Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats
Moderate consumption of wine has a protective effect on the cardiovascular system. This study proposes to investigate the cardiovascular protective effect of the lyophilized red wine RIO SOL Cabernet-Sauvignon (LRW-RSCS), produced in Northeastern Brazil, in SHR. Sixteen different phenolic compounds,...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646462100517X |
| _version_ | 1828923424844546048 |
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| author | Natália T.M. Calzerra Mayara P. Melo Pablo F. Santos Kívia S. Assis Priscilla M.P. Maciel Renata L.P. Vieira Fátima de L.A.A. Azevedo Angela M.T.M. Cordeiro Bruno R.L.A. Meireles Islania G.A. Araújo Robson C. Veras Isac A. Medeiros |
| author_facet | Natália T.M. Calzerra Mayara P. Melo Pablo F. Santos Kívia S. Assis Priscilla M.P. Maciel Renata L.P. Vieira Fátima de L.A.A. Azevedo Angela M.T.M. Cordeiro Bruno R.L.A. Meireles Islania G.A. Araújo Robson C. Veras Isac A. Medeiros |
| author_sort | Natália T.M. Calzerra |
| collection | DOAJ |
| description | Moderate consumption of wine has a protective effect on the cardiovascular system. This study proposes to investigate the cardiovascular protective effect of the lyophilized red wine RIO SOL Cabernet-Sauvignon (LRW-RSCS), produced in Northeastern Brazil, in SHR. Sixteen different phenolic compounds, such as gentisic acid, catechin, and resveratrol were identified in LRW-RSCS using high-performance liquid chromatography. LRW-RSCS presented anti-radical activity. Six-week treatment of SHR with LRW-RSCS (100 or 300 mg/Kg/day intra-gastrically) reduced blood pressure and hypercontractility, and improved mesenteric resistance artery endothelial function. The protective effect of LRW-RSCS on endothelial function, mediated relaxation involving both higher endothelial-NO and -EDHF. LRW-RSCS intake reduced vessel wall thickness, media-to-lumen ratio, collagen vascular deposition, and vessel oxidative stress. LRW-RSCS also attenuated platelet hyper aggregation and ROS generation. The results demonstrate that LRW-RSCS from Northeastern Brazil presents cardiovascular protective effect in SHR, at least in part by decreasing oxidative stress. |
| first_indexed | 2024-12-13T22:37:59Z |
| format | Article |
| id | doaj.art-bcb87fe0e79543299d747e37e3f3a6db |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-13T22:37:59Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-bcb87fe0e79543299d747e37e3f3a6db2022-12-21T23:28:56ZengElsevierJournal of Functional Foods1756-46462022-01-0188104868Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive ratsNatália T.M. Calzerra0Mayara P. Melo1Pablo F. Santos2Kívia S. Assis3Priscilla M.P. Maciel4Renata L.P. Vieira5Fátima de L.A.A. Azevedo6Angela M.T.M. Cordeiro7Bruno R.L.A. Meireles8Islania G.A. Araújo9Robson C. Veras10Isac A. Medeiros11Departamento de Fisiologia e Farmacologia, Centro de Biociências (CB), Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco 50670901, BrasilDepartamento de Ciências Farmacêuticas, Centro de Ciências da Saúde (CCS), Universidade Federal da Paraíba, Cidade Universitária, Campus I, João Pessoa, Paraíba 58.059-900, BrazilDepartamento de Ciências Farmacêuticas, Centro de Ciências da Saúde (CCS), Universidade Federal da Paraíba, Cidade Universitária, Campus I, João Pessoa, Paraíba 58.059-900, BrazilPrograma de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba (UFPB), João Pessoa 58059-900, BrazilPrograma de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba (UFPB), João Pessoa 58059-900, BrazilPrograma de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba (UFPB), João Pessoa 58059-900, BrazilPrograma de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba (UFPB), João Pessoa 58059-900, BrazilDepartamento de Tecnologia de Alimentos, Centro de Tecnologia e Desenvolvimento Regional, Universidade Federal de Paraíba, Campus I, João Pessoa, Paraíba 58055-000, BrazilDepartamento de Tecnologia de Alimentos, Centro de Tecnologia e Desenvolvimento Regional, Universidade Federal de Paraíba, Campus I, João Pessoa, Paraíba 58055-000, BrazilDepartamento de Ciências Farmacêuticas, Centro de Ciências da Saúde (CCS), Universidade Federal da Paraíba, Cidade Universitária, Campus I, João Pessoa, Paraíba 58.059-900, BrazilDepartamento de Ciências Farmacêuticas, Centro de Ciências da Saúde (CCS), Universidade Federal da Paraíba, Cidade Universitária, Campus I, João Pessoa, Paraíba 58.059-900, BrazilDepartamento de Ciências Farmacêuticas, Centro de Ciências da Saúde (CCS), Universidade Federal da Paraíba, Cidade Universitária, Campus I, João Pessoa, Paraíba 58.059-900, Brazil; Corresponding author at: Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal da Paraíba, Cidade Universitária, Campus I, CEP 58.051-900 João Pessoa, PB, Brazil.Moderate consumption of wine has a protective effect on the cardiovascular system. This study proposes to investigate the cardiovascular protective effect of the lyophilized red wine RIO SOL Cabernet-Sauvignon (LRW-RSCS), produced in Northeastern Brazil, in SHR. Sixteen different phenolic compounds, such as gentisic acid, catechin, and resveratrol were identified in LRW-RSCS using high-performance liquid chromatography. LRW-RSCS presented anti-radical activity. Six-week treatment of SHR with LRW-RSCS (100 or 300 mg/Kg/day intra-gastrically) reduced blood pressure and hypercontractility, and improved mesenteric resistance artery endothelial function. The protective effect of LRW-RSCS on endothelial function, mediated relaxation involving both higher endothelial-NO and -EDHF. LRW-RSCS intake reduced vessel wall thickness, media-to-lumen ratio, collagen vascular deposition, and vessel oxidative stress. LRW-RSCS also attenuated platelet hyper aggregation and ROS generation. The results demonstrate that LRW-RSCS from Northeastern Brazil presents cardiovascular protective effect in SHR, at least in part by decreasing oxidative stress.http://www.sciencedirect.com/science/article/pii/S175646462100517XEssential hypertensionBrazilian red wineEndothelial dysfunctionVascular alterationsMesenteric resistance arteriesSpontaneously hypertensive rats |
| spellingShingle | Natália T.M. Calzerra Mayara P. Melo Pablo F. Santos Kívia S. Assis Priscilla M.P. Maciel Renata L.P. Vieira Fátima de L.A.A. Azevedo Angela M.T.M. Cordeiro Bruno R.L.A. Meireles Islania G.A. Araújo Robson C. Veras Isac A. Medeiros Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats Journal of Functional Foods Essential hypertension Brazilian red wine Endothelial dysfunction Vascular alterations Mesenteric resistance arteries Spontaneously hypertensive rats |
| title | Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats |
| title_full | Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats |
| title_fullStr | Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats |
| title_full_unstemmed | Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats |
| title_short | Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats |
| title_sort | cardiovascular protection effect of a northeastern brazilian lyophilized red wine in spontaneously hypertensive rats |
| topic | Essential hypertension Brazilian red wine Endothelial dysfunction Vascular alterations Mesenteric resistance arteries Spontaneously hypertensive rats |
| url | http://www.sciencedirect.com/science/article/pii/S175646462100517X |
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