Amidoalkylation of heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]- 2'-chloroacetamide and antimicrobial activity of derivatives
Amidoalkylation of secondary heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]-2'-chloroacetamide resulted the new compounds 5-10 that contain 1,3,4-thiadiazole-5-thione moiety alongside pyperidine, morpholine, and cytisine fragments. In vitro screening of antimicrobial activit...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Growing Science
2021-01-01
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| Series: | Current Chemistry Letters |
| Online Access: | http://www.growingscience.com/ccl/Vol10/ccl_2021_21.pdf |
| _version_ | 1818279515943600128 |
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| author | Turdibek Toshmurodov Abdukhakim Ziyaev Sobirdjan Sasmakov Jaloliddin Abdurakhmanov Mavluda Ziyaeva Dilnoza Ismailova Shakhnoz Azimova |
| author_facet | Turdibek Toshmurodov Abdukhakim Ziyaev Sobirdjan Sasmakov Jaloliddin Abdurakhmanov Mavluda Ziyaeva Dilnoza Ismailova Shakhnoz Azimova |
| author_sort | Turdibek Toshmurodov |
| collection | DOAJ |
| description | Amidoalkylation of secondary heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]-2'-chloroacetamide resulted the new compounds 5-10 that contain 1,3,4-thiadiazole-5-thione moiety alongside pyperidine, morpholine, and cytisine fragments. In vitro screening of antimicrobial activity of synthesized compounds showed that N-[5-(amylsulfanyl)-1,3,4-thiadiazol-2-yl]-2'-morpholinacetamide exhibited an appreciable antibacterial activity against gram-negative bacteria of Escherichia coli (inhibition zone diameter of 16 mm) and gram-positive bacteria of Staphylococcus aureus and Bacillus subtilis (10-13 mm). |
| first_indexed | 2024-12-12T23:34:34Z |
| format | Article |
| id | doaj.art-bcb8b005f02548c6b094e445a4ddeabc |
| institution | Directory Open Access Journal |
| issn | 1927-7296 1927-730X |
| language | English |
| last_indexed | 2024-12-12T23:34:34Z |
| publishDate | 2021-01-01 |
| publisher | Growing Science |
| record_format | Article |
| series | Current Chemistry Letters |
| spelling | doaj.art-bcb8b005f02548c6b094e445a4ddeabc2022-12-22T00:07:35ZengGrowing ScienceCurrent Chemistry Letters1927-72961927-730X2021-01-0110442743410.5267/j.ccl.2021.5.002Amidoalkylation of heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]- 2'-chloroacetamide and antimicrobial activity of derivativesTurdibek ToshmurodovAbdukhakim ZiyaevSobirdjan SasmakovJaloliddin AbdurakhmanovMavluda ZiyaevaDilnoza IsmailovaShakhnoz AzimovaAmidoalkylation of secondary heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]-2'-chloroacetamide resulted the new compounds 5-10 that contain 1,3,4-thiadiazole-5-thione moiety alongside pyperidine, morpholine, and cytisine fragments. In vitro screening of antimicrobial activity of synthesized compounds showed that N-[5-(amylsulfanyl)-1,3,4-thiadiazol-2-yl]-2'-morpholinacetamide exhibited an appreciable antibacterial activity against gram-negative bacteria of Escherichia coli (inhibition zone diameter of 16 mm) and gram-positive bacteria of Staphylococcus aureus and Bacillus subtilis (10-13 mm).http://www.growingscience.com/ccl/Vol10/ccl_2021_21.pdf |
| spellingShingle | Turdibek Toshmurodov Abdukhakim Ziyaev Sobirdjan Sasmakov Jaloliddin Abdurakhmanov Mavluda Ziyaeva Dilnoza Ismailova Shakhnoz Azimova Amidoalkylation of heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]- 2'-chloroacetamide and antimicrobial activity of derivatives Current Chemistry Letters |
| title | Amidoalkylation of heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]- 2'-chloroacetamide and antimicrobial activity of derivatives |
| title_full | Amidoalkylation of heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]- 2'-chloroacetamide and antimicrobial activity of derivatives |
| title_fullStr | Amidoalkylation of heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]- 2'-chloroacetamide and antimicrobial activity of derivatives |
| title_full_unstemmed | Amidoalkylation of heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]- 2'-chloroacetamide and antimicrobial activity of derivatives |
| title_short | Amidoalkylation of heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]- 2'-chloroacetamide and antimicrobial activity of derivatives |
| title_sort | amidoalkylation of heterocyclic amines by n 5 alkylsulfanyl 1 3 4 thiadiazol 2 yl 2 chloroacetamide and antimicrobial activity of derivatives |
| url | http://www.growingscience.com/ccl/Vol10/ccl_2021_21.pdf |
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