Site I Inactivation Impacts Calmodulin Calcium Binding and Activation of Bordetella pertussis Adenylate Cyclase Toxin

Site I Inactivation Impacts Calmodulin Calcium Binding and Activation of Bordetella pertussis Adenylate Cyclase Toxin

Site I inactivation of calmodulin (CaM) was used to examine the importance of aspartic acid 22 at position 3 in CaM calcium binding, protein folding, and activation of the Bordetella pertussis adenylate cyclase toxin domain (CyaA-ACD). NMR calcium titration experiments showed that site I in the CaM...

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Bibliographic Details
Main Authors: Christian W. Johns, Natosha L. Finley
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Toxins
Subjects:
calcium
calmodulin
CyaA toxin
NMR
Online Access:https://www.mdpi.com/2072-6651/9/12/389

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