An exploratory study of delayed flash visual evoked potential P2 wave latency in subcortical arteriosclerotic encephalopathy
Abstract Background Patients with cognitive dysfunction may present with significantly prolonged the P2 wave latency of flash visual evoked potential. However, no studies have been reported on whether the P2 wave latency of flash visual evoked potential is prolonged in patients with subcortical arte...
| المؤلفون الرئيسيون: | , , , |
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| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
BMC
2023-10-01
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| سلاسل: | BMC Neurology |
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://doi.org/10.1186/s12883-023-03388-z |
| _version_ | 1827633850842349568 |
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| author | Lei Duan Yu Ding Gao-hui Sun Yun-tao Li |
| author_facet | Lei Duan Yu Ding Gao-hui Sun Yun-tao Li |
| author_sort | Lei Duan |
| collection | DOAJ |
| description | Abstract Background Patients with cognitive dysfunction may present with significantly prolonged the P2 wave latency of flash visual evoked potential. However, no studies have been reported on whether the P2 wave latency of flash visual evoked potential is prolonged in patients with subcortical arteriosclerotic encephalopathy (SAE). Objective To examine the relationship between flash visual evoked potential P2 wave latency (FVEP-P2 wave latency) and cognitive impairment in patients with SAE. Methods Overall, we recruited 38 SAE patients as the observation cohort (OC) and 34 healthy volunteers as the control cohort (CC). We measured the FVEP-P2 wave latency for both groups. The SAE patients’ cognitive abilities were evaluated via mini-mental state examination (MMSE) and the association between the latency of FVEP-P2 and MMSE score was explored by Pearsons´s correlation test. Results There is no significant difference between OC (21 males and 17 females; 68.6 ± 6.7 years of age and 9.6 ± 2.8 years of education) and CC (19 males and 15 females; 65.3 ± 5.9 years of age and 10.1 ± 2.6 years of education) in gender and age composition and education level. The FVEP-P2 wave latency of the CC group was (108.80 ± 16.70) ms and the OC FVEP-P2 wave latency was (152.31 ± 20.70) ms. The OC FVEP-P2 wave latency was significantly longer than the CC (P < 0.05). In terms of MMSE scores, the MMSE scores of CC was (28.41 ± 2.34), and that of OC was (9.08 ± 4.39). Compared to the CC, the OC MMSE score was significantly lower (P < 0.05). In addition, the FVEP-P2 wave latency was inversely related to the MMSE (r = -0.4465, P < 0.05) in SAE patients. Conclusion The FVEP-P2 wave latency wave latency was significantly prolonged in SAE patients and strongly associated with the degree of cognitive dysfunction. |
| first_indexed | 2024-03-09T15:05:15Z |
| format | Article |
| id | doaj.art-bcb51a61bc504de69940d2b3332f355c |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-03-09T15:05:15Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-bcb51a61bc504de69940d2b3332f355c2023-11-26T13:42:01ZengBMCBMC Neurology1471-23772023-10-012311510.1186/s12883-023-03388-zAn exploratory study of delayed flash visual evoked potential P2 wave latency in subcortical arteriosclerotic encephalopathyLei Duan0Yu Ding1Gao-hui Sun2Yun-tao Li3Department of Encephalopathy, Nanjing Jiangning Hospital of Traditional Chinese MedicineDepartment of Encephalopathy, Nanjing Jiangning Hospital of Traditional Chinese MedicineDepartment of Neurology, the Second Affiliated Hospital of Nanjing Medical UniversityDepartment of General Medicine, the Second Affiliated Hospital of Nanjing Medical UniversityAbstract Background Patients with cognitive dysfunction may present with significantly prolonged the P2 wave latency of flash visual evoked potential. However, no studies have been reported on whether the P2 wave latency of flash visual evoked potential is prolonged in patients with subcortical arteriosclerotic encephalopathy (SAE). Objective To examine the relationship between flash visual evoked potential P2 wave latency (FVEP-P2 wave latency) and cognitive impairment in patients with SAE. Methods Overall, we recruited 38 SAE patients as the observation cohort (OC) and 34 healthy volunteers as the control cohort (CC). We measured the FVEP-P2 wave latency for both groups. The SAE patients’ cognitive abilities were evaluated via mini-mental state examination (MMSE) and the association between the latency of FVEP-P2 and MMSE score was explored by Pearsons´s correlation test. Results There is no significant difference between OC (21 males and 17 females; 68.6 ± 6.7 years of age and 9.6 ± 2.8 years of education) and CC (19 males and 15 females; 65.3 ± 5.9 years of age and 10.1 ± 2.6 years of education) in gender and age composition and education level. The FVEP-P2 wave latency of the CC group was (108.80 ± 16.70) ms and the OC FVEP-P2 wave latency was (152.31 ± 20.70) ms. The OC FVEP-P2 wave latency was significantly longer than the CC (P < 0.05). In terms of MMSE scores, the MMSE scores of CC was (28.41 ± 2.34), and that of OC was (9.08 ± 4.39). Compared to the CC, the OC MMSE score was significantly lower (P < 0.05). In addition, the FVEP-P2 wave latency was inversely related to the MMSE (r = -0.4465, P < 0.05) in SAE patients. Conclusion The FVEP-P2 wave latency wave latency was significantly prolonged in SAE patients and strongly associated with the degree of cognitive dysfunction.https://doi.org/10.1186/s12883-023-03388-zFlash visual evoked potential P2 wave latencyMMSESubcortical arteriosclerotic encephalopathyCognitive dysfunction |
| spellingShingle | Lei Duan Yu Ding Gao-hui Sun Yun-tao Li An exploratory study of delayed flash visual evoked potential P2 wave latency in subcortical arteriosclerotic encephalopathy BMC Neurology Flash visual evoked potential P2 wave latency MMSE Subcortical arteriosclerotic encephalopathy Cognitive dysfunction |
| title | An exploratory study of delayed flash visual evoked potential P2 wave latency in subcortical arteriosclerotic encephalopathy |
| title_full | An exploratory study of delayed flash visual evoked potential P2 wave latency in subcortical arteriosclerotic encephalopathy |
| title_fullStr | An exploratory study of delayed flash visual evoked potential P2 wave latency in subcortical arteriosclerotic encephalopathy |
| title_full_unstemmed | An exploratory study of delayed flash visual evoked potential P2 wave latency in subcortical arteriosclerotic encephalopathy |
| title_short | An exploratory study of delayed flash visual evoked potential P2 wave latency in subcortical arteriosclerotic encephalopathy |
| title_sort | exploratory study of delayed flash visual evoked potential p2 wave latency in subcortical arteriosclerotic encephalopathy |
| topic | Flash visual evoked potential P2 wave latency MMSE Subcortical arteriosclerotic encephalopathy Cognitive dysfunction |
| url | https://doi.org/10.1186/s12883-023-03388-z |
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