Myeloid and CD4 T Cells Comprise the Latent Reservoir in Antiretroviral Therapy-Suppressed SIVmac251-Infected Macaques

Myeloid and CD4 T Cells Comprise the Latent Reservoir in Antiretroviral Therapy-Suppressed SIVmac251-Infected Macaques

ABSTRACT Human immunodeficiency virus (HIV) eradication or long-term suppression in the absence of antiretroviral therapy (ART) requires an understanding of all viral reservoirs that could contribute to viral rebound after ART interruption. CD4 T cells (CD4s) are recognized as the predominant reserv...

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Bibliographic Details
Main Authors: Celina M. Abreu, Rebecca T. Veenhuis, Claudia R. Avalos, Shelby Graham, Daymond R. Parrilla, Edna A. Ferreira, Suzanne E. Queen, Erin N. Shirk, Brandon T. Bullock, Ming Li, Kelly A. Metcalf Pate, Sarah E. Beck, Lisa M. Mangus, Joseph L. Mankowski, Feilim Mac Gabhann, Shelby L. O’Connor, Lucio Gama, Janice E. Clements
Format: Article
Language:English
Published: American Society for Microbiology 2019-08-01
Series:mBio
Subjects:
HIV
latency
SIV
macrophages
monocytes
Online Access:https://journals.asm.org/doi/10.1128/mBio.01659-19

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