New treatments/targets for primary biliary cholangitis
Summary: Primary biliary cholangitis (PBC) is an autoimmune, cholestatic, chronic liver disease that ultimately progresses towards cirrhosis and liver failure if untreated. While ursodeoxycholic acid has been established as standard of care for PBC in the last few decades, significant advances in se...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-09-01
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| Series: | JHEP Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589555919300539 |
| _version_ | 1811238988525076480 |
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| author | Christophe Corpechot Raoul Poupon Olivier Chazouillères |
| author_facet | Christophe Corpechot Raoul Poupon Olivier Chazouillères |
| author_sort | Christophe Corpechot |
| collection | DOAJ |
| description | Summary: Primary biliary cholangitis (PBC) is an autoimmune, cholestatic, chronic liver disease that ultimately progresses towards cirrhosis and liver failure if untreated. While ursodeoxycholic acid has been established as standard of care for PBC in the last few decades, significant advances in second-line treatment options have recently been made and new therapeutic developments are currently under evaluation. The purpose of this article is to provide the clinician with an overview of the current treatment options and future opportunities for patients with PBC. Keywords: PBC, ursodeoxycholic acid, obeticholic acid, fibrates, FXR, PPAR, cholestasis, inflammation, liver disease |
| first_indexed | 2024-04-12T12:52:00Z |
| format | Article |
| id | doaj.art-bcb68a2371c14ae38ff9f02724567171 |
| institution | Directory Open Access Journal |
| issn | 2589-5559 |
| language | English |
| last_indexed | 2024-04-12T12:52:00Z |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JHEP Reports |
| spelling | doaj.art-bcb68a2371c14ae38ff9f027245671712022-12-22T03:32:28ZengElsevierJHEP Reports2589-55592019-09-0113203213New treatments/targets for primary biliary cholangitisChristophe Corpechot0Raoul Poupon1Olivier Chazouillères2Reference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis, Hepatology Department, Saint-Antoine Hospital, Assistance Publique – Hôpitaux de Paris (APHP); INSERM UMR_S938, Saint-Antoine Research Center, Sorbonne University, Paris, France; Corresponding author. Address: Hepatology Department, Saint Antoine Hospital, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France.Reference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis, Hepatology Department, Saint-Antoine Hospital, Assistance Publique – Hôpitaux de Paris (APHP); INSERM UMR_S938, Saint-Antoine Research Center, Sorbonne University, Paris, FranceReference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis, Hepatology Department, Saint-Antoine Hospital, Assistance Publique – Hôpitaux de Paris (APHP); INSERM UMR_S938, Saint-Antoine Research Center, Sorbonne University, Paris, FranceSummary: Primary biliary cholangitis (PBC) is an autoimmune, cholestatic, chronic liver disease that ultimately progresses towards cirrhosis and liver failure if untreated. While ursodeoxycholic acid has been established as standard of care for PBC in the last few decades, significant advances in second-line treatment options have recently been made and new therapeutic developments are currently under evaluation. The purpose of this article is to provide the clinician with an overview of the current treatment options and future opportunities for patients with PBC. Keywords: PBC, ursodeoxycholic acid, obeticholic acid, fibrates, FXR, PPAR, cholestasis, inflammation, liver diseasehttp://www.sciencedirect.com/science/article/pii/S2589555919300539 |
| spellingShingle | Christophe Corpechot Raoul Poupon Olivier Chazouillères New treatments/targets for primary biliary cholangitis JHEP Reports |
| title | New treatments/targets for primary biliary cholangitis |
| title_full | New treatments/targets for primary biliary cholangitis |
| title_fullStr | New treatments/targets for primary biliary cholangitis |
| title_full_unstemmed | New treatments/targets for primary biliary cholangitis |
| title_short | New treatments/targets for primary biliary cholangitis |
| title_sort | new treatments targets for primary biliary cholangitis |
| url | http://www.sciencedirect.com/science/article/pii/S2589555919300539 |
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