Small but strong: the emerging role of small nucleolar RNA in cardiovascular diseases
Cardiovascular diseases (CVDs) are the leading cause of mortality and disability worldwide. Numerous studies have demonstrated that non-coding RNAs (ncRNAs) play a primary role in CVD development. Therefore, studies on the mechanisms of ncRNAs are essential for further efforts to prevent and treat C...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1292925/full |
| _version_ | 1797628112435937280 |
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| author | Xue Sun Xue Sun Gebang Wang Wenting Luo Hui Gu Wei Ma Xiaowei Wei Dan Liu Shanshan Jia Songying Cao Yu Wang Zhengwei Yuan |
| author_facet | Xue Sun Xue Sun Gebang Wang Wenting Luo Hui Gu Wei Ma Xiaowei Wei Dan Liu Shanshan Jia Songying Cao Yu Wang Zhengwei Yuan |
| author_sort | Xue Sun |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) are the leading cause of mortality and disability worldwide. Numerous studies have demonstrated that non-coding RNAs (ncRNAs) play a primary role in CVD development. Therefore, studies on the mechanisms of ncRNAs are essential for further efforts to prevent and treat CVDs. Small nucleolar RNAs (snoRNAs) are a novel species of non-conventional ncRNAs that guide post-transcriptional modifications and the subsequent maturation of small nuclear RNA and ribosomal RNA. Evidently, snoRNAs are extensively expressed in human tissues and may regulate different illnesses. Particularly, as the next-generation sequencing techniques have progressed, snoRNAs have been shown to be differentially expressed in CVDs, suggesting that they may play a role in the occurrence and progression of cardiac illnesses. However, the molecular processes and signaling pathways underlying the function of snoRNAs remain unidentified. Therefore, it is of great value to comprehensively investigate the association between snoRNAs and CVDs. The aim of this review was to collate existing literature on the biogenesis, characteristics, and potential regulatory mechanisms of snoRNAs. In particular, we present a scientific update on these snoRNAs and their relevance to CVDs in an effort to cast new light on the functions of snoRNAs in the clinical diagnosis of CVDs. |
| first_indexed | 2024-03-11T10:34:55Z |
| format | Article |
| id | doaj.art-bcc45d22f5b44a009aecff5d65e93069 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-11T10:34:55Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-bcc45d22f5b44a009aecff5d65e930692023-11-14T11:27:51ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-11-011110.3389/fcell.2023.12929251292925Small but strong: the emerging role of small nucleolar RNA in cardiovascular diseasesXue Sun0Xue Sun1Gebang Wang2Wenting Luo3Hui Gu4Wei Ma5Xiaowei Wei6Dan Liu7Shanshan Jia8Songying Cao9Yu Wang10Zhengwei Yuan11Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaKey Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Thoracic Surgery, Liaoning Cancer Hospital and Institute, Cancer Hospital of Dalian University of Technology, Shenyang, Liaoning, ChinaKey Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaKey Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaKey Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaKey Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaKey Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaKey Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaKey Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaKey Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaCardiovascular diseases (CVDs) are the leading cause of mortality and disability worldwide. Numerous studies have demonstrated that non-coding RNAs (ncRNAs) play a primary role in CVD development. Therefore, studies on the mechanisms of ncRNAs are essential for further efforts to prevent and treat CVDs. Small nucleolar RNAs (snoRNAs) are a novel species of non-conventional ncRNAs that guide post-transcriptional modifications and the subsequent maturation of small nuclear RNA and ribosomal RNA. Evidently, snoRNAs are extensively expressed in human tissues and may regulate different illnesses. Particularly, as the next-generation sequencing techniques have progressed, snoRNAs have been shown to be differentially expressed in CVDs, suggesting that they may play a role in the occurrence and progression of cardiac illnesses. However, the molecular processes and signaling pathways underlying the function of snoRNAs remain unidentified. Therefore, it is of great value to comprehensively investigate the association between snoRNAs and CVDs. The aim of this review was to collate existing literature on the biogenesis, characteristics, and potential regulatory mechanisms of snoRNAs. In particular, we present a scientific update on these snoRNAs and their relevance to CVDs in an effort to cast new light on the functions of snoRNAs in the clinical diagnosis of CVDs.https://www.frontiersin.org/articles/10.3389/fcell.2023.1292925/fullbiomarkercardiovascular diseaseheartncRNAsSnoRNA |
| spellingShingle | Xue Sun Xue Sun Gebang Wang Wenting Luo Hui Gu Wei Ma Xiaowei Wei Dan Liu Shanshan Jia Songying Cao Yu Wang Zhengwei Yuan Small but strong: the emerging role of small nucleolar RNA in cardiovascular diseases Frontiers in Cell and Developmental Biology biomarker cardiovascular disease heart ncRNAs SnoRNA |
| title | Small but strong: the emerging role of small nucleolar RNA in cardiovascular diseases |
| title_full | Small but strong: the emerging role of small nucleolar RNA in cardiovascular diseases |
| title_fullStr | Small but strong: the emerging role of small nucleolar RNA in cardiovascular diseases |
| title_full_unstemmed | Small but strong: the emerging role of small nucleolar RNA in cardiovascular diseases |
| title_short | Small but strong: the emerging role of small nucleolar RNA in cardiovascular diseases |
| title_sort | small but strong the emerging role of small nucleolar rna in cardiovascular diseases |
| topic | biomarker cardiovascular disease heart ncRNAs SnoRNA |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1292925/full |
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