Discovery of pulmonary fibrosis inhibitor targeting TGF-β RI in Polygonum cuspidatum by high resolution mass spectrometry with in silico strategy

Discovery of pulmonary fibrosis inhibitor targeting TGF-β RI in Polygonum cuspidatum by high resolution mass spectrometry with in silico strategy

Pulmonary fibrosis (PF) is an irreversible lung disease that is characterized by excessive scar tissue with a poor median survival rate of 2–3 years. The inhibition of transforming growth factor-β receptor type-I (TGF-β RI) by an appropriate drug may provide a promising strategy for the treatment of...

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Bibliographic Details
Main Authors: Huarong Xu, Jiameng Qu, Jian Wang, Kefei Han, Qing Li, Wenchuan Bi, Ran Liu
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Polygonum cuspidatum
Pulmonary fibrosis
TGF-β receptor type-I
Resveratrol
High resolution mass spectrometry
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177919308998

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