Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and Wound Healing
Melanoma is a serious malignant skin tumor. Effectively eliminating melanoma and healing after-surgical wounds are always challenges in clinical studies. To address these problems, we propose manganese-doped calcium silicate nanowire-incorporated alginate hydrogels (named MCSA hydrogels) for in situ...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2021-01-01
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| Series: | Research |
| Online Access: | http://dx.doi.org/10.34133/2021/9780943 |
| _version_ | 1797282582357868544 |
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| author | Zhongcao Wu Hui Zhuang Bing Ma Yin Xiao Bahattin Koc Yufang Zhu Chengtie Wu |
| author_facet | Zhongcao Wu Hui Zhuang Bing Ma Yin Xiao Bahattin Koc Yufang Zhu Chengtie Wu |
| author_sort | Zhongcao Wu |
| collection | DOAJ |
| description | Melanoma is a serious malignant skin tumor. Effectively eliminating melanoma and healing after-surgical wounds are always challenges in clinical studies. To address these problems, we propose manganese-doped calcium silicate nanowire-incorporated alginate hydrogels (named MCSA hydrogels) for in situ photothermal ablation of melanoma followed by the wound healing process. The proposed MCSA hydrogel had controllable gelation properties, reasonable strength, and excellent bioactivity due to the incorporated calcium silicate nanowires as the in situ cross-linking agents and bioactive components. The doping of manganese into calcium silicate nanowires gave them excellent photothermal effects for eradicating melanoma effectively under near infrared (NIR) irradiation. Moreover, the synergistic effect of manganese and silicon in the MCSA hydrogel effectively promotes migration and proliferation of vascular endothelial cells and promotes angiogenesis. Hence, such bifunctional bioactive hydrogels could achieve combined functions of photothermal therapy and wound healing, showing great promise for melanoma therapy and tissue regeneration. |
| first_indexed | 2024-03-07T17:15:09Z |
| format | Article |
| id | doaj.art-bcba1a94b7954677a6d57a1c2dff6646 |
| institution | Directory Open Access Journal |
| issn | 2639-5274 |
| language | English |
| last_indexed | 2024-03-07T17:15:09Z |
| publishDate | 2021-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Research |
| spelling | doaj.art-bcba1a94b7954677a6d57a1c2dff66462024-03-02T23:14:48ZengAmerican Association for the Advancement of Science (AAAS)Research2639-52742021-01-01202110.34133/2021/9780943Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and Wound HealingZhongcao Wu0Hui Zhuang1Bing Ma2Yin Xiao3Bahattin Koc4Yufang Zhu5Chengtie Wu6State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China; School of Materials Science and Engineering, Shanghai University, Shanghai 200444, ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, ChinaInstitute of Health and Biomedical Innovation, Queensland University of Technology, 7 Brisbane 4059, AustraliaIntegrated Manufacturing Technologies Research and Application Center, Sabanci University, Tuzla 34956 Istanbul, Turkey; SUNUM Nanotechnology Research Center, Sabanci University, Tuzla 34956 Istanbul, Turkey; Faculty of Engineering and Natural Sciences, Sabanci University, Tuzla 34956 Istanbul, TurkeyState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, ChinaMelanoma is a serious malignant skin tumor. Effectively eliminating melanoma and healing after-surgical wounds are always challenges in clinical studies. To address these problems, we propose manganese-doped calcium silicate nanowire-incorporated alginate hydrogels (named MCSA hydrogels) for in situ photothermal ablation of melanoma followed by the wound healing process. The proposed MCSA hydrogel had controllable gelation properties, reasonable strength, and excellent bioactivity due to the incorporated calcium silicate nanowires as the in situ cross-linking agents and bioactive components. The doping of manganese into calcium silicate nanowires gave them excellent photothermal effects for eradicating melanoma effectively under near infrared (NIR) irradiation. Moreover, the synergistic effect of manganese and silicon in the MCSA hydrogel effectively promotes migration and proliferation of vascular endothelial cells and promotes angiogenesis. Hence, such bifunctional bioactive hydrogels could achieve combined functions of photothermal therapy and wound healing, showing great promise for melanoma therapy and tissue regeneration.http://dx.doi.org/10.34133/2021/9780943 |
| spellingShingle | Zhongcao Wu Hui Zhuang Bing Ma Yin Xiao Bahattin Koc Yufang Zhu Chengtie Wu Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and Wound Healing Research |
| title | Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and Wound Healing |
| title_full | Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and Wound Healing |
| title_fullStr | Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and Wound Healing |
| title_full_unstemmed | Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and Wound Healing |
| title_short | Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and Wound Healing |
| title_sort | manganese doped calcium silicate nanowire composite hydrogels for melanoma treatment and wound healing |
| url | http://dx.doi.org/10.34133/2021/9780943 |
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