Molecular Spectroscopic Markers of DNA Damage
Every cell in a living organism is constantly exposed to physical and chemical factors which damage the molecular structure of proteins, lipids, and nucleic acids. Cellular DNA lesions are the most dangerous because the genetic information, critical for the identity and function of each eukaryotic c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/3/561 |
| _version_ | 1828430192829267968 |
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| author | Kamila Sofińska Natalia Wilkosz Marek Szymoński Ewelina Lipiec |
| author_facet | Kamila Sofińska Natalia Wilkosz Marek Szymoński Ewelina Lipiec |
| author_sort | Kamila Sofińska |
| collection | DOAJ |
| description | Every cell in a living organism is constantly exposed to physical and chemical factors which damage the molecular structure of proteins, lipids, and nucleic acids. Cellular DNA lesions are the most dangerous because the genetic information, critical for the identity and function of each eukaryotic cell, is stored in the DNA. In this review, we describe spectroscopic markers of DNA damage, which can be detected by infrared, Raman, surface-enhanced Raman, and tip-enhanced Raman spectroscopies, using data acquired from DNA solutions and mammalian cells. Various physical and chemical DNA damaging factors are taken into consideration, including ionizing and non-ionizing radiation, chemicals, and chemotherapeutic compounds. All major spectral markers of DNA damage are presented in several tables, to give the reader a possibility of fast identification of the spectral signature related to a particular type of DNA damage. |
| first_indexed | 2024-12-10T17:45:00Z |
| format | Article |
| id | doaj.art-bcbec54189d24b0daf19512dec9340f1 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T17:45:00Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-bcbec54189d24b0daf19512dec9340f12022-12-22T01:39:16ZengMDPI AGMolecules1420-30492020-01-0125356110.3390/molecules25030561molecules25030561Molecular Spectroscopic Markers of DNA DamageKamila Sofińska0Natalia Wilkosz1Marek Szymoński2Ewelina Lipiec3M. Smoluchowski Institute of Physics, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, PolandM. Smoluchowski Institute of Physics, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, PolandM. Smoluchowski Institute of Physics, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, PolandM. Smoluchowski Institute of Physics, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, PolandEvery cell in a living organism is constantly exposed to physical and chemical factors which damage the molecular structure of proteins, lipids, and nucleic acids. Cellular DNA lesions are the most dangerous because the genetic information, critical for the identity and function of each eukaryotic cell, is stored in the DNA. In this review, we describe spectroscopic markers of DNA damage, which can be detected by infrared, Raman, surface-enhanced Raman, and tip-enhanced Raman spectroscopies, using data acquired from DNA solutions and mammalian cells. Various physical and chemical DNA damaging factors are taken into consideration, including ionizing and non-ionizing radiation, chemicals, and chemotherapeutic compounds. All major spectral markers of DNA damage are presented in several tables, to give the reader a possibility of fast identification of the spectral signature related to a particular type of DNA damage.https://www.mdpi.com/1420-3049/25/3/561dna damagedouble strand breaksdsbsingle strand breaksssbdna lesionsdna damage spectroscopic markers |
| spellingShingle | Kamila Sofińska Natalia Wilkosz Marek Szymoński Ewelina Lipiec Molecular Spectroscopic Markers of DNA Damage Molecules dna damage double strand breaks dsb single strand breaks ssb dna lesions dna damage spectroscopic markers |
| title | Molecular Spectroscopic Markers of DNA Damage |
| title_full | Molecular Spectroscopic Markers of DNA Damage |
| title_fullStr | Molecular Spectroscopic Markers of DNA Damage |
| title_full_unstemmed | Molecular Spectroscopic Markers of DNA Damage |
| title_short | Molecular Spectroscopic Markers of DNA Damage |
| title_sort | molecular spectroscopic markers of dna damage |
| topic | dna damage double strand breaks dsb single strand breaks ssb dna lesions dna damage spectroscopic markers |
| url | https://www.mdpi.com/1420-3049/25/3/561 |
| work_keys_str_mv | AT kamilasofinska molecularspectroscopicmarkersofdnadamage AT nataliawilkosz molecularspectroscopicmarkersofdnadamage AT marekszymonski molecularspectroscopicmarkersofdnadamage AT ewelinalipiec molecularspectroscopicmarkersofdnadamage |