atsunobu Sugano |
| collection | DOAJ |
| description | We previously reported that brotizolam, but not suvorexant, delayed recovery from isoflurane anesthesia in mice. However, the effects of hypnotics may be altered by the circadian rhythm. Locomotor activity was measured using sighted (ICR and C57BL/6J) and blind (FVB/N and C3H/HeN) mice, and the effects of hypnotics on isoflurane anesthesia were compared during the light and dark periods. In sighted mice, recovery induced by brotizolam was delayed in the light period, while that by suvorexant was delayed in the dark period. In C57BL/6J mice, delayed recovery induced by brotizolam was marked, and that by suvorexant was observed in the light and dark periods. Locomotor activity was low in the last 6 h of the dark period in blind mice, and was similar to that in the light period. In blind mice, delayed recovery induced by brotizolam was identical in both periods, while suvorexant did not influence recovery from isoflurane anesthesia. These results suggest that the effects of hypnotics on isoflurane anesthesia are altered by the circadian rhythm and that daily light–dark stimuli may be required for the chronopharmacological effects of hypnotics. |
| first_indexed | 2024-12-13T17:40:28Z |
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| id | doaj.art-bcb118005615424c83a501481444bfea |
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| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-13T17:40:28Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
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| spelling | doaj.art-bcb118005615424c83a501481444bfea2022-12-21T23:36:46ZengElsevierJournal of Pharmacological Sciences1347-86132021-04-011454335339Influence of light–dark cycle on delayed recovery from isoflurane anesthesia induced by hypnotics in miceAtsunobu Sugano0Hiroki Murai1Syunpei Horiguchi2Yuma Yoshimoto3Yuki Amano4Tomoki Kimura5Yoshinori Iba6Department of Life Science, Faculty of Science and Engineering, Setsunan University, Neyagawa, Osaka, JapanDepartment of Life Science, Faculty of Science and Engineering, Setsunan University, Neyagawa, Osaka, JapanDepartment of Life Science, Faculty of Science and Engineering, Setsunan University, Neyagawa, Osaka, JapanDepartment of Life Science, Faculty of Science and Engineering, Setsunan University, Neyagawa, Osaka, JapanDepartment of Life Science, Faculty of Science and Engineering, Setsunan University, Neyagawa, Osaka, JapanDepartment of Life Science, Faculty of Science and Engineering, Setsunan University, Neyagawa, Osaka, JapanCorresponding author.; Department of Life Science, Faculty of Science and Engineering, Setsunan University, Neyagawa, Osaka, JapanWe previously reported that brotizolam, but not suvorexant, delayed recovery from isoflurane anesthesia in mice. However, the effects of hypnotics may be altered by the circadian rhythm. Locomotor activity was measured using sighted (ICR and C57BL/6J) and blind (FVB/N and C3H/HeN) mice, and the effects of hypnotics on isoflurane anesthesia were compared during the light and dark periods. In sighted mice, recovery induced by brotizolam was delayed in the light period, while that by suvorexant was delayed in the dark period. In C57BL/6J mice, delayed recovery induced by brotizolam was marked, and that by suvorexant was observed in the light and dark periods. Locomotor activity was low in the last 6 h of the dark period in blind mice, and was similar to that in the light period. In blind mice, delayed recovery induced by brotizolam was identical in both periods, while suvorexant did not influence recovery from isoflurane anesthesia. These results suggest that the effects of hypnotics on isoflurane anesthesia are altered by the circadian rhythm and that daily light–dark stimuli may be required for the chronopharmacological effects of hypnotics.http://www.sciencedirect.com/science/article/pii/S1347861321000141HypnoticsCircadian rhythmChronopharmacologyOrexinergic neuronsGABAergic neurons |
| spellingShingle | Atsunobu Sugano Hiroki Murai Syunpei Horiguchi Yuma Yoshimoto Yuki Amano Tomoki Kimura Yoshinori Iba Influence of light–dark cycle on delayed recovery from isoflurane anesthesia induced by hypnotics in mice Journal of Pharmacological Sciences Hypnotics Circadian rhythm Chronopharmacology Orexinergic neurons GABAergic neurons |
| title | Influence of light–dark cycle on delayed recovery from isoflurane anesthesia induced by hypnotics in mice |
| title_full | Influence of light–dark cycle on delayed recovery from isoflurane anesthesia induced by hypnotics in mice |
| title_fullStr | Influence of light–dark cycle on delayed recovery from isoflurane anesthesia induced by hypnotics in mice |
| title_full_unstemmed | Influence of light–dark cycle on delayed recovery from isoflurane anesthesia induced by hypnotics in mice |
| title_short | Influence of light–dark cycle on delayed recovery from isoflurane anesthesia induced by hypnotics in mice |
| title_sort | influence of light dark cycle on delayed recovery from isoflurane anesthesia induced by hypnotics in mice |
| topic | Hypnotics Circadian rhythm Chronopharmacology Orexinergic neurons GABAergic neurons |
| url | http://www.sciencedirect.com/science/article/pii/S1347861321000141 |
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