Cytotoxic Dammarane-Type Triterpenoids from <i>Aglaia cucullata</i> Peel Fruit
Four triterpenoids, known as dammarane-type, dammaradienone (1), 20(S),25-epoxy-5α-dammar-20-en-3-one (2), 20(S)-5α-dammar-24-en-3α,20-diol-3-acetate (3) and 3α-acetyl-20S,24S-epoxy-25-hydroxydammarane (4), were isolated from Aglaia cucullata peel fruit. The structures of isolated compounds were ide...
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| Format: | Article |
| Language: | English |
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Department of Chemistry, Universitas Gadjah Mada
2024-02-01
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| Series: | Indonesian Journal of Chemistry |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/83694 |
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| author | Intan Hawina Anjari Desi Harneti Kindi Farabi Al Arofatus Naini Ace Tatang Hidayat Risyandi Anwar Hadi Kuncoro Mohamad Nurul Azmi Unang Supratman |
| author_facet | Intan Hawina Anjari Desi Harneti Kindi Farabi Al Arofatus Naini Ace Tatang Hidayat Risyandi Anwar Hadi Kuncoro Mohamad Nurul Azmi Unang Supratman |
| author_sort | Intan Hawina Anjari |
| collection | DOAJ |
| description | Four triterpenoids, known as dammarane-type, dammaradienone (1), 20(S),25-epoxy-5α-dammar-20-en-3-one (2), 20(S)-5α-dammar-24-en-3α,20-diol-3-acetate (3) and 3α-acetyl-20S,24S-epoxy-25-hydroxydammarane (4), were isolated from Aglaia cucullata peel fruit. The structures of isolated compounds were identified based on their HR-TOFMS data and extensive NMR spectroscopic analysis, as well as compared with literature data. Compounds 1-4 were assessed for cytotoxic effects against HeLa cervical and B16-F10 melanoma skin cancer cells. All compounds showed moderate to weak activity against B16-F10 cancer cells, while compound 2 exhibited the strongest activity against HeLa cancer cells with IC50 of 7.10 µg/mL indicating that the existence of an epoxy moiety at the side chain increases the cytotoxicity to HeLa cells. |
| first_indexed | 2024-03-08T08:53:46Z |
| format | Article |
| id | doaj.art-bcb6eb7b2f914a4eba64860c0200a394 |
| institution | Directory Open Access Journal |
| issn | 1411-9420 2460-1578 |
| language | English |
| last_indexed | 2024-03-08T08:53:46Z |
| publishDate | 2024-02-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj.art-bcb6eb7b2f914a4eba64860c0200a3942024-02-01T07:39:51ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782024-02-01241678010.22146/ijc.8369435180Cytotoxic Dammarane-Type Triterpenoids from <i>Aglaia cucullata</i> Peel FruitIntan Hawina Anjari0Desi Harneti1Kindi Farabi2Al Arofatus Naini3Ace Tatang Hidayat4Risyandi Anwar5Hadi Kuncoro6Mohamad Nurul Azmi7Unang Supratman8Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia; Central Laboratory of Universitas Padjadjaran, Jl. Raya Bandung-Sumedang, Km. 21, Jatinangor, Sumedang 45363, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia; Central Laboratory of Universitas Padjadjaran, Jl. Raya Bandung-Sumedang, Km. 21, Jatinangor, Sumedang 45363, IndonesiaHerbal Medicine Research, Department of Paediatric Dentistry, Faculty of Dental Medicine, University of Muhammadiyah Semarang, Semarang 50272, IndonesiaFaculty of Pharmacy, Universitas Mulawarman, Samarinda 75123, IndonesiaSchool of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, MalaysiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia; Central Laboratory of Universitas Padjadjaran, Jl. Raya Bandung-Sumedang, Km. 21, Jatinangor, Sumedang 45363, IndonesiaFour triterpenoids, known as dammarane-type, dammaradienone (1), 20(S),25-epoxy-5α-dammar-20-en-3-one (2), 20(S)-5α-dammar-24-en-3α,20-diol-3-acetate (3) and 3α-acetyl-20S,24S-epoxy-25-hydroxydammarane (4), were isolated from Aglaia cucullata peel fruit. The structures of isolated compounds were identified based on their HR-TOFMS data and extensive NMR spectroscopic analysis, as well as compared with literature data. Compounds 1-4 were assessed for cytotoxic effects against HeLa cervical and B16-F10 melanoma skin cancer cells. All compounds showed moderate to weak activity against B16-F10 cancer cells, while compound 2 exhibited the strongest activity against HeLa cancer cells with IC50 of 7.10 µg/mL indicating that the existence of an epoxy moiety at the side chain increases the cytotoxicity to HeLa cells.https://jurnal.ugm.ac.id/ijc/article/view/83694aglaia cucullateb16-f10dammarane-typecytotoxic activityhela |
| spellingShingle | Intan Hawina Anjari Desi Harneti Kindi Farabi Al Arofatus Naini Ace Tatang Hidayat Risyandi Anwar Hadi Kuncoro Mohamad Nurul Azmi Unang Supratman Cytotoxic Dammarane-Type Triterpenoids from <i>Aglaia cucullata</i> Peel Fruit Indonesian Journal of Chemistry aglaia cucullate b16-f10 dammarane-type cytotoxic activity hela |
| title | Cytotoxic Dammarane-Type Triterpenoids from <i>Aglaia cucullata</i> Peel Fruit |
| title_full | Cytotoxic Dammarane-Type Triterpenoids from <i>Aglaia cucullata</i> Peel Fruit |
| title_fullStr | Cytotoxic Dammarane-Type Triterpenoids from <i>Aglaia cucullata</i> Peel Fruit |
| title_full_unstemmed | Cytotoxic Dammarane-Type Triterpenoids from <i>Aglaia cucullata</i> Peel Fruit |
| title_short | Cytotoxic Dammarane-Type Triterpenoids from <i>Aglaia cucullata</i> Peel Fruit |
| title_sort | cytotoxic dammarane type triterpenoids from i aglaia cucullata i peel fruit |
| topic | aglaia cucullate b16-f10 dammarane-type cytotoxic activity hela |
| url | https://jurnal.ugm.ac.id/ijc/article/view/83694 |
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