Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala
Oxidative stress, caused by the overproduction of free radicals, leads to the development of many chronic diseases including cancer. Free radicals are known to damage cellular biomolecules like lipids, proteins, and DNA that results in activation of multiple signaling pathways, growth factors, trans...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/9/1/72 |
| _version_ | 1797715057399824384 |
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| author | Sahdeo Prasad Sanjay K. Srivastava |
| author_facet | Sahdeo Prasad Sanjay K. Srivastava |
| author_sort | Sahdeo Prasad |
| collection | DOAJ |
| description | Oxidative stress, caused by the overproduction of free radicals, leads to the development of many chronic diseases including cancer. Free radicals are known to damage cellular biomolecules like lipids, proteins, and DNA that results in activation of multiple signaling pathways, growth factors, transcription factors, kinases, inflammatory and cell cycle regulatory molecules. Antioxidants, which are classified as exogenous and endogenous, are responsible for the removal of free radicals and consequently the reduction in oxidative stress-mediated diseases. Diet and medicinal herbs are the major source of antioxidants. Triphala, which is a traditional Ayurvedic formulation that has been used for centuries, has been shown to have immense potential to boost antioxidant activity. It scavenges free radicals, restores antioxidant enzymes and non-enzyme levels, and decreases lipid peroxidation. In addition, Triphala is revered as a chemopreventive, chemotherapeutic, immunomodulatory, and radioprotective agent. Accumulated evidence has revealed that Triphala modulates multiple cell signaling pathways including, ERK, MAPK, NF-κB, Akt, c-Myc, VEGFR, mTOR, tubulin, p53, cyclin D1, anti-apoptotic and pro-apoptotic proteins. The present review focuses on the comprehensive appraisal of Triphala in oxidative stress and cancer. |
| first_indexed | 2024-03-12T08:02:16Z |
| format | Article |
| id | doaj.art-bcbe86764fd140c4a603c3260e45988b |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T08:02:16Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-bcbe86764fd140c4a603c3260e45988b2023-09-02T19:50:48ZengMDPI AGAntioxidants2076-39212020-01-01917210.3390/antiox9010072antiox9010072Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of TriphalaSahdeo Prasad0Sanjay K. Srivastava1Department of Immunotherapeutics and Biotechnology, and Center for Tumor Immunology and Targeted Cancer Therapy, Texas Tech University Health Sciences Center, Abilene, TX 79601, USADepartment of Immunotherapeutics and Biotechnology, and Center for Tumor Immunology and Targeted Cancer Therapy, Texas Tech University Health Sciences Center, Abilene, TX 79601, USAOxidative stress, caused by the overproduction of free radicals, leads to the development of many chronic diseases including cancer. Free radicals are known to damage cellular biomolecules like lipids, proteins, and DNA that results in activation of multiple signaling pathways, growth factors, transcription factors, kinases, inflammatory and cell cycle regulatory molecules. Antioxidants, which are classified as exogenous and endogenous, are responsible for the removal of free radicals and consequently the reduction in oxidative stress-mediated diseases. Diet and medicinal herbs are the major source of antioxidants. Triphala, which is a traditional Ayurvedic formulation that has been used for centuries, has been shown to have immense potential to boost antioxidant activity. It scavenges free radicals, restores antioxidant enzymes and non-enzyme levels, and decreases lipid peroxidation. In addition, Triphala is revered as a chemopreventive, chemotherapeutic, immunomodulatory, and radioprotective agent. Accumulated evidence has revealed that Triphala modulates multiple cell signaling pathways including, ERK, MAPK, NF-κB, Akt, c-Myc, VEGFR, mTOR, tubulin, p53, cyclin D1, anti-apoptotic and pro-apoptotic proteins. The present review focuses on the comprehensive appraisal of Triphala in oxidative stress and cancer.https://www.mdpi.com/2076-3921/9/1/72oxidative stresscancerantioxidanttriphalaayurvedachemoprevention and chemotherapy |
| spellingShingle | Sahdeo Prasad Sanjay K. Srivastava Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala Antioxidants oxidative stress cancer antioxidant triphala ayurveda chemoprevention and chemotherapy |
| title | Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala |
| title_full | Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala |
| title_fullStr | Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala |
| title_full_unstemmed | Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala |
| title_short | Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala |
| title_sort | oxidative stress and cancer chemopreventive and therapeutic role of triphala |
| topic | oxidative stress cancer antioxidant triphala ayurveda chemoprevention and chemotherapy |
| url | https://www.mdpi.com/2076-3921/9/1/72 |
| work_keys_str_mv | AT sahdeoprasad oxidativestressandcancerchemopreventiveandtherapeuticroleoftriphala AT sanjayksrivastava oxidativestressandcancerchemopreventiveandtherapeuticroleoftriphala |