Mitochondrial dysfunction underlies impaired neurovascular coupling following traumatic brain injury

Mitochondrial dysfunction underlies impaired neurovascular coupling following traumatic brain injury

Traumatic brain injury (TBI) involves an acute injury (primary damage), which may evolve in the hours to days after impact (secondary damage). Seizures and cortical spreading depolarization (CSD) are metabolically demanding processes that may worsen secondary brain injury. Metabolic stress has been...

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Bibliographic Details
Main Authors: Gerben van Hameren, Jamil Muradov, Anna Minarik, Refat Aboghazleh, Sophie Orr, Shayna Cort, Keiran Andrews, Caitlin McKenna, Nga Thy Pham, Mark A. MacLean, Alon Friedman
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Neurobiology of Disease
Subjects:
Traumatic brain injury
Cortical spreading depolarization
Neurovascular coupling
Mitochondria
Reactive oxygen species
Seizures
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612300284X

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