High-Risk Sarcoidosis: A Focus on Pulmonary, Cardiac, Hepatic and Renal Advanced Diseases, as Well as on Calcium Metabolism Abnormalities
Although sarcoidosis is generally regarded as a benign condition, approximately 20–30% of patients will develop a chronic and progressive disease. Advanced pulmonary fibrotic sarcoidosis and cardiac involvement are the main contributors to sarcoidosis morbidity and mortality, with failure of the liv...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/14/4/395 |
| _version_ | 1797298508024250368 |
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| author | Dominique Israël-Biet Nicol Bernardinello Jean Pastré Claudio Tana Paolo Spagnolo |
| author_facet | Dominique Israël-Biet Nicol Bernardinello Jean Pastré Claudio Tana Paolo Spagnolo |
| author_sort | Dominique Israël-Biet |
| collection | DOAJ |
| description | Although sarcoidosis is generally regarded as a benign condition, approximately 20–30% of patients will develop a chronic and progressive disease. Advanced pulmonary fibrotic sarcoidosis and cardiac involvement are the main contributors to sarcoidosis morbidity and mortality, with failure of the liver and/or kidneys representing additional life-threatening situations. In this review, we discuss diagnosis and treatment of each of these complications and highlight how the integration of clinical, pathological and radiological features may help predict the development of such high-risk situations in sarcoid patients. |
| first_indexed | 2024-03-07T22:35:52Z |
| format | Article |
| id | doaj.art-bcbafb4f2d3e481c829929acdb6b4db7 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-07T22:35:52Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-bcbafb4f2d3e481c829929acdb6b4db72024-02-23T15:13:47ZengMDPI AGDiagnostics2075-44182024-02-0114439510.3390/diagnostics14040395High-Risk Sarcoidosis: A Focus on Pulmonary, Cardiac, Hepatic and Renal Advanced Diseases, as Well as on Calcium Metabolism AbnormalitiesDominique Israël-Biet0Nicol Bernardinello1Jean Pastré2Claudio Tana3Paolo Spagnolo4Service de Pneumologie et Soins Intensifs, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, 75015 Paris, FranceDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, ItalyService de Pneumologie et Soins Intensifs, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, 75015 Paris, FranceGeriatrics Clinic, SS Annunziata University-Hospital of Chieti, 66100 Chieti, ItalySection of Respiratory Diseases, University of Padova, 35121 Padova, ItalyAlthough sarcoidosis is generally regarded as a benign condition, approximately 20–30% of patients will develop a chronic and progressive disease. Advanced pulmonary fibrotic sarcoidosis and cardiac involvement are the main contributors to sarcoidosis morbidity and mortality, with failure of the liver and/or kidneys representing additional life-threatening situations. In this review, we discuss diagnosis and treatment of each of these complications and highlight how the integration of clinical, pathological and radiological features may help predict the development of such high-risk situations in sarcoid patients.https://www.mdpi.com/2075-4418/14/4/395sarcoidosishigh-risk sarcoidosissarcoidosis mortalitysarcoidosis morbidity |
| spellingShingle | Dominique Israël-Biet Nicol Bernardinello Jean Pastré Claudio Tana Paolo Spagnolo High-Risk Sarcoidosis: A Focus on Pulmonary, Cardiac, Hepatic and Renal Advanced Diseases, as Well as on Calcium Metabolism Abnormalities Diagnostics sarcoidosis high-risk sarcoidosis sarcoidosis mortality sarcoidosis morbidity |
| title | High-Risk Sarcoidosis: A Focus on Pulmonary, Cardiac, Hepatic and Renal Advanced Diseases, as Well as on Calcium Metabolism Abnormalities |
| title_full | High-Risk Sarcoidosis: A Focus on Pulmonary, Cardiac, Hepatic and Renal Advanced Diseases, as Well as on Calcium Metabolism Abnormalities |
| title_fullStr | High-Risk Sarcoidosis: A Focus on Pulmonary, Cardiac, Hepatic and Renal Advanced Diseases, as Well as on Calcium Metabolism Abnormalities |
| title_full_unstemmed | High-Risk Sarcoidosis: A Focus on Pulmonary, Cardiac, Hepatic and Renal Advanced Diseases, as Well as on Calcium Metabolism Abnormalities |
| title_short | High-Risk Sarcoidosis: A Focus on Pulmonary, Cardiac, Hepatic and Renal Advanced Diseases, as Well as on Calcium Metabolism Abnormalities |
| title_sort | high risk sarcoidosis a focus on pulmonary cardiac hepatic and renal advanced diseases as well as on calcium metabolism abnormalities |
| topic | sarcoidosis high-risk sarcoidosis sarcoidosis mortality sarcoidosis morbidity |
| url | https://www.mdpi.com/2075-4418/14/4/395 |
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