Synthesis, Screening and Characterization of Novel Potent Arp2/3 Inhibitory Compounds Analogous to CK-666

Synthesis, Screening and Characterization of Novel Potent Arp2/3 Inhibitory Compounds Analogous to CK-666

Branched actin networks polymerized by the Actin-related protein 2 and 3 (Arp2/3) complex play key roles in force generation and membrane remodeling. These networks are particularly important for cell migration, where they drive membrane protrusions of lamellipodia. Several Arp2/3 inhibitory compoun...

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Bibliographic Details
Main Authors: Artem I. Fokin, Roman N. Chuprov-Netochin, Alexander S. Malyshev, Stéphane Romero, Marina N. Semenova, Leonid D. Konyushkin, Sergey V. Leonov, Victor V. Semenov, Alexis M. Gautreau
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
Arp2/3
branched actin
Arp2/3 inhibitors
CK-666
actin polymerization
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.896994/full

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