Clinical features of posterior microphthalmic and nanophthalmic eyes
AIM: To clinically differentiate nanophthalmos (NO) and posterior microphthalmos (PM) and to explore the mechanisms related to papillomacular folds (PMF). METHODS: Medical records of 34 unrelated patients with microphthalmos (54 eyes) from April 2009 to October 2017 were retrospectively reviewed....
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2018-11-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.cn/en_publish/2018/11/20181115.pdf |
| _version_ | 1818325129766109184 |
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| author | Jing-Jing Liu Yi-Ye Chen Xiang Zhang Pei-Quan Zhao |
| author_facet | Jing-Jing Liu Yi-Ye Chen Xiang Zhang Pei-Quan Zhao |
| author_sort | Jing-Jing Liu |
| collection | DOAJ |
| description | AIM: To clinically differentiate nanophthalmos (NO) and posterior microphthalmos (PM) and to explore the mechanisms related to papillomacular folds (PMF).
METHODS: Medical records of 34 unrelated patients with microphthalmos (54 eyes) from April 2009 to October 2017 were retrospectively reviewed.
RESULTS: Fourteen eyes of 7 unrelated patients with NO and PM were included in the study. The presenting age of the NO cohort was significantly higher compared with the PM cohort (NO: 27±16y; PM: 3.7±0.6y). PMF was more likely to occur in cases with PM than in NO (25% in NO, 100% in PM). The anatomic features of PMF from optical coherence tomography (OCT) included: ganglion cell layer, inner plexiform layer, inner nuclear layer, outer plexiform layer and outer nuclear layer. In eyes without an apparent PMF (these were all NO eyes), rudimentary fovea without a foveal pit was noted. Four eyes that were NO developed angle closure glaucoma. Three NO eyes developed exudative retinal detachment and were successfully treated with lamellar sclerectomy.
CONCLUSION: Posterior segment changes are pervasive both in PM and NO. Complications like angle closure glaucoma and exudative retinal detachment are likely to occur in eyes with NO but not with PM. Detailed OCT analysis found that PMF was partially a neural retinal issue, suggesting that redundancy of retinal issues involved only inner retinal layers. |
| first_indexed | 2024-12-13T11:39:35Z |
| format | Article |
| id | doaj.art-bcb4171d85ac47739b167e1ff84cc431 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-13T11:39:35Z |
| publishDate | 2018-11-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-bcb4171d85ac47739b167e1ff84cc4312022-12-21T23:47:41ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982018-11-0111111829183410.18240/ijo.2018.11.15Clinical features of posterior microphthalmic and nanophthalmic eyesJing-Jing Liu0Yi-Ye Chen1Xiang Zhang2Pei-Quan Zhao3Department of Ophthalmology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, ChinaDepartment of Ophthalmology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, ChinaDepartment of Ophthalmology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, ChinaDepartment of Ophthalmology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, ChinaAIM: To clinically differentiate nanophthalmos (NO) and posterior microphthalmos (PM) and to explore the mechanisms related to papillomacular folds (PMF). METHODS: Medical records of 34 unrelated patients with microphthalmos (54 eyes) from April 2009 to October 2017 were retrospectively reviewed. RESULTS: Fourteen eyes of 7 unrelated patients with NO and PM were included in the study. The presenting age of the NO cohort was significantly higher compared with the PM cohort (NO: 27±16y; PM: 3.7±0.6y). PMF was more likely to occur in cases with PM than in NO (25% in NO, 100% in PM). The anatomic features of PMF from optical coherence tomography (OCT) included: ganglion cell layer, inner plexiform layer, inner nuclear layer, outer plexiform layer and outer nuclear layer. In eyes without an apparent PMF (these were all NO eyes), rudimentary fovea without a foveal pit was noted. Four eyes that were NO developed angle closure glaucoma. Three NO eyes developed exudative retinal detachment and were successfully treated with lamellar sclerectomy. CONCLUSION: Posterior segment changes are pervasive both in PM and NO. Complications like angle closure glaucoma and exudative retinal detachment are likely to occur in eyes with NO but not with PM. Detailed OCT analysis found that PMF was partially a neural retinal issue, suggesting that redundancy of retinal issues involved only inner retinal layers.http://www.ijo.cn/en_publish/2018/11/20181115.pdfnanophthalmosnon-rhegmatogenous retinal detachmentoptical coherence tomographypapillomacular foldsposterior microphthalmosrudimentary fovea |
| spellingShingle | Jing-Jing Liu Yi-Ye Chen Xiang Zhang Pei-Quan Zhao Clinical features of posterior microphthalmic and nanophthalmic eyes International Journal of Ophthalmology nanophthalmos non-rhegmatogenous retinal detachment optical coherence tomography papillomacular folds posterior microphthalmos rudimentary fovea |
| title | Clinical features of posterior microphthalmic and nanophthalmic eyes |
| title_full | Clinical features of posterior microphthalmic and nanophthalmic eyes |
| title_fullStr | Clinical features of posterior microphthalmic and nanophthalmic eyes |
| title_full_unstemmed | Clinical features of posterior microphthalmic and nanophthalmic eyes |
| title_short | Clinical features of posterior microphthalmic and nanophthalmic eyes |
| title_sort | clinical features of posterior microphthalmic and nanophthalmic eyes |
| topic | nanophthalmos non-rhegmatogenous retinal detachment optical coherence tomography papillomacular folds posterior microphthalmos rudimentary fovea |
| url | http://www.ijo.cn/en_publish/2018/11/20181115.pdf |
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