Production of ULBP1-KO pigs with human CD55 expression using CRISPR technology

Production of ULBP1-KO pigs with human CD55 expression using CRISPR technology

The shortage of organs for transplantation is a well-known issue of modern medicine. The domestic pig has proved to be most suitable for xenotransplantation purposes. It is necessary to modify the pig genome to eliminate the immunological differences resulting from its phylogenetic remoteness from h...

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Bibliographic Details
Main Authors: Agnieszka Nowak-Terpiłowska, Daniel Lipiński, Magdalena Hryhorowicz, Wojciech Juzwa, Jacek Jura, Ryszard Słomski, Natalia Mazurkiewicz, Barbara Gawrońska, Joanna Zeyland
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Applied Animal Research
Subjects:
crispr-cas9
ul-16 binding protein
pigs
xenotransplantation
cd55 (daf)
Online Access:http://dx.doi.org/10.1080/09712119.2020.1735396

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