Hepatoprotective and Antioxidant Effects of Resveratrol Against Vincristine Sulfate Toxicity in Mice
Background and Objective: Vincristine is an important anticancer drug, which is highly toxic to the liver. It is a naturally occurring polyphenol found in many plants. Some studies have shown the anti-inflammatory and antioxidant effects of resveratrol. This study was conducted to determine the hepa...
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| Format: | Article |
| Language: | fas |
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Golestan University of Medical Sciences
2023-01-01
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| Series: | مجله دانشگاه علوم پزشکی گرگان |
| Subjects: | |
| Online Access: | http://goums.ac.ir/journal/article-1-4130-en.html |
| _version_ | 1797850256489054208 |
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| author | Mahdi Vahidbalan Mohammadreza Nasirzadeh |
| author_facet | Mahdi Vahidbalan Mohammadreza Nasirzadeh |
| author_sort | Mahdi Vahidbalan |
| collection | DOAJ |
| description | Background and Objective: Vincristine is an important anticancer drug, which is highly toxic to the liver. It is a naturally occurring polyphenol found in many plants. Some studies have shown the anti-inflammatory and antioxidant effects of resveratrol. This study was conducted to determine the hepatoprotective and antioxidant effects of resveratrol against vincristine-induced toxicity in mice.
Methods: In this experimental study, 32 female NMRI mice weighing 25-30 grams were randomly divided into four groups (n=8): control, vincristine, vincristine + resveratrol, and resveratrol. The animals received vincristine intraperitoneally at a dose of 3 mg/kg/bw once a week for four weeks. They also received resveratrol at a dose of 30 mg/kg for 28 days through gastric gavage. At the end of the study, the activity of alanine transaminase (ALT) and aspartate transaminase (AST) were measured. The level of antioxidant enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPX), malondialdehyde (MDA) as well as total antioxidant capacity (TAC) was measured in the liver tissue of mice.
Results: The activities of ALT, AST, SOD, and GPX decreased in the vincristine group compared to the control group, while MDA level increased significantly (P˂0.05). Treatment with resveratrol in the vincristine + resveratrol group improved the evaluated parameters compared to the vincristine group (P˂0.05).
Conclusion: Resveratrol has protective and antioxidant effects against vincristine-induced oxidative damage in the liver of mice. |
| first_indexed | 2024-04-09T18:57:26Z |
| format | Article |
| id | doaj.art-bcb96d1f2c8d4d36af6c2c71230656d4 |
| institution | Directory Open Access Journal |
| issn | 1562-4765 2008-4080 |
| language | fas |
| last_indexed | 2024-04-09T18:57:26Z |
| publishDate | 2023-01-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی گرگان |
| spelling | doaj.art-bcb96d1f2c8d4d36af6c2c71230656d42023-04-09T08:46:19ZfasGolestan University of Medical Sciencesمجله دانشگاه علوم پزشکی گرگان1562-47652008-40802023-01-012444450Hepatoprotective and Antioxidant Effects of Resveratrol Against Vincristine Sulfate Toxicity in MiceMahdi Vahidbalan0Mohammadreza Nasirzadeh1 Veterinarian, Faculty of Veterinary Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran. Assistant Professor, Department of Physiology, Faculty of Veterinary Medicine, Tabriz Medical Sciences,, Islamic Azad University, Tabriz, Iran. Background and Objective: Vincristine is an important anticancer drug, which is highly toxic to the liver. It is a naturally occurring polyphenol found in many plants. Some studies have shown the anti-inflammatory and antioxidant effects of resveratrol. This study was conducted to determine the hepatoprotective and antioxidant effects of resveratrol against vincristine-induced toxicity in mice. Methods: In this experimental study, 32 female NMRI mice weighing 25-30 grams were randomly divided into four groups (n=8): control, vincristine, vincristine + resveratrol, and resveratrol. The animals received vincristine intraperitoneally at a dose of 3 mg/kg/bw once a week for four weeks. They also received resveratrol at a dose of 30 mg/kg for 28 days through gastric gavage. At the end of the study, the activity of alanine transaminase (ALT) and aspartate transaminase (AST) were measured. The level of antioxidant enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPX), malondialdehyde (MDA) as well as total antioxidant capacity (TAC) was measured in the liver tissue of mice. Results: The activities of ALT, AST, SOD, and GPX decreased in the vincristine group compared to the control group, while MDA level increased significantly (P˂0.05). Treatment with resveratrol in the vincristine + resveratrol group improved the evaluated parameters compared to the vincristine group (P˂0.05). Conclusion: Resveratrol has protective and antioxidant effects against vincristine-induced oxidative damage in the liver of mice.http://goums.ac.ir/journal/article-1-4130-en.htmlvincristineresveratrolliveroxidative stressmice |
| spellingShingle | Mahdi Vahidbalan Mohammadreza Nasirzadeh Hepatoprotective and Antioxidant Effects of Resveratrol Against Vincristine Sulfate Toxicity in Mice مجله دانشگاه علوم پزشکی گرگان vincristine resveratrol liver oxidative stress mice |
| title | Hepatoprotective and Antioxidant Effects of Resveratrol Against Vincristine Sulfate Toxicity in Mice |
| title_full | Hepatoprotective and Antioxidant Effects of Resveratrol Against Vincristine Sulfate Toxicity in Mice |
| title_fullStr | Hepatoprotective and Antioxidant Effects of Resveratrol Against Vincristine Sulfate Toxicity in Mice |
| title_full_unstemmed | Hepatoprotective and Antioxidant Effects of Resveratrol Against Vincristine Sulfate Toxicity in Mice |
| title_short | Hepatoprotective and Antioxidant Effects of Resveratrol Against Vincristine Sulfate Toxicity in Mice |
| title_sort | hepatoprotective and antioxidant effects of resveratrol against vincristine sulfate toxicity in mice |
| topic | vincristine resveratrol liver oxidative stress mice |
| url | http://goums.ac.ir/journal/article-1-4130-en.html |
| work_keys_str_mv | AT mahdivahidbalan hepatoprotectiveandantioxidanteffectsofresveratrolagainstvincristinesulfatetoxicityinmice AT mohammadrezanasirzadeh hepatoprotectiveandantioxidanteffectsofresveratrolagainstvincristinesulfatetoxicityinmice |