Structural and Biological Basis of Alphacoronavirus nsp1 Associated with Host Proliferation and Immune Evasion

Structural and Biological Basis of Alphacoronavirus nsp1 Associated with Host Proliferation and Immune Evasion

Non-structural protein 1 (nsp1) is only characterized in alphacoronaviruses (α-CoVs) and betacoronaviruses (β-CoVs). There have been extensive researches on how the β-CoVs nsp1 regulates viral virulence by inhibiting host protein synthesis, but the regulatory mechanism of the α-CoVs nsp1 is still un...

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Bibliographic Details
Main Authors: Zhou Shen, Yiling Yang, Siqi Yang, Guangxu Zhang, Shaobo Xiao, Zhen F. Fu, Guiqing Peng
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Viruses
Subjects:
alphacoronavirus nsp1
crystal structure
structure-function
infectious disease
cellular immune response
RNA sequence
Online Access:https://www.mdpi.com/1999-4915/12/8/812

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