Nipple Sparing Mastectomy as a Risk-Reducing Procedure for <i>BRCA</i>-Mutated Patients
Growing numbers of asymptomatic women who become aware of carrying a breast cancer gene mutation (<i>BRCA</i>) mutation are choosing to undergo risk-reducing bilateral mastectomies with immediate breast reconstruction. We reviewed the literature with the aim of assessing the oncological...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/2/253 |
| _version_ | 1797411921473830912 |
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| author | Nicola Rocco Giacomo Montagna Carmen Criscitiello Maurizio Bruno Nava Francesca Privitera Wafa Taher Antonio Gloria Giuseppe Catanuto |
| author_facet | Nicola Rocco Giacomo Montagna Carmen Criscitiello Maurizio Bruno Nava Francesca Privitera Wafa Taher Antonio Gloria Giuseppe Catanuto |
| author_sort | Nicola Rocco |
| collection | DOAJ |
| description | Growing numbers of asymptomatic women who become aware of carrying a breast cancer gene mutation (<i>BRCA</i>) mutation are choosing to undergo risk-reducing bilateral mastectomies with immediate breast reconstruction. We reviewed the literature with the aim of assessing the oncological safety of nipple-sparing mastectomy (NSM) as a risk-reduction procedure in <i>BRCA</i>-mutated patients. Nine studies reporting on the incidence of primary breast cancer post NSM in asymptomatic <i>BRCA</i> mutated patients undergoing risk-reducing bilateral procedures met the inclusion criteria. NSM appears to be a safe option for <i>BRCA</i> mutation carriers from an oncological point of view, with low reported rates of new breast cancers, low rates of postoperative complications, and high levels of satisfaction and postoperative quality of life. However, larger multi-institutional studies with longer follow-up are needed to establish this procedure as the best surgical option in this setting. |
| first_indexed | 2024-03-09T04:53:21Z |
| format | Article |
| id | doaj.art-bcc254a58cf441aaa8d486c1e9cff831 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T04:53:21Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-bcc254a58cf441aaa8d486c1e9cff8312023-12-03T13:08:40ZengMDPI AGGenes2073-44252021-02-0112225310.3390/genes12020253Nipple Sparing Mastectomy as a Risk-Reducing Procedure for <i>BRCA</i>-Mutated PatientsNicola Rocco0Giacomo Montagna1Carmen Criscitiello2Maurizio Bruno Nava3Francesca Privitera4Wafa Taher5Antonio Gloria6Giuseppe Catanuto7G.RE.T.A. Group for Reconstructive and Therapeutic Advancements, 80100 Naples, ItalyBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10001, USADepartment of Oncology and Haematology (DIPO), University of Milan, 20122 Milan, ItalyG.RE.T.A. Group for Reconstructive and Therapeutic Advancements, 20122 Milan, ItalyMultidisciplinary Breast Unit, Azienda Ospedaliera Cannizzaro, 95021 Catania, ItalySurrey and Sussex Health Care, NHS Trust, London W1W 5EF, UKInstitute of Polymers, Composites and Biomaterials—National Research Council of Italy, 80125 Naples, ItalyMultidisciplinary Breast Unit, Azienda Ospedaliera Cannizzaro, 95021 Catania, ItalyGrowing numbers of asymptomatic women who become aware of carrying a breast cancer gene mutation (<i>BRCA</i>) mutation are choosing to undergo risk-reducing bilateral mastectomies with immediate breast reconstruction. We reviewed the literature with the aim of assessing the oncological safety of nipple-sparing mastectomy (NSM) as a risk-reduction procedure in <i>BRCA</i>-mutated patients. Nine studies reporting on the incidence of primary breast cancer post NSM in asymptomatic <i>BRCA</i> mutated patients undergoing risk-reducing bilateral procedures met the inclusion criteria. NSM appears to be a safe option for <i>BRCA</i> mutation carriers from an oncological point of view, with low reported rates of new breast cancers, low rates of postoperative complications, and high levels of satisfaction and postoperative quality of life. However, larger multi-institutional studies with longer follow-up are needed to establish this procedure as the best surgical option in this setting.https://www.mdpi.com/2073-4425/12/2/253breast cancer<i>BRCA</i> mutationsrisk reductionnipple-sparing mastectomies |
| spellingShingle | Nicola Rocco Giacomo Montagna Carmen Criscitiello Maurizio Bruno Nava Francesca Privitera Wafa Taher Antonio Gloria Giuseppe Catanuto Nipple Sparing Mastectomy as a Risk-Reducing Procedure for <i>BRCA</i>-Mutated Patients Genes breast cancer <i>BRCA</i> mutations risk reduction nipple-sparing mastectomies |
| title | Nipple Sparing Mastectomy as a Risk-Reducing Procedure for <i>BRCA</i>-Mutated Patients |
| title_full | Nipple Sparing Mastectomy as a Risk-Reducing Procedure for <i>BRCA</i>-Mutated Patients |
| title_fullStr | Nipple Sparing Mastectomy as a Risk-Reducing Procedure for <i>BRCA</i>-Mutated Patients |
| title_full_unstemmed | Nipple Sparing Mastectomy as a Risk-Reducing Procedure for <i>BRCA</i>-Mutated Patients |
| title_short | Nipple Sparing Mastectomy as a Risk-Reducing Procedure for <i>BRCA</i>-Mutated Patients |
| title_sort | nipple sparing mastectomy as a risk reducing procedure for i brca i mutated patients |
| topic | breast cancer <i>BRCA</i> mutations risk reduction nipple-sparing mastectomies |
| url | https://www.mdpi.com/2073-4425/12/2/253 |
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